Supplementation of <i>Kaempferia parviflora</i> Extract Enhances Physical Fitness and Modulates Parameters of Heart Rate Variability in Adolescent Student-Athletes: A Randomized, Double-Blind, Placebo-Controlled Clinical Study

Sripanidkulchai, Bungorn; Promthep, Kreeta; Tuntiyasawasdikul, Sarunya; Tabboon, Peera; Areemit, Rosawan

doi:10.1080/19390211.2020.1852356

Cited by 7 publications

(5 citation statements)

References 43 publications

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“…KP was able to inhibit fat accumulation and muscle atrophy [35], improve physical fitness and muscular endurance [36], and improve energy metabolism by activating brown adipose tissue [37] in mice models. The KP extract was also able to improve physical fitness, heart rate and oxygen consumption in a randomized doubleblind trial [38,39], reduce body fat [40] and the polymethoxyflavones from KP were found to reduce visceral fat area and subcutaneous fat area in another randomised, double-blind, placebo-controlled trial [41]. These reports fall parallel to the point that both KP and DMF could improve the healthspan.…”

Section: Discussionmentioning

confidence: 91%

DAF-16 and SKN-1 mediate Anti-aging and Neuroprotective efficacies of “thai ginseng” Kaempferia parviflora Rhizome extract in Caenorhabditis elegans

Prasanth

Malar

Brimson

et al. 2022

NHA

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BACKGROUND: The rhizomes of Kaempferia parviflora (KP), have been traditionally used for treating various ailments with 5,7-dimethoxyflavone (DMF) as a prominent compound. OBJECTIVE: To investigate the anti-aging and neuroprotective properties of KP and DMF in Caenorhabditis elegans. METHODS: C. elegans (wild-type (N2), transgenic and mutant strains) were treated with KP and DMF and were monitored for lifespan and neuroprotection through physiological assays, fluorescence microscopy and qPCR analysis. Molecular docking studies were employed to identify the interaction mode of DMF with DAF-16 and SKN-1. RESULTS: KP and DMF significantly increased the lifespan of N2 along with modulating pharyngeal pumping and lipofuscin accumulation. They also exhibited neuroprotection in Aβ transgenic strains by improving lifespan and delaying paralysis. Further, they reduced ROS accumulation significantly in worms exposed to UV-A, thereby exhibiting anti-photoaging potential. KP and DMF could activate SKN-1, DAF-16 which was evident from molecular docking and qPCR analysis. The DAF-2 and DAF-16 mutants did not exhibit any variations in lifespan upon treatment with KP and DMF suggesting the involvement of the DAF-16 mediated pathway in regulating the anti-aging and neuroprotective effects. CONCLUSION: Our findings suggest that KP with DMF as an active ingredient is a potential nutraceutical for aging and associated disorders.

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Section: Discussionmentioning

confidence: 91%

DAF-16 and SKN-1 mediate Anti-aging and Neuroprotective efficacies of “thai ginseng” Kaempferia parviflora Rhizome extract in Caenorhabditis elegans

Prasanth

Malar

Brimson

et al. 2022

NHA

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“…In this regard, other commonly used supplements such us creatine limits the parasympathetic modulation of the RT exercise [ 87 ], whereas caffeine has contradictory results by increasing the parasympathetic modulation after anaerobic exercise [ 88 ] but delaying parasympathetic recovery after aerobic exercise [ 89 ]. Other not as common supplements such as the black thai ginger show a similar effect to caffeine in the response of autonomic nervous system to anaerobic exercise [ 90 ]. In this sense, studies that combine different supplements are required.…”

