Supplementary figures from PI3K Positively Regulates YAP and TAZ in Mammary Tumorigenesis Through Multiple Signaling Pathways

Abstract

<p>Figure. 1 PIK3CB positively regulates TAZ. S-Figure. 2 Quantitation of subcellular localization of YAP and TAZ. S-Figure 3. PDK1 regulates LATS-YAP/TAZ through its kinase activity. S-Figure 4. No direct regulations between LATS and AKT. S-Fig. 5 AKT1 positively regulates YAP expression which is involved in YAP-LATS negative feedback. S-Figure 6. A-B. YAP and TAZ were knocked out through CRISPR system in MCF10A-PIK3CB or PIK3CA-H1047R cells</p>