Supplementary Table S1; Supplementary Figures S1-S2 from P7170: A Novel Molecule with Unique Profile of mTORC1/C2 and Activin Receptor-like Kinase 1 Inhibition Leading to Antitumor and Antiangiogenic Activity

Abstract

<p>Supplementary Table S1; Supplementary Figures S1-S2. Supplementary Table 1. A) IC50 value of P7170 in pan-PI3K. B) Kinase inhibition data (ProQinase) of P7170 at 250 nM and 1. 5 μM.C) Kinase inhibition profile (KINOMEscan; 320 kinases) of P7170. D) IC50 values of selected kinases on treatment with P7170. Supplementary Figure S1. The growth response curves on treatment of P7170 on various patient-derived cancer cell lines. Supplementary Figure S2. P7170 induces autophagy in A2780 (A) and HCT116 (B) cells.</p>