Supplementation of Ω‐3 Fatty Acids in Parenteral Nutrition Beneficially Alters Phospholipid Fatty Acid Pattern

Abstract

Omega-3-fatty-acids-supplemented fat emulsions for parenteral administration are safe and very well tolerated. This study demonstrates that parenteral administration of omega-3-PUFA-enriched fat emulsions leads to increased incorporation of EPA and DHA into phospholipids in serum and erythrocytes, whereas AA levels remain unchanged. Thus, postoperative parenteral administration of omega-3-PUFA-enriched lipid emulsions could have an impact on the postoperative inflammatory response after abdominal surgery and could be used in standard postoperative care when PN is indicated.

Estrogen and n-3 polyunsaturated fatty acid supplementation have a synergistic hypotriglyceridemic effect in ovariectomized rats

“…The present study also showed that ERa and ERb were present in both nuclear and cytosolic compartments, but, in skeletal muscle, localization was preferential to the cytosol, which includes the cellular membrane. Therefore, the effect of n-3 PUFAs on ERs could be indirect, because n-3 PUFA can incorporate into the cell membrane and affect membrane fluidity and permeability (Senkal et al 2007;Armstrong et al 2003).…”

Parenteral Nutrition Enriched with Fish Oil after Gastrointestinal Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…Among 17 studies, 11 studies [2,11,12,23,24,26,27,29,30,32,33] used an adequate approach to sequence generation using computer generated random numbers or random-number tables. The adequacy of randomization was unclear in the remaining 6 studies.…”

“…Figure 1 shows the process for identifying potentially eligible studies and exclusion criteria. After elaborative screening, 34 articles were assessed by full text and 17 studies with 753 patients [2,[10][11][12]15,16,[23][24][25][26][27][28][29][30][31][32][33] were included for the review. However, three publications [2,24,30,31,33] are same study that reported different outcomes.…”

“…Nine studies reported the occurrence of infectious postoperative complications [11,12,23,26,27,[29][30][31][32]. The incidence of infection was 8.8% in the intervention group (24/273) and 20.1% in the control group (56/271).…”

“…The analysis of three studies [10,15,29] showed a significant increase in concentrations of EPA and DHA within the intervention group compared with the control group. The standard mean difference for EPA was 5.41 (95% CI, 2.47 to 8.34, P = 0.0003, heterogeneity I 2 = 88%) and DHA was 3.20 (95% CI, 1.27 to 5.14, P = 0.001, heterogeneity I 2 = 87%).…”