Supplementation of L-arginine improves hypertension and lipid metabolism but not insulin resistance in diabetic rats

Kawano, Tomohito; Nomura, Masahiro; Nisikado, Akiyoshi; Nakaya, Yutaka; Ito, Susumu

doi:10.1016/j.lfs.2003.06.004

Cited by 18 publications

(15 citation statements)

References 28 publications

(24 reference statements)

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“…Indeed, the increase of NO production has been reported in the retina of long lasting streptozotocin-induced diabetic rats [18]. As the synthesis of NO has been shown to be dependent on the availability of extracellular arginine [19][20][21], membrane transport of arginine may represent a rate-limiting step in local retina NO production, and thus in NO action.…”

Section: Discussionmentioning

confidence: 99%

l-Arginine Uptake in Normal and Diabetic Rat Retina and Retinal Pigment Epithelium

2008

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Diabetes-induced increase in oxidative stress is postulated as playing a significant role in the development of retinopathy. The retinal pigment epithelium (RPE) which forms part of the retinal blood barrier has been reported to be affected in diabetes. Besides functioning as a neurotransmitter, the radical nitric oxide (NO) can act as a cytotoxic agent. NO is synthesized by nitric oxide synthase (NOS) that oxidizes arginine to citrulline producing NO. Given that intracellular concentration of arginine depends mainly on its transport, we studied arginine transport in RPE and retina from normal and streptozotocin-induced diabetic rats. Retina and RPE take up arginine by a saturable system with an apparent K(M) of 70-80 microM. Tissue incubation in the presence of insulin or high glucose concentrations significantly increased arginine transport in RPE but not in retina from control rats. Similarly, arginine uptake was enhanced in RPE, but not in the retina from streptozotocin-induced diabetic rats. However, NO content was two-fold higher in diabetic retina and RPE compared to that in the control rats. Such findings may suggest that diabetes induced an increase in NO levels in RPE, which may have brought about alterations in its functioning and in turn manifestations of diabetic retinopathy.

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Section: Discussionmentioning

confidence: 99%

l-Arginine Uptake in Normal and Diabetic Rat Retina and Retinal Pigment Epithelium

2008

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“…Thus, in streptozotocininduced diabetic rats, treatment with 2% arginine in their diet attenuated the elevated serum levels of triglyceride and LDL by about 20% [132]. Likewise, arginine treatment improved lipid metabolism in genetically diabetic and fatty rats [133]. Most recently, Fu et al [11] reported that a long-term arginine treatment reduced retroperitoneal fat mass by 45% and had no effect on the weight of other tissues in ZDF rats.…”

Section: Hypocholesterolemic Effect Of Nomentioning

confidence: 99%

Regulatory role for the arginine–nitric oxide pathway in metabolism of energy substrates

Jobgen

Fried

et al. 2006

The Journal of Nutritional Biochemistry

609

479

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“…These results agree with the previous reports from Dumont et al [11] who found that a low dose instead a high dose of L-arginine in drinking water significantly attenuates the development of hypertension in uraemic rats. Gouvêa et al [10] supported the hypothesis that in WK rats with renovascular hypertension L-arginine treatment (300 mg/day during 14 days) decreases the arterial pressure (23%) in the two-kidney, one-clip (2K1C) renovascular hypertension model induced hypertension rats, not only because of the already known vasodilator effects of NO formation, but also because there is an increase in renal excretion of water and sodium; Kawano et al [24] reported a significant reduction (11.3%) in systolic pressure in fed rats supplemented with 1.4% Larginine [24]. Nevertheless, Chang et al [12] reported that early in vitro studies using aorta or artery segments isolated from genetic and secondary hypertensive animals suggested that endothelium-dependent relaxation of blood vessels was impaired in hypertension.…”

Section: L-arginine Hypolipidemic Activitymentioning

confidence: 90%

Effect of L-arginine Oral Supplementation on Response to Myocardial Infarction in Hypercholesterolemic and Hypertensive Rats

Piñeiro

Ortiz-Moreno

Mora‐Escobedo

et al. 2010

Plant Foods Hum Nutr

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The well known metabolic functions of L-arginine have been recently increased with the discovery of its role as the substrate for the synthesis of nitric oxide (NO), which has emerged as an endogenous signaling molecule with potential therapeutic implications for cardiovascular disease. Steady-state levels of NO are derived in part from dietary sources. It has been reported that supplementation of L-arginine reduces atherosclerosis in rabbits and reduces the arterial pressure in hypertensive rats. Therefore, we investigated the effect of L-arginine supplementation using a group of induced hypercholesterolemic rats and a group of spontaneously hypertensive rats; the infarcted area in cardiac tissue of both groups was measured during the response to myocardial infarction in the ischemia-reperfusion model. Hypercholesterolemic rats supplemented with 170 mg kg(-1) of L-arginine showed a significant (P

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Supplementation of L-arginine improves hypertension and lipid metabolism but not insulin resistance in diabetic rats

Cited by 18 publications

References 28 publications

l-Arginine Uptake in Normal and Diabetic Rat Retina and Retinal Pigment Epithelium

l-Arginine Uptake in Normal and Diabetic Rat Retina and Retinal Pigment Epithelium

Regulatory role for the arginine–nitric oxide pathway in metabolism of energy substrates

Effect of L-arginine Oral Supplementation on Response to Myocardial Infarction in Hypercholesterolemic and Hypertensive Rats

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