Supplementation of docosahexaenoic acid (DHA), vitamin D3 and uridine in combination with six weeks of cognitive and motor training in prepubescent children: a pilot study

Hansen, Solvejg L; Ritterband-Rosenbaum, Anina; Voigt, Camilla B.; Hellgren, Lars; Sørensen, Ann‐Dorit Moltke; Jacobsen, Charlotte; Greve, Line; Jørgensen, Katrine D.; Bilde, Peder E.; Kiens, Bente; Nielsen, Jens Bo

doi:10.1186/s40795-017-0155-1

Cited by 1 publication

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“…It is probably these mechanisms which are responsible for the positive effect of DHA supplementation on learning and memory, which has been documented in rodents [38,59,60]. Human studies have shown mixed results [42,61,62,63,64]. The low intake of n-3 fatty acids in children with severe CP was observed despite n-3 fatty acid supplements in many of the feeding tube products.…”

Section: Discussionmentioning

confidence: 99%

“…The low intake of n-3 fatty acids in children with severe CP identifies a need for an increased intake of n3-rich products or dietary supplementations such as DHA supplementation. DHA supplementation has previously been shown to increase circulating DHA in healthy preschool children [42], and might therefore be one recommended solution in order to ensure sufficient levels in children with severe CP.…”

Section: Discussionmentioning

confidence: 99%

“…Physical fitness level was evaluated in CP I–II and TD by measurements of maximal oxygen uptake (VO2 max) during an incremental treadmill running test to exhaustion, as previously described [42]. In brief, the protocol started with 1 min of running at an individual maximal running speed of 9–11.5 km/h on a slope of 0% followed by a stepwise 1% incline every 1 min until exhaustion.…”

Section: Methodsmentioning

confidence: 99%

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Suboptimal Nutrition and Low Physical Activity Are Observed Together with Reduced Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration in Children with Severe Cerebral Palsy (CP)

et al. 2019

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Brain-derived neurotrophic factor (BDNF) is a mediator of exercise and nutrition-induced neural plasticity. In children with cerebral palsy (CP), neuromuscular deficits and mobility impairment have a negative impact on their physical activity level and nutritional status, but whether these children have reduced BDNF concentrations is unknown. Therefore, the aim of the present study was to investigate the plasma BDNF concentration, nutritional status, and physical activity level in children with mild to severe CP. Blood sampling, dietary registration, and questionnaires were completed for children with mild CP (gross motor function classification system (GMFCS) I–II, n = 31, age 10.6 ± 0.6 years), severe CP (GMFCS IV–V, n = 14, age 10.9 ± 1.1 years) and typically developed (TD) children (n = 22, age 10.9 ± 0.6 years). Children with severe CP had ~40% lower plasma BDNF concentration than TD children (p < 0.05). Furthermore, children with severe CP had lower daily physical activity level than TD children (p < 0.01), and a daily intake of energy, n-3 fatty acids, and dietary fibers that was only ~50% of TD (p > 0.001). Reduced plasma BDNF concentrations were observed in children with severe CP. This may be of significance for optimal neural growth and plasticity. This was observed together with low physical activity levels and a suboptimal intake of energy, n-3 fatty acids, and dietary fibers.

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