Supplementation of<i>Bacillus amyloliquefaciens</i>AS385 culture broth powder containing 1-deoxynojirimycin in a high-fat diet altered the gene expressions related to lipid metabolism and insulin signaling in mice epididymal white adipose tissue

Parida, Isabella Supardi; Takasu, Soo; Ito, Junya; Ikeda, Ryoichi; Yamagishi, Kazumasa; Kimura, Toshiyuki; Eitsuka, Takahiro; Nakagawa, Kiyotaka

doi:10.1039/d0fo00271b

Cited by 10 publications

(8 citation statements)

References 66 publications

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“…16−18 However, the working mechanisms behind these effects are still unclear, although some reports have linked the absorption and organ uptake of DNJ and fagomine with their functional properties. 17,19 Considering this, detailed information about the pharmacokinetic profile of aza-sugars is necessary to accurately determine the working mechanism of DNJ, fagomine, and GAL-DNJ.…”

Section: Resultsmentioning

confidence: 99%

“…Aza-sugars in mulberry leaves (e.g., DNJ and fagomine) have been widely known for their antihyperglycemic activity . More recent studies have started to put emphasis on other beneficial features of DNJ and fagomine, such as antilipid accumulation, antihypertension, and anticancer properties. − However, the working mechanisms behind these effects are still unclear, although some reports have linked the absorption and organ uptake of DNJ and fagomine with their functional properties. , Considering this, detailed information about the pharmacokinetic profile of aza-sugars is necessary to accurately determine the working mechanism of DNJ, fagomine, and GAL-DNJ.…”

Section: Resultsmentioning

confidence: 99%

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Intestinal Absorption and Tissue Distribution of Aza-Sugars from Mulberry Leaves and Evaluation of Their Transport by Sugar Transporters

Takasu

Parida

Ito

et al. 2020

J. Agric. Food Chem.

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Mulberry leaves are rich in aza-sugars, particularly 1-deoxynojirimycin (DNJ), fagomine, and 2-O-α-d-galactopyranosyl-1-deoxynojirimycin (GAL-DNJ), which have antidiabetes and antiobesity properties. To help us understand the mechanisms of action of aza-sugars, pharmacokinetic studies are necessary. Therefore, in this study, we evaluated and compared the absorption and organ distribution of these aza-sugars in rats. Following oral intake, DNJ exhibited the highest plasma concentration followed by fagomine and GAL-DNJ. Meanwhile, similar amounts of DNJ and fagomine were present in organs, while GAL-DNJ was hardly detected, suggesting the diversity in absorption and distribution characteristics of these aza-sugars. We then investigated the role of the sodium-glucose cotransporter and the glucose transporter (GLUT) in the transport of aza-sugars and found that both are involved in DNJ transport, while transport of fagomine is solely facilitated by the GLUT. These findings provide insight into the bioavailability and bioactive mechanisms of these aza-sugars.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Intestinal Absorption and Tissue Distribution of Aza-Sugars from Mulberry Leaves and Evaluation of Their Transport by Sugar Transporters

Takasu

Parida

Ito

et al. 2020

J. Agric. Food Chem.

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“…Another report claimed morphine brain accumulation of ~ 0.01% from oral dose of 9 mg/kg 41 . Considering a brain-transportable natural compound, 1-deoxynojirimycin showed an appropriate accumulation of ~ 1.2 pmol/mg in the brain of Sprague–Dawley rats after oral administration at 40 μmol or 6.5 mg/kg 42 , 43 . Conversely, despite the low accumulation or poor uptake ratio of 0.0037% of Tyr-[ 13 C 5 , 15 N]Pro in the mouse brain at 10 mg/kg observed in the present oral administration study, we have previously shown significant improvement in impaired memory in amyloid β-induced AD mice following daily Tyr-Pro intake (100 mg/kg, twice a day) for 16 days 18 suggesting that low Tyr-Pro accumulation, even at 100 mg/kg, would be effective when one expects a preventive effect against the onset of AD.…”

