Supplementation with a recombinant human chorionic gonadotropin microdose leads to similar outcomes in ovarian stimulation with recombinant follicle-stimulating hormone using either a gonadotropin-releasing hormone agonist or antagonist for pituitary suppression

Cavagna, M.; Maldonado, L.G.; Bonetti, T.C.; Braga, Daniela Paes de Almeida Ferreira; Iaconelli, Assumpto; Borges, Edson

doi:10.1016/j.fertnstert.2009.02.075

Cited by 11 publications

(3 citation statements)

References 37 publications

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“…During fresh cleavage-stage embryo transfer, the embryo will be prematurely exposed to the luteal environment, which is suitable for blastocyst embryo implantation. [13–15] The study of Cavagna et al [16] showed that the uterine contraction frequency gradually decreases after hCG injection; at blastocyst transfer, a nearly quiescent state in the uterus can avoid embryo translocation in the uterine cavity, which is more conducive to embryo implantation. Genomics has indicated that blastocyst culture can reduce the aneuploidy formation rate.…”

Section: Discussionmentioning

confidence: 99%

Comparative study on the pregnancy outcomes of in vitro fertilization–embryo transfer between patients with different ovarian responses (a STROBE-compliant article)

Jin

et al. 2019

Medicine

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There have been few studies on large-sample data of cleavage-stage embryo and blastocyst transfers. We compared the pregnancy outcomes of patients with different ovarian responses after the transfer of different numbers of embryos in different developmental stages. Patients were divided into 3 groups including low response group, medium response group, and high response group according to different ovarian responses. Patients in each group were further divided into 4 subgroups including group A: transfer of 1 D3 embryo, group B: transfer of 2 D3 embryos; group C: transfer of 1 D5 blastocyst; and group D: transfer of 2 D5 blastocysts. In low ovarian responders, the implantation rate, clinical pregnancy rate and live birth rate were significantly lower in the group A than in the groups B and C. In medium ovarian responders, the implantation rate was significantly higher, but the multiple pregnancy rate was significantly lower in the group C than in the group B. The multiple pregnancy rate was significantly higher in the group D than in the group C. In high ovarian responders, the implantation rate was significantly lower, but the multiple pregnancy rate was significantly higher in the group B than in group C. Based on the above results, the single blastocyst transfer is preferable for the patients with different ovarian responses.

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Section: Discussionmentioning

confidence: 99%

Comparative study on the pregnancy outcomes of in vitro fertilization–embryo transfer between patients with different ovarian responses (a STROBE-compliant article)

Jin

et al. 2019

Medicine

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“…The use of molecules with LH activity in ovarian stimulation was initially proposed with low daily doses of human menopausal gonadotropin (hMG), followed by other studies showing that low doses of rhCG in the late follicular phase are able to complete follicular maturation, even in the absence of rFSH ( Filicori et al , 2002 , Filicori et al , 2005 , Cavagna et al , 2010 ). Previous studies have showed that the supplementation or substitution of FSH by hCG in the final stages of COS results in a >20% reduction of FSH consumption, yielding a significant cost reduction, without compromising ICSI outcome as compared to traditional COS regimens ( Fabregues et al , 2005 , Filicori et al , 2005 , Cavagna et al , 2010 ). Therefore, we aimed at evaluating if the GnRHa short protocol in alternate days associated with rhCG microdoses for ovarian stimulation would result in satisfactory IVF outcomes at a reduced cost.…”

Section: Discussionmentioning

confidence: 99%

“…). Previous studies have showed that the supplementation or substitution of FSH by hCG in the final stages of COS results in a >20% reduction of FSH consumption, yielding a significant cost reduction, without compromising ICSI outcome as compared to traditional COS regimens (Fabregues et al, 2005, Filicori et al, 2005, Cavagna et al, 2010. Therefore, we aimed at evaluating if the GnRHa short protocol in alternate days associated with rhCG microdoses for ovarian stimulation would result in satisfactory IVF outcomes at a reduced cost.…”

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confidence: 99%

Pituitary suppression with a GnRHa short protocol in an alternate day schedule associated with rhCG microdoses

Rodrigues¹,

Setti²,

Braga³

et al. 2014

JBRA Assisted Reproduction

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Objective: To evaluate a comfortable short protocol with GnRH agonist (GnRHa) in alternate days, with a step down method of gonadotropins administration associated with hCG microdose for young patients undergoing intracytoplasmic sperm injection. Methods: This study evaluated 89 ICSI cycles performed in female patients aged <36 years. Patients were submitted to a short protocol with GnRHa schedule in the study group (n= 25) and to a long pituitary suppression protocol in the control group (n=64). Results: The total dose of rFSH administered as well as estradiol levels on the day of hCG trigger were significantly lower in the short protocol group. There were no significant differences between the groups regarding the fertilization, high-quality embryos, implantation, pregnancy and miscarriage rates. However, mean ovarian stimulation cost

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Efficacy of low-dose hCG in late follicular phase in controlled ovarian stimulation using GnRH agonist protocol

Aflatoonian

Yousefnejad

Eftekhar

et al. 2012

Arch Gynecol Obstet

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Supplementation with a recombinant human chorionic gonadotropin microdose leads to similar outcomes in ovarian stimulation with recombinant follicle-stimulating hormone using either a gonadotropin-releasing hormone agonist or antagonist for pituitary suppression

Cited by 11 publications

References 37 publications

Comparative study on the pregnancy outcomes of in vitro fertilization–embryo transfer between patients with different ovarian responses (a STROBE-compliant article)

Comparative study on the pregnancy outcomes of in vitro fertilization–embryo transfer between patients with different ovarian responses (a STROBE-compliant article)

Pituitary suppression with a GnRHa short protocol in an alternate day schedule associated with rhCG microdoses

Efficacy of low-dose hCG in late follicular phase in controlled ovarian stimulation using GnRH agonist protocol

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