Supplementary Studies on the Multiplication of Escherichia Coli O-111 B4 in the Intestinal Tract of Adult Volunteers and Its Relation to Manifestation of Coli Enteritis

Abstract

In our previous reports1) on an experiment in feeding adult volunteers with Escherichia coli O-111 B4 by means of the Miller Abbott double lumen tube,

Acute undifferentiated human diarrhea in the tropics

“…Although alterations in coliform biotypes have been observed in a variety of naturally occurring and experimental diarrheal diseases (29)(30)(31)(32)(33)(34), it is still possible that certain microorganisms from the feces of our patients with a mixed flora might be pathogenic. For example, the experiments of Koya, Kosakai, and Fukasawa (35) with implantation of EEC in healthy volunteers showed that subjects who developed only mild diarrhea had a mixed intestinal microflora consisting of the pathogenic E. coli as well as other elements of the coliform flora. Those with severe diarrhea had a flora predominantly of the implanted EEC strain.…”

Jejunal Microbial Flora of Southern Indian Infants in Health and With Acute Gastroenteritis

“…In adults, Koya, Kosakai and Fukasawa (1954) gave EEC by mouth to healthy volunteers and showed that in subjects who developed mild diarrhoea a mixed jejunal microflora occurred, consisting of the EEC strain administered as well as other coliforms, while in those who developed severe diarrhoea the strain of EEC that had been administered predominated. Gorbach et al (1971) also found that patients with a " mixed flora" in the upper small intestine had a relatively mild disease.…”

New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development.

“…No animal models existed to demonstrate pathogenicity and no other recognized virulence properties were identifiable by which to differentiate the diarrhea-associated strains from other E. coli. Accordingly, in the early 1950s several groups carried out challenge studies in humans involving oral feeding of EPEC serotypes (95,195,220,221,297,393). Four groups of investigators reported feeding studies in humans with EPEC strains of serogroup 0111; these are summarized in Table 8.…”