Supplementation of Cerelac baby food with yeast–probiotic cocktail strains induces high potential for aflatoxin detoxification both <i>in vitro</i> and <i>in vivo</i> in mother and baby albino rats

Hamad, Gamal M.; Taha, Tarek H.; Hafez, Elsayed E.; Ali, S. H.; El-Sohaimy, Sobhy A.

doi:10.1002/jsfa.8518

Cited by 17 publications

(8 citation statements)

References 30 publications

(67 reference statements)

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“…The hexane layer was removed, and samples were subjected to HPLC analysis. The samples were analyzed for the quantification of aflatoxins by HPLC according to the method of Hamad et al (2018) and Scaglioni and Badiale‐Furlong (2016).…”

Section: Methodsmentioning

confidence: 99%

Quality Assessment, Functional Potentials, and Safety Evaluation of Stored Egyptian Honey as an Environmental Pollution Bioindicator

Hamad

Hafez

Abdelmotilib

et al. 2020

Enviro Toxic and Chemistry

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Egyptian honeys are distinguished by their variety, properties, and therapeutic applications. The aim of the present study was to evaluate the quality and the functional and safety characteristics of Egyptian honey as a sensitive environmental bioindicator collected from 9 different locations in Egypt that were exposed to various air pollution sources, either stationary, mobile, or area sources, and stored for 6 mo at ambient temperature (22 ± 2°C) compared with Codex Alimentarius international standards. Physicochemical properties, sugar profile via high performance liquid chromatography, functional potentials (antioxidant and antimicrobial), and safety parameters (microbiological quality, aflatoxins, and heavy metal pollutants) were assessed. The results revealed that honey obtained from Shabshir Hessa, El Gharbia Governorate (GSH-1), showed the best quality with the highest monosaccharide and phenolic and flavonoid content (73.07%, 363.07, and 15.33 mg/g, respectively) and clear of biotic and abiotic contaminants, reflecting good hygienic, environmental conditions and apiarian practices. The other 8 honey samples reflected inferior quality in physicochemical parameters either of low monosaccharide content (40.46-50.25%), high hydroxymethylfurfural (HMF) values as in Borg El-Arab Industrial Zone, Alexandria Governorate (BAI-9), and Nubaria Desert Road, Alexandria Governorate (NDR-4; 50.83 and 48.25 mg/kg), or of high acidity as in Agricultural Road, El Gharbia Governorate (GAR-3), and NDR-4 (74.72 and 68.47 mEq/kg) attributable to contaminated locations (fermentations) or thermal treatment (HMF). Furthermore, safety assessment revealed that coliform counts exceeded 2.5 log 10 cfu/g in 6 samples-Chemicals Company, Kafr El Zayyat Governorate (KZC-2); GAR-3; NDR-4; Mansoura Fertilizer Talkha Company, Daqahlia Governorate (MFT-5); Gharbaniyat Cement Company, Beheira Governorate; and BAI-9-and the highest counts of yeast and molds in Abees Ceramic Company, Alexandria Governorate (3.72 log 10 cfu/g), which was reflected in its total aflatoxins (679.83 μg/kg). Samples MFT-5; GAR-3; Kafr El-Sheikh Petroleum Company, Kafr El-Sheikh Governorate; and KZC-2 exceeded the lead permissible limit (0.75, 0.61, 0.57, and 0.51 mg/kg, respectively) as a result of inferior hygienic quality and the negative effects of environmental pollutants. The results ring alarm bells about how we should take substantial steps toward stringent standards for quality control practices of honey production operations.

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Section: Methodsmentioning

confidence: 99%

Quality Assessment, Functional Potentials, and Safety Evaluation of Stored Egyptian Honey as an Environmental Pollution Bioindicator

Hamad

Hafez

Abdelmotilib

et al. 2020

Enviro Toxic and Chemistry

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“…Many dangerous bacteria are suppressed in a low-pH environment; hence Bifidobacterium ’s capacity to raise the acidity of the gut likely plays a role in its probiotic benefits [ 81 ]. Studies have indicated the binding or physical absorption of toxins by Bifidobacterium [ 42 , 55 , 70 ] ( Table 2 ). A research paper discovered that having B. lactis HN019 in the diet can boost natural immunity.…”

