Supplementierung von Vitamin C und D bei kritisch Kranken

Hill, Aileen; Starchl, Christina; Dresen, Ellen; Stoppe, Christian; Amrein, Karin

doi:10.1007/s00063-022-00986-6

Cited by 3 publications

(4 citation statements)

References 32 publications

(50 reference statements)

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“…As Hill et al pointed out in their study, vita D plays a controlling role in the ACE/angiotensin (Ang) II/angiotensin type I receptor axis and the ACE2/ Ang axis activity, which is used by SARS-CoV-2 to attack host cells. 78 This increases the concentration and expression of ACE2 and Ang. A key anti-inflammatory and antioxidant role is played by ACE2/Ang that protects the lung against ARDS.…”

Section: Resultsmentioning

confidence: 99%

The association between vitamin D intake with inflammatory and biochemical indices and mortality in critically ill patients with COVID‐19: A case‐control study

Rabbani

Ahmadzadeh

Hajipour

et al. 2023

Immunity Inflam & Disease

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Background The coronavirus disease‐2019 (COVID‐19) has become a worldwide health issue with widespread hospitalization and dependence on the intensive care unit (ICU). Vitamin D has a key role in modulating immune cells and modulating the inflammatory responses. This study aimed to investigate the association of vitamin D supplementation with inflammatory, biochemical, and mortality indices in critically ill patients with COVID‐19. Methods This case‐control study was conducted on critically ill COVID‐19 patients hospitalized in the ICU including the survived >30 day patients as the case group and dead patients as the control group. The status of vitamin D supplementation and inflammatory and biochemical indices of the patients were retrieved from the medical records. Logistic regression method was used to assess the association between 30 days survival and vitamin D supplement intake. Results Compared to the group of COVID‐19 patients who died in <30 day, the survived patients had a lower eosinophile level (2.2 ± 0.5 vs. 6 ± 0.0, p < .001) and higher vitamin D supplementation duration (9 ± 4.4 vs. 3.3 ± 1.9 day, p = .001). Vitamin D supplementation had a positive association with survival in COVID‐19 patients (OR: 1.98, 95% CI: 1.15−3.40, p < .05). The association remained significant after adjustments fot age, sex, underlying diseases, and smoking. Conclusion Vitamin D supplementation in critically ill patients with COVID‐19 has the potential to increase survivability within the first 30 days of hospitalization.

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Section: Resultsmentioning

confidence: 99%

The association between vitamin D intake with inflammatory and biochemical indices and mortality in critically ill patients with COVID‐19: A case‐control study

Rabbani

Ahmadzadeh

Hajipour

et al. 2023

Immunity Inflam & Disease

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“…However, adverse effects include diarrhea and the increased formation of kidney stones. The recommended minimum intake of VitC varies from 50 mg/day in infants to 110 mg/day in adolescents [ 90 , 91 ].…”

Section: Micronutrientsmentioning

confidence: 99%

Recommendations for Nutritional Supplementation in Pediatric Oncology: A Compilation of the Facts

et al. 2023

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Background: As one of the few modifiable risk factors, the importance of dietary patterns for both disease prevention and treatment outcome in pediatric oncology has gained increasing popularity. Malnutrition is associated with lower survival rates, tolerance to treatment, and quality of life. Yet, especially in children with malignancies, nutritional deterioration is common, and pediatric cancer patients often present with inadequate intake of micro- and macronutrients alike. Despite the reported widespread use of dietary supplements, few empirical data provide a basis for clinical recommendations, and evidence for their efficacy is inconsistent. Current literature lacks a systematic approach as to how and which supplements should be recommended for specific patients, types of cancer, or during specific treatments. The aim of this review is to highlight the role of the most frequently used nutrients in pediatric malignant diseases and to give a practical guide based on current scientific evidence. Methods: A comprehensive literature search was conducted on PubMed through April 2023 to select meta-analyses, systematic reviews, observational studies, and individual randomized controlled trials (RCTs) of macro- and micronutrient supplementation in pediatric oncology. The search strategy included the following medical subject headings (MeSH) and keywords: “childhood cancer”, “pediatric oncology”, “nutritional status”, “dietary supplements”, “vitamins”, “micronutrients”, “calcium”, “magnesium”, “vitamin D”, “zinc” “glutamine”, “selen”, and “omega-3 fatty acids”. The reference lists of all relevant articles were screened to include potentially pertinent studies. Results: The present review provides a comprehensive and updated overview of the latest evidence about the role of nutrition and diet in pediatric oncology, also focusing on different nutritional interventions available for the management of the disease. We summarize evidence about the importance of adequate nutrition in childhood cancer and the role of several micronutrients and critically interpret the findings. Possible effects and benefits of supplementation during chemotherapy are discussed, as are strategies for primary and secondary prevention. Conclusions: We here describe the obvious benefits of dietary supplementation for childhood cancer. Further large-scale clinical trials are required to verify the impacts of deficiencies and the possible benefits of supplementation and optimal dosages. (337 words).

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“…Adequate intake of micronutrients, independent of parenteral or enteral nutrition intake of macronutrients -proteins, lipids, and carbohydrates -is the basis of a sufficient diet during critical illness. These micronutrients, including minerals (calcium, phosphorus, magnesium, selenium) and vitamins (D, C, K) play an important role during the acute setting of severe disease [9], and deficiency is associated with poor outcomes in critical illness [10 & ]. The purpose of this narrative review is to 1) summarize previous literature on metabolism of different micronutrients in critically ill patients with potential effect on bone metabolism and 2) review current evidence of the benefits and harms of supplementation of micronutrients aiming to protect against osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

“…Adequate intake of micronutrients, independent of parenteral or enteral nutrition intake of macronutrients - proteins, lipids, and carbohydrates – is the basis of a sufficient diet during critical illness. These micronutrients, including minerals (calcium, phosphorus, magnesium, selenium) and vitamins (D, C, K) play an important role during the acute setting of severe disease [9], and deficiency is associated with poor outcomes in critical illness [10 ▪ ].…”

Section: Introductionmentioning

confidence: 99%

Micronutrient intake to protect against osteoporosis during and after critical illness

Nair,

Orford,

Kerschan-Schindl

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of review Improved survival from critical illness has enhanced the focus on ways to augment functional outcomes following discharge from the Intensive Care Unit. An area that is gaining increased attention is the effect of critical illness on bone health and fragility fractures following the episode. This review discusses the micronutrients that may play a role in bone metabolism and the potential benefits of their supplementation to prevent osteoporosis. These include calcium, phosphorous, magnesium, vitamin D, vitamin C, vitamin K, and certain trace elements. Findings Although there is sound physiological basis for the involvement of these micronutrients in bone health and fracture prevention, there are few clinically relevant publications in this area with calcium and vitamin D being the best studied to date. Summary In the absence of high-quality evidence in critically ill populations, attention to measurement and supplementation of these micronutrients as per current guidelines outlining micronutrient requirements in enteral and parenteral nutrition might mitigate bone loss and its sequelae in the recovery phase from critical illness.

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Supplementierung von Vitamin C und D bei kritisch Kranken

Cited by 3 publications

References 32 publications

The association between vitamin D intake with inflammatory and biochemical indices and mortality in critically ill patients with COVID‐19: A case‐control study

The association between vitamin D intake with inflammatory and biochemical indices and mortality in critically ill patients with COVID‐19: A case‐control study

Recommendations for Nutritional Supplementation in Pediatric Oncology: A Compilation of the Facts

Micronutrient intake to protect against osteoporosis during and after critical illness

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