Supplementation of amino acids and organic acids prevents the increase in blood pressure induced by high salt in Dahl salt-sensitive rats

Abstract

High-salt (HS) diet leads to metabolic disorders in Dahl salt-sensitive (SS) rats, which promotes the development of hypertension. According to the changes in the metabolites of SS rats, a set...

Revealing the Pathogenesis of Salt-Sensitive Hypertension in Dahl Salt-Sensitive Rats through Integrated Multi-Omics Analysis

“…For instance, saltinduced accumulation of amino acids (L-cysteine, DL -isoleucine, L-glutamic acid, and N-methylalanine) and organic acids (fumaric acid, pyruvic acid, and L-lactic acid) were effectively reversed by curcumin, which is consistent with the concept that changes in renal oxygen metabolism lead to alterations in metabolic intermediaries, which in turn are involved in BP regulation [6]. Flux discontinuities in the citrate cycle, enhanced PPP and glycolysis are closely related to perturbation in amino acids such as taurine and hypotaurine metabolism, and glutathione metabolism in this study, which will interrupt the redox balance and result in salt-sensitive hypertension [15]. As expected, curcumin significantly attenuated salt-induced oxidative stress in renal tissues by increasing antioxidant activity (Figure 10).…”

“…For instance, metabolomic biomarkers of hypertension, such as L-tyrosine, L-valine, fumaric acid, creatinine, and L-lactic acid [57], were reduced by curcumin in the liver tissues. In contrast, glycine and hypotaurine, which could lower BP [15], increased significantly in HSCUR rats compared to HS rats. Moreover, evidence supports that curcumin can regulate host metabolism by modulating gut microbial composition.…”

“…The Dahl salt-sensitive rat strain SS/JrHsd/McwiCrl (denoted SS) is typically used as a salt-sensitive hypertensive rat model [14]. Our previous study suggested that HSD feeding changes the metabolic pathways in the kidneys of SS rats, including amino acid metabolism and carbohydrate metabolism [15]. However, it needs to be confirmed whether HSD feeding would induce similar changes in hepatic metabolism.…”