Supplementation with vitamins C, E, β‐carotene and selenium has no effect on anti‐oxidant status and immune responses in allergic adults: a randomized controlled trial

Dunstan, Janet; Breckler, L.A.; Hale, J.; Lehmann, H.; Franklin, Peter; Lyons, Graham; Ching, Simon; Mori, Trevor A.; Barden, Anne; Prescott, Susan L.

doi:10.1111/j.1365-2222.2007.02657.x

Cited by 49 publications

(36 citation statements)

References 33 publications

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“…For example, one study reported significantly decreased consumption of corticosteroids after Se supplementation with 200 lg/day for 96 weeks in corticoid-dependent asthmatics (82). However, other studies failed to confirm any benefit from Se supplementation for 99 asthmatic adults using 100 lg/day Se as high-Se yeast or for 54 allergic adults using 76 lg/day Se as high-Se garlic (61,226). Based on these findings, Se supplementation has not generally been…”

Section: Intestinal Inflammation and Food-borne Illnessesmentioning

confidence: 72%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

680

496

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Dietary selenium (]Se), mainly through its incorporation into selenoproteins, plays an important role in inflammation and immunity. Adequate levels of Se are important for initiating immunity, but they are also involved in regulating excessive immune responses and chronic inflammation. Evidence has emerged regarding roles for individual selenoproteins in regulating inflammation and immunity, and this has provided important insight into mechanisms by which Se influences these processes. Se deficiency has long been recognized to negatively impact immune cells during activation, differentiation, and proliferation. This is related to increased oxidative stress, but additional functions such as protein folding and calcium flux may also be impaired in immune cells under Se deficient conditions. Supplementing diets with above-adequate levels of Se can also impinge on immune cell function, with some types of inflammation and immunity particularly affected and sexually dimorphic effects of Se levels in some cases. In this comprehensivearticle, the roles of Se and individual selenoproteins in regulating immune cell signaling and function are discussed. Particular emphasis is given to how Se and selenoproteins are linked to redox signaling, oxidative burst, calcium flux, and the subsequent effector functions of immune cells. Data obtained from cell culture and animal models are reviewed and compared with those involving human physiology and pathophysiology, including the effects of Se levels on inflammatory or immune-related diseases including anti-viral immunity, autoimmunity, sepsis, allergic asthma, and chronic inflammatory disorders. Finally, the benefits and potential adverse effects of intervention with Se supplementation for various inflammatory or immune disorders are discussed. Antioxid. Redox Signal. 16, 705-743.

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Section: Intestinal Inflammation and Food-borne Illnessesmentioning

confidence: 72%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

680

496

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“…Fruit may provide fibre and antioxidants, which may reduce oxidative stress-related inflammatory diseases (35). However, studies with antioxidant supplementation (3,36) have been disappointing calling for exploration of the interactions that may occur between nutrients and bioactive compounds.…”

