Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants

Samara, Jumana; Moossavi, Shirin; Alshaikh, Belal; Ortega, Van A.; Pettersen, Veronika Kuchařová; Ferdous, Tahsin; Hoops, Suzie; Soraisham, Amuchou; Vayalumkal, Joseph; Dersch‐Mills, Deonne; Gerber, Jeffrey S.; Mukhopadhyay, Sagori; Puopolo, Karen M.; Tompkins, Thomas A.; Knights, Dan; Walter, Jens; Amin, Harish; Arrieta, Marie‐Claire

doi:10.1016/j.chom.2022.04.005

Cited by 79 publications

(66 citation statements)

References 88 publications

(142 reference statements)

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“…In particular, Akkermansia and Bifidobacterium are recognized as beneficial microbiota in the gut. 32,33 2′-FL as a Beneficial Ingredient Affects the Diversity and Structure of the Gut Microbiota in HMA Mice. The gut microbiota composition of the mice under different feeding methods was obtained using 16S rRNA sequencing technology.…”

Section: ■ Resultsmentioning

confidence: 99%

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2′-Fucosyllactose Promotes the Production of Short-Chain Fatty Acids and Improves Immune Function in Human-Microbiota-Associated Mice by Regulating Gut Microbiota

Chen

Yin

Xie³

et al. 2022

J. Agric. Food Chem.

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As a natural prebiotic in human milk, 2′-fucosyllactose (2′-FL) is actively used in infant formula (IF). However, the 2′-FL influence on the improvement of gut microbiota and the regulation of the immune function remains unknown. In this study, human microbiota-associated (HMA) mice were used to demonstrate that feeding 2′-FL-containing IF was comparable to human milk at levels of immune cytokines (IL-2, IL-9, IL-10, and sIgA) and short-chain fatty acids (SCFAs, i.e., acetate and propionate). In addition, 2′-FL increased the abundance of Blautia and Olsenella and improved the anti-inflammatory cytokine IL-10 levels. The abundance of Blautia and Olsenella positively correlated with the IL-10 levels. 2′-FL also decreased the abundance of Enterorhabdus and Lachnospiraceae_UCG-006 and elevated SCFA levels, showing a negative correlation between these genera and SCFAs. Our findings revealed that feeding 2′-FL-containing IF drives the levels of cytokines and SCFAs toward human milk levels by shaping the beneficial gut microbiota profile.

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Section: ■ Resultsmentioning

confidence: 99%

“…At the genus level, FMT operation improved the effects of the antibiotics on the major genera, including Enterorhabdus, Akkermansia, and Bifidobacterium (Figure B). In particular, Akkermansia and Bifidobacterium are recognized as beneficial microbiota in the gut. , …”

Section: Resultsmentioning

confidence: 99%

2′-Fucosyllactose Promotes the Production of Short-Chain Fatty Acids and Improves Immune Function in Human-Microbiota-Associated Mice by Regulating Gut Microbiota

Chen

Yin

Xie³

et al. 2022

J. Agric. Food Chem.

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“…qPCR was used to detect the specific bacteria that correlated to disease or intestinal health in the clinic ( 203 ). Moreover, the occurrence of NGS and metagenomic sequencing of the microbiome helps us investigate the microbial composition deeply ( 204 ), and the different methods of analysis such as via a co-occurrence network, functional annotation, and random forest ( 181 , 205 ) help us predict the maturation of the intestinal microbiome and exploit new probiotics for infants.…”

Section: Discussionmentioning

confidence: 99%

“…reduced the risk of NEC, late-onset invasive infection, and mortality in very-preterm or very-low-birth-weight infants ( 180 ). Moreover, the intervention that combined Bifidobacterium and Lacticaseibacillus accelerated microbial maturation such as α-diversity, stability, and interconnectivity and reduced the inflammatory response in extremely preterm infants ( 181 ). Probiotics are an effective strategy to prevent gastrointestinal disease in infants, and research showed that 14% of intensive care units administered probiotics to low-birth-weight premature babies between May and September 2015 in the USA ( 182 ).…”

Section: Ways To Early Intervenementioning

confidence: 99%

Effect of the Microbiome on Intestinal Innate Immune Development in Early Life and the Potential Strategy of Early Intervention

Yang

Liu

et al. 2022

Front. Immunol.

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Early life is a vital period for mammals to be colonized with the microbiome, which profoundly influences the development of the intestinal immune function. For neonates to resist pathogen infection and avoid gastrointestinal illness, the intestinal innate immune system is critical. Thus, this review summarizes the development of the intestinal microbiome and the intestinal innate immune barrier, including the intestinal epithelium and immune cells from the fetal to the weaning period. Moreover, the impact of the intestinal microbiome on innate immune development and the two main way of early-life intervention including probiotics and fecal microbiota transplantation (FMT) also are discussed in this review. We hope to highlight the crosstalk between early microbial colonization and intestinal innate immunity development and offer some information for early intervention.

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“…Numerous studies have shown that foods containing probiotics, such as dairy and soybean products, are easily absorbed by the body, with high nutritional value, and have health benefits [ 9 , 10 ]. Supplementation with a combination of probiotics accelerates the maturation of gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants [ 11 ]. In addition, probiotics metabolize a variety of bioactive substances during fermentation of food, which contribute to human health [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Probiotic Properties Including the Antioxidant and Hypoglycemic Ability of Lactic Acid Bacteria from Fermented Grains of Chinese Baijiu

Fan

Xue

Bai

et al. 2022

Foods

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In this study, lactic acid bacteria (LAB) strains were isolated from fermented grains of traditional Chinese Baijiu, and their probiotic properties were characterized. Eleven out of 29 LAB strains showed good tolerance to the gastrointestinal tract and bile salts. The surface characteristics (auto-aggregation, co-aggregation, hydrophobicity), safety (hemolytic and antibiotic sensitivity), antibacterial activity against three foodborne pathogens, and antioxidant and hypoglycemic properties of the 11 LAB strains were investigated. Principal component analysis (PCA) was used to comprehensively evaluate LAB strains and their probiotic properties. It was found that Weissella cibaria (OP288150), Pediococcus acidilactici (OP288151), Pediococcus pentosaceus (OP288154), Pediococcus pentosaceus (OP288156) and Levilactobacillus brevis (OP288158) showed high probiotic properties, with potential for commercial development. The results also demonstrated that fermented grains of Chinese Baijiu can be used as a source of high-quality probiotics.

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Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants

Cited by 79 publications

References 88 publications

2′-Fucosyllactose Promotes the Production of Short-Chain Fatty Acids and Improves Immune Function in Human-Microbiota-Associated Mice by Regulating Gut Microbiota

2′-Fucosyllactose Promotes the Production of Short-Chain Fatty Acids and Improves Immune Function in Human-Microbiota-Associated Mice by Regulating Gut Microbiota

Effect of the Microbiome on Intestinal Innate Immune Development in Early Life and the Potential Strategy of Early Intervention

Probiotic Properties Including the Antioxidant and Hypoglycemic Ability of Lactic Acid Bacteria from Fermented Grains of Chinese Baijiu

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