Supplementation with <i>Lactobacillus rhamnosus</i> or <i>Bifidobacterium lactis</i> probiotics in pregnancy increases cord blood interferon‐γ and breast milk transforming growth factor‐β and immunoglobin A detection

Prescott, Susan L.; Wickens, Kristin; Westcott, L.; Jung, W.; Currie, Helen; Black, Peter; Stanley, Thorsten; Mitchell, Edwin A.; Fitzharris, Penny; Siebers, Robert; Lian, Wei; Crane, Julian

doi:10.1111/j.1365-2222.2008.03061.x

Cited by 183 publications

(171 citation statements)

References 38 publications

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“…Previous studies have shown that probiotic supplementation during lactation increases the IgA levels in human milk and mouse milk. 21,22) However, there is a concern that probiotic consumption has the potential to cause systemic infections, which has been supported by several reports of safety concerns relating to probiotic use in immunocompromised hosts such as infants and pregnant women. Another concern is that probiotic bacteria cannot function as efficiently as desired in the absence of prebiotics, which are nondigestible dietary components that beneficially affect the host by selectively stimulating the growth and/or activity of one type or a limited number of types of bacteria.…”

Section: Discussionmentioning

confidence: 95%

1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice

Jinno

Nakamura

Nagata

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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To examine the effect of dietary supplementation with 1-kestose on the IgA levels in milk, BALB/c mice were fed diets with or without 5% 1-kestose during pregnancy and lactation. The total and specific IgA levels in the milk were measured at 7 and 14 days after delivery. A two-way ANOVA with repeated measures resulted in a significant effect of 1-kestose-supplementation on total IgA concentrations (p < 0.05) and the level of anti-Bacteroides IgA (p < 0.05). A significant positive correlation was found between the mean count of Bacteroides spp. in maternal feces and the total IgA concentration in maternal milk (r = 0.55, p < 0.05), suggesting a potential link between the gut and mammary gland immune system. In conclusion, this study demonstrated the effects of dietary prebiotics on milk IgA production.

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Section: Discussionmentioning

confidence: 95%

1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice

Jinno

Nakamura

Nagata

et al. 2014

Bioscience, Biotechnology, and Biochemistry

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“…Evidence of increased CRP, total IgE, and IL-10 levels, which are characteristic of a low-grade inflammation has been presented [66]. Another study decreased that after supplementation during pregnancy with L. rhamnosus and B. lactis, IFN-γ in cord blood increased [67]. Anti-CD3/CD28-induced IL-2 mRNA expression at 13 months of age was showed after probiotic supplementation at weaning [68].…”

Section: What Are the Mechanisms Behind Probiotics In Allergy Preventmentioning

confidence: 90%

Lactobacillus reuteri, Infant Allergy Prevention and Childhood Immune Maturation

Forsberg¹

2016

Probiotics and Prebiotics in Human Nutrition and Health

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The increasing allergy prevalence in affluent countries may be caused by reduced microbial stimulation, resulting in an abnormal postnatal immune maturation. This chapter concerns the theories behind the use of probiotics in randomized prevention trials, and how this supplementation affects the immunity of pregnant women, the immune development in their children, and possibly preventing allergic diseases. Most studies investigating the underlying mechanisms have focused on postnatal microbial exposure. An increasing body of evidence from studies suggests that the maternal microbial environment during pregnancy can program the immune development of the child. In human allergy intervention studies, probiotic supplementation to the mother during pregnancy, as well as to her baby postnatally, may be important for preventive effects. Also, prenatal environmental exposures may alter gene expression via epigenetic mechanisms, aiming to induce physiological adaptations to the anticipated postnatal environment. The maternal microbial environment during pregnancy may program the immune development of the child.

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“…Было показано, что прием некоторых пробиоти-ческих штаммов, принадлежащих к разным видам, таких как Lactobacillus rhamnosusor Bifidobacterium animalis subsp. lactis, на поздних сроках беременности и/или грудное вскармливание увеличивает IgA и уровни TGF-β2 в моло-ке [28,29]. Увеличение уровней IgA может помочь ограни-чить доступ бактерий, вызывающих мастит, в эпителий молочной железы, а TGF-β2 является ключевым иммуно-регуляторным фактором молочной железы, способствую-щим локальной выработке IgA и стимулирующим меха-низмы пероральной толерантности у младенцев.…”

Section: мастит: мишень для пробиотиков?unclassified

Mastitis in women: a new look at the old problem

Родригес¹

2017

Med. sov.

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Хуан М. РОДРИГЕС, доктор, Департамент по вопросам питания, диетологии и пищевых технологий, Мадридский университет Комплутенсе, Испания МАСТИТ У ЖЕНЩИН:НОВЫЙ ВЗГЛЯД НА СТАРУЮ ПРОБЛЕМУ Грудное молоко содержит представители микробиоты, влияющие не только на здоровье ребенка, но и на состояние молочных желез кормящей женщины как в краткосрочной, так и в долгосрочной перспективе. По сути, дисбиоз микробио-ты грудного молока, вызванный нарушенным состоянием здоровья материнского организма, а также воздействием микробиологических и медицинских факторов, часто способствует развитию острого, подострого или субклинического мастита -патологии, которая нередко приводит к прекращению грудного вскармливания. Устойчивость к антибиотикам, способность к формированию биопленок, связыванию железа, а также влияние на иммунный ответ хозяина являются общими чертами современных бактериальных возбудителей (в основном стафилококков, стрептококков и коринебакте-рий), вызывающих в т. ч. и мастит. Это объясняет, почему человек становится невосприимчивым к антибактериальной терапии и почему разработка новых направлений лечения мастита на основе пробиотиков становится очень привлека-тельной. Некоторые штаммы лактобактерий, выделенных из молока, уже показали высокую эффективность для профи-лактики и лечения мастита у кормящих женщин.

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Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon‐γ and breast milk transforming growth factor‐β and immunoglobin A detection

Abstract: The findings suggest that supplementation with probiotics in pregnancy has the potential to influence fetal immune parameters as well as immunomodulatory factors in breast milk.

Cited by 183 publications

References 38 publications

1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice

1-Kestose consumption during pregnancy and lactation increases the levels of IgA in the milk of lactating mice

Lactobacillus reuteri, Infant Allergy Prevention and Childhood Immune Maturation

Mastitis in women: a new look at the old problem

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