Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females

Abstract

Background: Obesity is a global health problem, increasing susceptibility to Type 2 Diabetes (T2DM) and Cardiovascular Disease (CVD). Varieties of products have been proposed for treatment with varying degrees of success. Recent studies, suggested Oligonol; an optimized phenolic product mixture from Lychee Fruit Polyphenols (LFP); as such treatment in Japanese population.Objectives: We aimed to investigate the effect of oligonol on weight, insulin resistance by (HOMA-IR), lipids profile, leptin, Adiponectin, and resistin in healthy overweight and obese Saudi females.Subjects and Methods: 60 Saudi healthy overweight and obese females were enrolled in a double blind case/control study to take either Oligonol or placebo for 12 weeks without dietary or lifestyle re-strictions. Weight, height, Waist Circumference (WC), hip circumference (HC), and blood pressure were measured, and fasting blood samples of participants were taken before, and at the end of study. Total cholesterol, HDL-cholesterol, triglycerides, glucose, insulin, leptin, adiponectin, and resistin were meas-ured. LDL- cholesterol, HOMA-IR were calculated by equation.Results: 47 subjects completed the study, 25 in placebo group, and 22 in Oligonol group. No ill effects were noted in any participant. Oligonol reduced means of serum triglycerides (P=0.008), and resistin (P=0.045) significantly. In addition, no weight gain was noted in oligonol group, unlike placebo group which exhibited significant increase in mean weight (P= 0.036), WC (P=0.027), HC (P= 0.047), and leptin (P <0.001).Conclusion: Oligonol could be suggested as future hypolipidemic and weight controlling agent for overweight and obese Saudi females.

Effect of oligonol, a lychee‐derived polyphenol, on skeletal muscle in ovariectomized rats by regulating body composition, protein turnover, and mitochondrial quality signaling

“…to control body weight and improve the blood lipid profile in obese women (Bahijri et al, 2018). Specifically, oligonol inhibited intramuscular lipid accumulation by increasing the AMPKα activity and PPARα expression (Liu et al, 2017).…”

“…In a clinical trial, administration of polyphenols extracted from Ecklonia cava reduced fat mass and regulated lipid metabolism in subjects with abdominal obesity (Lee et al., 2018). Similarly, oligonol supplementation has been shown to control body weight and improve the blood lipid profile in obese women (Bahijri et al., 2018). Specifically, oligonol inhibited intramuscular lipid accumulation by increasing the AMPKα activity and PPARα expression (Liu et al., 2017).…”

Fornecimento Distribuído De Água: Uma Analogia Didática

“…De acordo com o Departamento de Agricultura dos Estados Unidos (USDA), uma dose de 100 gramas de lichia equivale a 66 kcal (USDA, 2019). Entre muitos compostos, o oligonol (polifenol) extraído deste fruto exibe efeitos antioxidantes, diuréticos e antiobesidade (Bahijri et al, 2018). Não obstante à sua composição nutricional, este fruto também é reconhecido pelo seu elevado teor de compostos nutracêuticos (não-nutrientes), tais como ácidos fenólicos, flavonoides, taninos e carotenoides (Shirahigue e Ceccato-Antonini, 2020;Reyes et al, 2016).…”

Lychee (Litchi chinensis Sonn.), the King of Fruits, with Both Traditional and Modern Pharmacological Health Benefits

“…Other studies have shown that lychee seeds also exhibited anti-influenza virus and reducing visceral obesity properties. 37 Bahijri et al 38 reported that oligonol could be useful as future hypolipidemic and weight controlling agent for overweight and obese females. Some researchers have shown the lychee fruit pulp extract (alcoholic and aqueous) has hepatoprotective activity against toxins such as carbon tetrachloride (CCl 4 ) in addition to its proven anti-apoptosis and anti-lipid peroxidation affects.…”