Supplementation of <i>Emblica Officinalis</i> (Amla) Extract Reduces Oxidative Stress in Uremic Patients

Chen, Tung-Sheng; Liou, Show-Yih; Chang, Yen-Lin

doi:10.1142/s0192415x09006680

Cited by 40 publications

(21 citation statements)

References 21 publications

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“…Recent studies try to use antioxidants as protective remedies against CI-AKI have yielded conflicting results [34-36]. Antioxidant effect of PE was demonstrated in vitro and vivo studies by increased the concentration of antioxidant enzymes SOD and CAT and decreased MDA in lipid peroxidation [37-39]. The present study demonstrated that antioxidant effect of PE extract could decrease MDA in both plasma and renal tissues.…”

Section: Discussionmentioning

confidence: 49%

Antioxidant effect of Phyllanthus emblica extract prevents contrast-induced acute kidney injury

Tasanarong

Kongkham

Itharat

2014

BMC Complement Altern Med

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BackgroundContrast-induced acute kidney injury (CI-AKI) occurs after the administration of intravenous iodinated contrast agents. Oxidative stress has been proposed as one of the most important mechanisms in the pathogenesis of CI-AKI. The objective of this study was to investigate the antioxidant effect of the extract from Phyllanthus emblica (PE) in preventing CI-AKI.MethodsMale Sprague Dawley rats were subjected into eight groups, were given water (control) or PE extract (125 or 250 or 500 mg/kg/day) for 5 days before the induction of CI-AKI. Renal function and oxidative stress markers; malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD) and catalase (CAT) activity were determined in plasma and renal tissue. Kidney sections were performed for histopathological examination.ResultsIn the contrast media (CM) group, increases in blood urea nitrogen and serum creatinine were demonstrated which correlated with severity of tubular necrosis, peritubular capillary congestion and interstitial edema. Moreover, an increase in MDA and a decrease in TAC SOD and CAT activity in CM group were significantly changed when compared with the control (P < 0.05). In contrast, CI-AKI-induced rats administrated with PE extract 250 and 500 mg/kg/day significantly preserved renal function and attenuated the severity of pathological damage (P < 0.05) as well as significantly lower MDA and higher TAC, SOD and CAT than the CM group (P < 0.05).ConclusionsThis study demonstrated the protective role of PE extract against CI-AKI.

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Section: Discussionmentioning

confidence: 49%

Antioxidant effect of Phyllanthus emblica extract prevents contrast-induced acute kidney injury

Tasanarong

Kongkham

Itharat

2014

BMC Complement Altern Med

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“…In the last study (Santus et al, 2005), the same extract was consumed also by nine healthy controls, but a significant decrease in isoprostanes excretion was found only in smokers with baseline levels higher than controls. Finally, in the study by Chen et al (2009), a decrease of plasma isoprostanes was reported after four months of consumption of Emblica officinalis (Amla or Indian goosberry) extract.…”

Section: Intervention Studies With Galenic Preparations Containing Plmentioning

confidence: 89%

“…No effect on isoprostanes and NEAC urinary levels was described by Stewart et al (2002) after a three-week supplementation with fruit and vegetable gummy supplements in 20 children. The last study reporting NEAC measurement was published by Chen et al (2009), where an increase of plasma NEAC was found together with a reduction of plasma isoprostanes after supplementation with Amla extract.…”

Section: Intervention Studies With Galenic Preparations Containing Plmentioning

confidence: 99%

Antioxidant Modulation of F2-Isoprostanes in Humans: A Systematic Review

Petrosino¹,

Serafini²

2014

Critical Reviews in Food Science and Nutrition

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F2-isoprostanes are a biomarker of lipid peroxidation, and their measurement has emerged as a reliable approach to assess oxidative stress. However, dietary intervention studies in humans have provided contrasting results following supplementation with antioxidant-rich foods or supplements. In this paper, we have systematically reviewed the evidence about the effect of supplementation with antioxidant-rich foods and galenic antioxidants on isoprostanes levels in humans. Moreover, the association with nonenzymatic antioxidant capacity (NEAC), a biomarker of endogenous antioxidant status, has also been investigated.MEDLINE database was searched using the terms "(isoprostane * OR isoP OR iso-PGF OR epi-PGF) AND (intervention * OR consumption * OR administration * OR supplementation * )," with limits activated "humans" and "English." Abstracts and full texts were screened, from which were selected human intervention studies reporting isoprostanes measurement in biological fluids. The total of the studies carried out with antioxidant-rich foods and antioxidant galenic supplements was 113, reporting 154 interventions. Results suggest that dietary antioxidants modulate successfully the levels of isoprostanes in less than 45% of the interventions. A correspondence between the effect on isoprostane and NEAC has been evidenced, and this correspondence suggests the importance of measuring different biomarkers to obtain a better outline of the redox events following supplementation.

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“…Earlier studies used dosages of 800 mg of EGCG=day 18 and 450 mg of AE=day for a human study. 19 We used dosages of 300 mg of EGCG and 300 mg of AE=day in this study. The plasma antioxidant=oxidative status was investigated in uremic patients with diabetes after they received 1:1 EGCG= AE for 3 months.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Epigallocatechin-3-Gallate and Amla (Emblica officinalis) Extract for the Treatment of Diabetic-Uremic Patients

Chen

Liou²,

et al. 2011

Journal of Medicinal Food

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Uremic patients with diabetes suffer from high levels of oxidative stress due to regular hemodialysis therapy (neutrophil activation induced by hemo-incompatibility between the hemodialyser and blood) and complications associated with diabetes. Several plasma biomarkers were screened in 13 uremic diabetic patients after receiving the mixture of (-)-epigallocatechin gallate (EGCG), a major component of green tea extract, and Amla extract (AE), from Emblica officinalis, the Indian gooseberry, for 3 months. We found that oral administration of a 1:1 mixture of EGCG and AE for 3 months significantly improved antioxidant defense as well as diabetic and atherogenic indices in uremic patients with diabetes. Furthermore, no significant changes in hepatic function, renal function, or inflammatory responses were observed. These results suggest that a 1:1 combination of EGCG and AE is a safe and effective treatment for uremic patients with diabetes.

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Supplementation of Emblica Officinalis (Amla) Extract Reduces Oxidative Stress in Uremic Patients

Cited by 40 publications

References 21 publications

Antioxidant effect of Phyllanthus emblica extract prevents contrast-induced acute kidney injury

Antioxidant effect of Phyllanthus emblica extract prevents contrast-induced acute kidney injury

Antioxidant Modulation of F2-Isoprostanes in Humans: A Systematic Review

Efficacy of Epigallocatechin-3-Gallate and Amla (Emblica officinalis) Extract for the Treatment of Diabetic-Uremic Patients

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