Section: Discussionmentioning

confidence: 99%

A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration

Cheng,

Tanaka,

Yoshino

et al. 2023

Sci Rep

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The transport and accumulation of orally administered functional food-derived peptides in the brain was not fully explored. Thus, in the present study, we aimed to provide critical evidence regarding brain accumulation of a memory-improving soy dipeptide, Tyr-Pro, following oral administration. Stable isotope-labeled Tyr-Pro (Tyr-[13C5,15N]Pro) was orally administered to male ICR mice at 10 or 100 mg/kg. Surprisingly, the intact labeled Tyr-Pro exhibited maximal plasma and brain levels 15 min after administration (plasma: area under the curve [AUC0–120 min], 1331 ± 267 pmol·min/mL-plasma; brain: AUC0–120 min of 0.34 ± 0.11 pmol·min/mg-dry brain, at 10 mg/kg). In addition, we detected labeled Tyr-Pro in the brain parenchyma, indicating a validated blood–brain-barrier (BBB) transportability. Moreover, we confirmed the preferable accumulation of Tyr-Pro in the hypothalamus, hippocampus, and cortex with > 0.02 pmol/mg-tissue. In conclusion, we provided the first evidence that orally administered Tyr-Pro at 10 mg/kg directly entered the blood circulation with an absorption ratio of 0.15%, of which 2.5% of Tyr-Pro was transported from the plasma to the mouse brain parenchyma.

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“…1-Deoxynojirimycin (1-DNJ), a polyhydroxylated piperidine alkaloid [ 35 ], is a potent α-glucosidase inhibitor with unique bioactivities, such as anti-inflammatory, antioxidant, and anticancer [ 57 , 58 , 59 ]. 1-DNJ exhibited anti-hyperglycemic activity through regulating the expression of proteins related to glucose transport systems, glycolysis, and gluconeogenesis enzymes [ 60 , 61 , 62 ]. In addition, 1-DNJ also possesses anti-microbial properties.…”

Section: Bioactive Compounds In the Mulberry And Their Bioactivitiesmentioning

confidence: 99%

Protective Application of Morus and Its Extracts in Animal Production

Wang

Gao

Sun

et al. 2022

Animals

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Different components of the mulberry tree (fruits, leaves, twigs, and roots) are rich in active compounds, and have been reported to possess potent beneficial properties, including antioxidative, anti-inflammatory, antimicrobial, anticancer, anti-allergenic, antihypertensive, and neuroprotective. The mulberry and its extracts can effectively improve the growth performance and fitness of animals. They not only possess the properties of being safe and purely natural, but also they are not prone to drug resistance. According to the literature, the supplemental level of the mulberry and its extracts in animal diets varies with different species, physiological status, age, and the purpose of the addition. It has been observed that the mulberry and its extracts enhanced the growth performance, the quality of animal products (meat, egg, and milk), the antioxidant and the anti-inflammatory responses of animals. Furthermore, the mulberry and its extracts have antibacterial properties and can effectively moderate the relative abundance of the microbial populations in the rumen and intestines, thus improving the immunity function of animals and reducing the enteric methane (CH4) production in ruminants. Furthermore, the mulberry and its extracts have the potential to depurate tissues of heavy metals. Collectively, this review summarizes the nutrients, active compounds, and biological functions of mulberry tree products, as well as the application in livestock production with an aim to provide a reference for the utilization of the mulberry and its extracts in animal production.

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Supplementation ofBacillus amyloliquefaciensAS385 culture broth powder containing 1-deoxynojirimycin in a high-fat diet altered the gene expressions related to lipid metabolism and insulin signaling in mice epididymal white adipose tissue

Abstract: Supplementation of Bacillus amyloliquefaciens AS385 culture broth powder in high-fat diet restored adiposity, glucose tolerance and insulin sensitivity in mice.

Cited by 10 publications

References 66 publications

Intestinal Absorption and Tissue Distribution of Aza-Sugars from Mulberry Leaves and Evaluation of Their Transport by Sugar Transporters

Intestinal Absorption and Tissue Distribution of Aza-Sugars from Mulberry Leaves and Evaluation of Their Transport by Sugar Transporters

A memory-improving dipeptide, Tyr-Pro, can reach the mouse brain after oral administration

Protective Application of Morus and Its Extracts in Animal Production

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