Supplementation of Lactobacillus plantarum (TCI227) Prevented Potassium-Oxonate-Induced Hyperuricemia in Rats

Chien, Chih-Yu; Chien, Yu-Jou; Lin, Yun‐Lian; Lin, Gong‐Ru; Chan, Shun‐Yu; Hu, Wei-Chun; Wu, Han-Fang; Chiang, Chi-Fu; Hsu, Chin‐Lin

doi:10.3390/nu14224832

Cited by 15 publications

(10 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The animal procedure con rmed the anti-hyperuricemic capability of the strain. The serum UA in mice could be decreased by 35.5% and close to the normal level with the treatment of X7022, and the UA reduction is higher than that of L. plantarum TCI227 (about 23%) [25], similar to that L. plantarum KGM3 (39%) at the dose of 2 × 10 9 CFU/kg [24]. Besides, the strain could reduce BUN and creatinine during the lowering UA in hyperuricemic mice.…”

Section: Discussionmentioning

confidence: 77%

WITHDRAWN: The anti-hyperuricemic and gut microbiota regulatory effects of a novel purine assimilatory probiotic strain

Yuan

Jiang

et al. 2023

Preprint

View full text Add to dashboard Cite

Lactiplantibacillus plantarum X7022, a novel probiotic strain, exhibited gastrointestinal viability as 44% at the dose of 109 CFU/mL in mice. The strain possesses a complete purine assimilation pathway and can exhaust xanthine, guanine, and adenine by 82.1%, 33.1%, and 12.6%, respectively. After four-week administration of the strain, a significant decrease of 35.5% in the serum uric acid level in potassium oxonate and hypoxanthine induced hyperuricemic mice was realized. The activity of hepatic xanthine oxidase was normalized. Furthermore, the expression of glucose transporter 9 and urate transporter 1 were downregulated by 12.4% and 37.6%, while organic anion transporter 1 was upregulated by 23.4% in kidney. The treatment also alleviated renal inflammation and restored renal damage. Importantly, the strain played critical roles on improving gut microbiota dysbiosis in hyperuricemic mice through depressing inflammation or hyperuricemia related flora and promoting the abundance of short-chain fatty acid (SCFA) production-related flora. As a result, the diminished fecal SCFAs contents were remarkably elevated. Therefore, L. plantarum X7022 is a promising probiotic strain for ameliorating hyperuricemia.

show abstract

Section: Discussionmentioning

confidence: 77%

WITHDRAWN: The anti-hyperuricemic and gut microbiota regulatory effects of a novel purine assimilatory probiotic strain

Yuan

Jiang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…L. plantarum TCI227 can reduce uric acid levels and regulate the composition of intestinal flora, which increased Lactobacillaceae and decreased Deferribacteres and Prevotellaceae . The reduction of uric acid levels by L. plantarum TCI227 may be related to the regulation of gut microbiota [52]. Yamanaka et al [53] found that yoghurt with Lactobacillus PA-3 could improve uric acid levels in healthy people, patients with hyperuricemia and gout, and further found that probiotics rich in yoghurt played a vital role in regulating blood uric acid.…”

Section: New Proposals For Gout Therapymentioning

confidence: 99%

Gut microbiota plays a significant role in gout

Feng,

Wang,

Xin

et al. 2024

Journal of Medical Microbiology

View full text Add to dashboard Cite

With the development of social economy, the incidence of gout is increasing, which is closely related to people’s increasingly rich diet. Eating a diet high in purine, fat, sugar and low-fibre for a long time further aggravates gout by affecting uric acid metabolism. The renal metabolism mechanism of uric acid has been thoroughly studied. To find a new treatment method for gout, increasing studies have recently been conducted on the mechanism of intestinal excretion, metabolism and absorption of uric acid. The most important research is the relationship between intestinal microbiota and the risk of gout. Gut microbiota represent bacteria that reside in a host’s gastrointestinal tract. The composition of the gut microbiota is associated with protection against pathogen colonization and disease occurrence. This review focuses on how gut microbiota affects gout through uric acid and discusses the types of bacteria that may be involved in the occurrence and progression of gout. We also describe potential therapy for gout by restoring gut microbiota homeostasis and reducing uric acid levels. We hold the perspective that changing intestinal microbiota may become a vital method for effectively preventing or treating gout.

show abstract

“…The timing and method of intervention for HUA remain controversial, and their application is limited due to drug side effects (Chales 2019;Chien et al 2022;Mehmood et al 2019;Petreski et al 2020). As safer alternatives, probiotics hold great potential for preventing and treating hyperuricemia.…”

Section: Introductionmentioning

confidence: 99%

Preventive effect of Lactobacillus johnsonii YH1136 against uric acid accumulation and renal damages

Zhang,

Sun,

Xin

et al. 2024

Preprint

View full text Add to dashboard Cite

Hyperuricemia (HUA) is a prevalent metabolic disorder globally, and its development is increasingly associated with intestinal microbiota. Therefore, probiotics have emerged as a potential and safe approach for lowering uric acid (UA) levels. However, effective probiotic strains and the underlying mechanism remain unknown. Therefore, this study aims to investigate microbiota alterations in each intestinal segment during HUA to identify the most affected segment and potential probiotic strains. Whole intestinal diversity was significantly decreased in the model group than in the control, with the most significant decrease in the cecum and colon. Firmicutes, Bacteroidota, and Actinobacteriota were the dominant phyla common to the control and model groups, whereas Bacteroidota was more dominant in the colon of the model group than in the control group. In the RDA analysis, Lactobacillus in the colon and the model group exhibited a strong correlation, suggesting that Lactobacillus may play an important role in HUA. Consequently, Lactobacillus johnsonii YH1136 was used to assess its preventive effects against HUA. The results showed that Lactobacillus johnsonii YH1136 administration effectively reduced serum UA levels in vivo, mainly inhibiting hepatic xanthine oxidas(XOD) activity and promoting renal ABCG2 transporter expression.Moreover, increased colonization using Lactobacillus johnsonii YH1136 significantly ameliorated pathological damage in the kidney and liver, causing UA accumulation. These findings highlight the potential significance of Lactobacillus as a connection between HUA and the gut microbiota, providing compelling evidence for Lactobacillus johnsonii YH1136 as a potential treatment for HUA.

show abstract

Supplementation of Lactobacillus plantarum (TCI227) Prevented Potassium-Oxonate-Induced Hyperuricemia in Rats

Cited by 15 publications

References 47 publications

WITHDRAWN: The anti-hyperuricemic and gut microbiota regulatory effects of a novel purine assimilatory probiotic strain

WITHDRAWN: The anti-hyperuricemic and gut microbiota regulatory effects of a novel purine assimilatory probiotic strain

Gut microbiota plays a significant role in gout

Preventive effect of Lactobacillus johnsonii YH1136 against uric acid accumulation and renal damages

Contact Info

Product

Resources

About