Section: Biodetoxification Activity Of Probioticsmentioning

confidence: 99%

Biodetoxification and Protective Properties of Probiotics

2022

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Probiotic consumption is recognized as being generally safe and correlates with multiple and valuable health benefits. However, the mechanism by which it helps detoxify the body and its anti-carcinogenic and antimutagenic potential is less discussed. A widely known fact is that globalization and mass food production/cultivation make it impossible to keep all possible risks under control. Scientists associate the multitude of diseases in the days when we live with these risks that threaten the population’s safety in terms of food. This review aims to explore whether the use of probiotics may be a safe, economically viable, and versatile tool in biodetoxification despite the numerous risks associated with food and the limited possibility to evaluate the contaminants. Based on scientific data, this paper focuses on the aspects mentioned above and demonstrates the probiotics’ possible risks, as well as their anti-carcinogenic and antimutagenic potential. After reviewing the probiotic capacity to react with pathogens, fungi infection, mycotoxins, acrylamide toxicity, benzopyrene, and heavy metals, we can conclude that the specific probiotic strain and probiotic combinations bring significant health outcomes. Furthermore, the biodetoxification maximization process can be performed using probiotic-bioactive compound association.

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“…These comprise a considerable number of compounds, some of which are precursors of well-known and regulated mycotoxins, whose negative effects on human health are currently inconclusive (Stanciu et al, 2017;Spanic et al, 2020). A risk of consumption of emerging mycotoxins by humans is suspected because their toxic effects have been demonstrated in laboratory animals or in vitro studies (Ali et al, 2018;Hamad et al, 2018). Emerging mycotoxins such as enniatins, beauvericin, moniliformin, fusaproliferin, fusaric acid, culmorin, butenolide (produced by Fusarium), sterigmatocystin, and emodin (produced by Aspergillus), as well as alternariol, alternariol monomethyl ether, tenuazonic acid, and altertoxins (produced by Alternaria) have been found in foods and feeds, thus compromising safety (Panasiuk et al, 2019;Agriopoulou et al, 2020).…”

Section: Mycotoxins Most Relevant To Human Healthmentioning

confidence: 99%

“…Inoculated LAB have been demonstrated to prevent the growth of Fusarium on barley during the brewing process (Peyer et al, 2017). The use of a mixture of yeasts (Kluyveromyces lactis and Saccharomyces cerevisiae) and LAB (Lactobacillus acidophilus and Bifidobacterium bifidum) inoculated in baby foods made from wheat has been shown to reduce the concentration of aflatoxins B 1 , B 2 , G 1 , and G 2 by as much as 93% (Hamad et al, 2018). The application of yeasts has been demonstrated to reduce the concentrations of mycotoxins in products by binding DON, OTA, zearalenone, and FB 1 on cell membranes (Agriopoulou et al, 2020).…”

Section: Treatments To Reduce Mycotoxin Concentrations In Foodsmentioning

confidence: 99%

Mycotoxins in foods, from the field to the plate: a review

Barajas‐Ramírez¹,

Moncada-Abaunza²,

Gómez-Espinoza³

2021

IFRJ

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Mycotoxins are secondary metabolites produced by some fungal species, mainly from the genera Alternaria, Aspergillus, Fusarium, and Penicillium. Mycotoxins can be found in raw materials and processed foods. High intake of mycotoxins in short time periods will generate outbreaks of mycotoxicosis distinguished by physical discomfort or even death. Chronic consumption of mycotoxins can cause several important illnesses. Due to the substantial health risk of mycotoxin intake, several organisations have recommended the maximum allowable limits in foods. Since differences in the values suggested across organisations affect the risk of populations ingesting these compounds, the criteria must be unified. Mycotoxins are generally highly thermostable. Operations commonly applied during food processing such as frying and roasting have variable effects in reducing the mycotoxin content. The use of probiotics to transform mycotoxins into minor toxic compounds is a promising alternative reduction measure. The complete elimination of mycotoxins in foods appears practically impossible. Therefore, good agronomic practices are essential to avoid the growth of mycotoxin-producing fungi in raw materials. Global climate change is a relevant issue due to the changes in rainfall, humidity, and temperature patterns worldwide could stimulate the growth of fungi in broader regions, thus increasing the risk of mycotoxin presence in foods and subsequent consumption. Therefore, increasing research and development in innovative methods for the elimination or reduction of mycotoxins in foods is essential.

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Supplementation of Cerelac baby food with yeast–probiotic cocktail strains induces high potential for aflatoxin detoxification both in vitro and in vivo in mother and baby albino rats

Abstract: A mixture of yeast-probiotic coctile was successful in reducing the level of AF in rat sera and diminished the deleterious effect of AFs on animal health. © 2017 Society of Chemical Industry.

Cited by 17 publications

References 30 publications

Quality Assessment, Functional Potentials, and Safety Evaluation of Stored Egyptian Honey as an Environmental Pollution Bioindicator

Quality Assessment, Functional Potentials, and Safety Evaluation of Stored Egyptian Honey as an Environmental Pollution Bioindicator

Biodetoxification and Protective Properties of Probiotics

Mycotoxins in foods, from the field to the plate: a review

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