Supplementary Figures 1-6; Supplementary Methods and Materials; Supplementary References from TAp63-Regulated miRNAs Suppress Cutaneous Squamous Cell Carcinoma through Inhibition of a Network of Cell-Cycle Genes

Abstract

<p>This file contains the following: Supplementary Figure 1: Representative H&E staining and immunohistochemistry for keratin 5 of a metastasis in the lung of a tumor-bearing TAp63-/- mouse. Supplementary Figure 2: TAp63-deficient tumors exhibit deregulated mRNA and miRNA expression. Supplementary Figure 3: TAp63-regulated miR-30c-2* and miR-497-5p suppresses cuSCC through induction of cell death and cell cycle arrest. Supplementary Figure 4: Identification of miRNA targets through the use of TMT-LC-MS/MS. Supplementary Figure 5: Inhibition of miR-30c-2-3p and miR-497-5p targets affects cuSCC cell proliferation and survival. Supplementary Figure 6: AURKA is a viable therapeutic target in cuSCC. Supplementary Methods and Materials. Supplementary References.</p>