Section: Discussionmentioning

confidence: 99%

Beetroot Juice Produces Changes in Heart Rate Variability and Reduces Internal Load during Resistance Training in Men: A Randomized Double-Blind Crossover

et al. 2022

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Beetroot juice (BJ) has been used as a sport supplement, improving performance in resistance training (RT). However, its effect on the modulation of the autonomic nervous system has not yet been widely studied. Therefore, the objective of this randomized double-blind crossover study was to assess the effect of acute BJ supplementation compared to placebo in blood pressure (BP), heart rate (HR), heart rate variability (HRV) and internal load during RT measure as Root Mean Square of the Successive Differences between adjacent RR intervals Slope (RMSSD and RMSSD-Slope, respectively). Eleven men performed an incremental RT test (three sets at 60%, 70% and 80% of their repetition maximum) composed by back squat and bench press with. HR, HRV and RMSSD-Slope were measured during and post exercise. As the main results, RMSSD during exercise decrease in the BJ group compared to placebo (p = 0.023; ES = 0.999), there were no differences in RMSSD post-exercise, and there were differences in RMSSD-Slope between groups in favor of the BJ group (p = 0.025; ES = 1.104) with a lower internal load. In conclusion, BJ supplementation seems to be a valuable tool for the reduction in the internal load of exercise during RT measured as RMSSD-Slope while enhancing performance.

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“…Autonomic nervous system is responsible for managing, in part, the heart rate; thus, due to neurological actions to preserve the organism’s homeostatic balance, the sympathetic and parasympathetic components generate variations in the intervals between heartbeats (from moment to moment), called RR intervals 1 , obtained by electrocardiograph or cardiofrequency meters 2 . Heart rate variability (HRV), a method that uses indices derived from RR intervals, is used to study the sympathetic and parasympathetic interaction of the autonomic nervous system in situations of health, disease, and human performance 3 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of the autonomic nervous system dysfunction between different chronic spine disorders: neck pain versus low back pain

Pontes‐Silva

Bassi‐Dibai

Gomes

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVE: This study aims to compare heart rate variability (HRV) between patients with chronic neck pain and patients with chronic low back pain and to correlate the chronic pain variables with heart rate variability indices. METHODS: This is a cross-sectional study. We divided the sample into two groups: neck pain (n=30) and low back pain (n=30). We used the Numeric Pain Rating Scale, Neck Disability Index, Roland-Morris Disability Questionnaire, Pain-Related Catastrophizing Thoughts Scale, Tampa Scale of Kinesiophobia, and Pain Self-Efficacy Questionnaire. For heart rate variability analysis, we used the following indices: mean RR, standard deviation of all RR intervals, mean heart rate, root mean square differences of successive RR intervals, triangular index, triangular interpolation of the interval histogram, low-frequency band in arbitrary units and in absolute values, high-frequency band in arbitrary units and in absolute values, standard deviation of the instantaneous beat-to-beat variability (standard deviation 1), long-term standard deviation of continuous RR intervals (standard deviation 2), and Stress Index. We used Student's t-test for comparisons and Spearman's coefficient for correlations. RESULTS: We observe insignificant values in the differences between the groups. Disability and self-efficacy were correlated with heart rate variability only in patients with chronic neck pain, whereas catastrophizing and kinesiophobia showed greater correlations with heart rate variability in patients with chronic low back pain. CONCLUSIONS: Autonomic dysfunction of individuals with chronic neck pain, when compared to patients with chronic low back pain, does present insignificant differences.

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Supplementation of Kaempferia parviflora Extract Enhances Physical Fitness and Modulates Parameters of Heart Rate Variability in Adolescent Student-Athletes: A Randomized, Double-Blind, Placebo-Controlled Clinical Study

Cited by 7 publications

References 43 publications

DAF-16 and SKN-1 mediate Anti-aging and Neuroprotective efficacies of “thai ginseng” Kaempferia parviflora Rhizome extract in Caenorhabditis elegans

DAF-16 and SKN-1 mediate Anti-aging and Neuroprotective efficacies of “thai ginseng” Kaempferia parviflora Rhizome extract in Caenorhabditis elegans

Beetroot Juice Produces Changes in Heart Rate Variability and Reduces Internal Load during Resistance Training in Men: A Randomized Double-Blind Crossover

Comparison of the autonomic nervous system dysfunction between different chronic spine disorders: neck pain versus low back pain

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