Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway

Zhao, Beita; Ren, Bo; Guo, Rui; Zhang, Wentong; Ma, Shaobo; Yao, Yuchen; Tian, Yuan; Liu, Zhigang; Liu, Xuebo

doi:10.1016/j.fct.2017.09.050

Cited by 139 publications

(80 citation statements)

References 53 publications

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“…In contrast, neither corneocyte desquamation level nor bacterial presence in the RSSC increased during dietary intervention with lycopene-enriched ice cream. Interestingly, convincing experimental evidence exists demonstrating that lycopene inhibits proinflammatory cytokines, including IL-1β (Palozza et al, 2011;Zhao et al, 2017); thus, our results can be interpreted as a manifestation of antioxidant and anti-inflammatory lycopene action at the level of the facial skin. The observed prevention of bacterial overgrowth by lycopene may be caused by sebum production normalization; however, direct antibacterial action of the carotenoid is impossible to exclude, as it was certainly present in the sebum of our volunteers during consumption of lycopene-enriched ice cream.…”

Section: Discussionsupporting

confidence: 60%

Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study

Чернышова

Pristenskiy

Lozbiakova

et al. 2019

Journal of Dairy Science

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The health-promoting dietary antioxidant lycopene has limited natural bioavailability, but lycopene-rich functional foods can improve its bioavailability. We assessed a new lycopene-enriched ice cream for systemic antioxidant effects and influence on morphological characteristics of facial skin surface in healthy volunteers. In a randomized crossover study, we used 4-wk dietary interventions with either control or lycopeneenriched ice cream. Samples of serum and residual skin surface components (RSSC) from facial skin were taken before interventions, at 2 wk, and at intervention end. Lycopene concentration, conventional blood biochemistry, and oxidative stress biomarkers comprising inflammatory oxidative damage and low-density lipoprotein peroxidase proteins were assessed in the serum. Lycopene-associated immunofluorescence, lipid droplet size, corneocyte desquamation, and microbial presence were measured in the RSSC. The results show that lycopene concentrations in the serum and skin steadily increased during lycopene-enriched ice cream consumption. Whereas we found no intervention-dependent changes in conventional biochemical parameters, both inflammatory oxidative damage and low-density lipoprotein peroxidase protein values significantly decreased by the end of intervention with lycopene-enriched ice cream, but remained unchanged during control ice cream consumption. Control ice cream significantly increased corneocyte desquamation and bacterial presence in the RSSC. These adverse effects, which could potentially predispose consumers to acne development, were absent when volunteers consumed lycopene-enriched ice cream. We concluded that lycopene-enriched ice cream is a new functional food with clear antioxidant properties. In addition, enrichment with lycopene may alleviate proinflammatory action of ice cream at the level of facial skin, thus decreasing diet-associated acne development risk in young consumers.

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Section: Discussionsupporting

confidence: 60%

Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study

Чернышова

Pristenskiy

Lozbiakova

et al. 2019

Journal of Dairy Science

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“…In a study conducted by Wang et al [99] on mice receiving proinflammatory and antioxidative liposaccharide, it was observed that apart from improving cerebral antioxidative status, lycopene can also mitigate inflammations occurring in the nervous system, amylogenesis and cognitive impairment, most likely by mediating the signal pathways for MAPK (mitogen-activated protein kinases), nuclear factor κB, and Nrf2 (nuclear factor-erythroid 2-related factor 2). Behavioral tests, including Y maze test, locomotor activity, and Morris water maze test, revealed that long-term supplementation with lycopene (50 mg kg −1 body mass daily) mitigated the cognitive disorders induced with d-galactose in male CD-1 mice [100]. The use of lycopene prevented histopathological damage and restored the levels of the neurotrophic factor originating from the brain in the mice's hippocampus.…”

Section: Vitamins and Provitaminsmentioning

confidence: 96%

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

et al. 2020

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Neurodegenerative diseases are progressive diseases of the nervous system that lead to neuron loss or functional disorders. Neurodegenerative diseases require long-term, sometimes life-long pharmacological treatment, which increases the risk of adverse effects and a negative impact of pharmaceuticals on the patients' general condition. One of the main problems related to the treatment of this type of condition is the limited ability to deliver drugs to the brain due to their poor solubility, low bioavailability, and the effects of the blood-brain barrier. Given the above, one of the main objectives of contemporary scientific research focuses on the prevention of neurodegenerative diseases. As disorders related to the competence of the antioxidative system are a marker in all diseases of this type, the primary prophylactics should entail the use of exogenous antioxidants, particularly ones that can be used over extended periods, regardless of the patient's age, and that are easily available, e.g., as part of a diet or as diet supplements. The paper analyzes the significance of the oxidoreductive balance in the pathogenesis of neurodegenerative diseases. Based on information published globally in the last 10 years, an analysis is also provided with regard to the impact of exogenous antioxidants on brain functions with respect to the prevention of this type of diseases.

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“…It seems important to note that the neuroprotective effect of HO-1 induction is mainly due to the Nrf2-dependent activation, as widely discussed earlier in this review. In ageing as well, for instance, there is evidence that the Nrf2-dependent HO-1 up-regulation due to the treatment with flavonoids or carotenoids is protective against galactose-induced ageing-like neurodegeneration [110,111] and that voluntary running, through the up-regulation of HO-1, improves age-related cognitive decline in rats [112]. The role played by Nrf2 in ageing and neurodegenerative diseases has been widely reviewed elsewhere and there is a general agreement on the fact that in older organisms there is a decline of Nrf2 activity [113].…”

Section: Ho-1 Up-regulation In Neurodegenerationmentioning

confidence: 99%

Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?

Nitti

Piras

Brondolo

et al. 2018

IJMS

119

107

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Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress. Under control of different transcription factors but with a prominent role played by Nrf2, HO-1 induction is crucial also in nervous system response to damage. However, several lines of evidence have highlighted that HO-1 expression is associated to neuronal damage and neurodegeneration especially in Alzheimer’s and Parkinson’s diseases. In this review, we summarize the current literature regarding the role of HO-1 in nervous system pointing out different molecular mechanisms possibly responsible for HO-1 up-regulation in nervous system homeostasis and neurodegeneration.

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Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-κB transcriptional pathway

Cited by 139 publications

References 53 publications

Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study

Systemic and skin-targeting beneficial effects of lycopene-enriched ice cream: A pilot study

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?

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