Supplementary Figure S2 from The TMPRSS2–ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition

Abstract

<p>TMPRSS2/ERG expression reduces S964 MDC-1 but not S25 53BP1 IRIFs. Confocal immunostaining for phosphorylation of S25-53BP1 (A) and S964-MDC1 (B) in PC3 and TMPRSS2-ERG-expressing cells at the indicated times after IR. Right panel indicates the quantified foci/nucleus. Error bars represent SD (n=3).</p>