Supplementary figures from β-Catenin Is a Candidate Therapeutic Target for Myeloid Neoplasms with del(5q)

Abstract

<p>Supplemental Figure 1. Indo suppresses beta-catenin expression. (A) Luciferase reporter assay of beta-catenin transcription activity. (B) beta-catenin expression in MDSL and UoC-M1 cells after Indo treatment for 72 hours. *, P <0.05. Supplemental Figure 2. Indo induces apoptosis of human MDSL, UoCM1 and KG1 cell lines with a del(5q). The histograms of the flow cytometric analysis of apoptosis of leukemia cell lines treated with 100μM Indo. Supplemental Figure 3. beta-catenin suppression induces apoptosis of human MDSL, UoCM1 and KG1 cell lines with a del(5q). The histograms of the flow cytometric analysis of apoptosis of leukemia cell lines expressing PLKO or PLKO-beta-catenin shRNAs.</p>