Supplementary Figures 1 - 5 from ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia

Abstract

<p>Supplementary Figure 1 shows NMR and biochemical data in support of LEDGF nucleosome binding specificity. Supplementary Figure 2 shows chromatin IP data indicating requirement for LEDGF in MLL target gene localization. Supplementary Figure 3 shows global and gene-specific chromatin localization of ASH1L. Supplementary Figure 4 shows quantitation of differentiation and apoptosis following ASH1L knockdown. Supplementary Figure 5 shows that over-expression of KDM2A interferes with MLL-mediated leukemic transformation phenotypes.</p>