Section: Discussionmentioning

confidence: 99%

Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control

Barros

Moreira

Fonseca

et al. 2008

Allergy

120

104

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Background: The traditional Mediterranean diet is claimed to possess antioxidant and immune‐regulatory properties in several chronic diseases. Typical Mediterranean foods have recently been associated with improvement of symptoms of asthma and rhinitis in children. However the effect of adherence to Mediterranean diet on adult asthma outcomes is unknown. We aimed to investigate the association between adherence to Mediterranean diet and asthma control.Methods: Cross sectional study of 174 asthmatics, mean (SD) age of 40 (15) years. The patients were defined as controlled, in contrast to noncontrolled, if they showed FEV1 ≥ 80% of predicted, exhaled nitric oxide (NO) ≤35 ppb, and Asthma Control Questionnaire score <1. Dietary intake was obtained by a food frequency questionnaire, and Mediterranean diet was assessed by alternate Mediterranean Diet (aMED) Score. Logistic regression models adjusting for confounders were performed to estimate the association between Mediterranean diet and asthma control.Results: Controlled asthmatics (23%) had significantly higher aMED Score, intake of fresh fruit, and lower intake of ethanol compared to noncontrolled (77%). High adherence to Mediterranean diet reduced 78% the risk of noncontrolled asthma after adjusting for gender, age, education, inhaled corticosteroids and energy intake (OR = 0.22; 95% CI = 0.05–0.85; P‐trend = 0.028). The higher intake of fresh fruit decreased the probability of having noncontrolled asthma (OR = 0.29; 95% CI = 0.10–0.83; P‐trend = 0.015), while the higher intake of ethanol had the opposite effect (OR = 3.16; 95% CI = 1.10–9.11; P‐trend = 0.035).Conclusion: High adherence to traditional Mediterranean diet increased the likelihood of asthma to be under control in adults. The study introduces a novel link between diet and asthma control, as measured by symptoms, lung function and exhaled NO.

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“…También influyen factores como la absorción y biodisponibilidad de cada individuo 23,24 . Algunos autores han investigado el efecto de la suplementación de mezclas de vitaminas y/o minerales, describiendo efectos favorables sobre los niveles de los marcadores de EO [25][26][27][28] . Por otra parte, los efectos de la suplementación de vitaminas y/o minerales sobre los marcadores de EO aún no son concluyentes y todavía no es posible definir la dosis y/o tiempo de suplementación con los que se logra mejores efectos antioxidantes 16 .…”

Section: Operacionalización De Las Variablesunclassified

Valoración nutricional como complemento de los estudios en población expuesta a agentes oxidantes

Galán

Erben

Simoniello

2013

Rev Esp Nutr Hum Diet

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Introducción: el estrés oxidativo (EO) se relaciona con un desequilibrio entre los sistemas oxidativos y antioxidantes, a favor de los primeros. El aporte de micronutrientes de origen dietario podría proveer de un efecto protector ante la exposición laboral a agentes oxidantes. El objetivo de este trabajo fue determinar si existe relación entre estado nutricional, hábitos higiénico-dietéticos, consumo de macro y micronutrientes y el EO en una población expuesta a agentes oxidantes, en comparación con una población no expuesta.Material y métodos: se estudiaron dos poblaciones de similares características, a excepción de la actividad laboral de una de ellas, constituidas por personas de ambos sexos, de 18 a 30 años de edad. El Grupo Expuesto estuvo constituido por 26 individuos que trabajaban en servicios de fotocopiado. El Grupo no Expuesto por 27 voluntarios que no realizan dicha actividad laboral. Se realizó una encuesta nutricional, dos recordatorios de 24 h, mediciones antropométricas y bioquímicas y determinación de marcadores de EO (Catalasa, relación GSH/GSSG y TBARS).Resultados: los resultados se analizaron mediante estadística multivariada para establecer asociaciones entre variables. Se halló una correlación positiva entre actividad laboral y desbalance oxidativo y entre elevado consumo energético, bajo consumo de alimentos fuente de micronutrientes antioxidantes, sedentarismo, alteración del perfil lipídico y EO; y se encontró una relación positiva entre bajo consumo de energía, perfil lipídico normal y adecuado consumo de frutas y verduras con un estado oxidativo normal.Conclusiones: los resultados muestran que cambios en los hábitos higiénico-dietéticos podrían ofrecer una protección a sujetos expuestos a agentes oxidantes.

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Supplementation with vitamins C, E, β‐carotene and selenium has no effect on anti‐oxidant status and immune responses in allergic adults: a randomized controlled trial

Abstract: Supplementation with anti-oxidants resulted in significantly increased levels of vitamin C, vitamin E, beta-carotene and selenium but no change in immune responses, serum AC or plasma F(2)-isoprostanes.

Cited by 49 publications

References 33 publications

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control

Valoración nutricional como complemento de los estudios en población expuesta a agentes oxidantes

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