Abstract:<p>Supplementary Figure S1. Chemical structures of selected tankyrase inhibitors. Supplementary Figure S2. OM-153 specifically inhibits TNKS1/2 and WNT/β-catenin signaling. Supplementary Figure S3. OM-153 specifically inhibits cell growth of an APC-mutated colon carcinoma cell line. Supplementary Figure S4. OM-153 shows an anti-proliferative effect in human cancer cell lines. Supplementary Figure S5. OM-153 inhibits WNT/β-catenin, YAP and MYC signaling in human cancer cell lines. Supplementary Figure S6.… Show more
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