Supplemental Vitamins and Minerals for CVD Prevention and Treatment

Jenkins, David; Spence, J. David; Giovannucci, Edward; Kim, Young–In; Josse, Robert G.; Vieth, Reinhold; Mejía, Sonia Blanco; Viguiliouk, Effie; Nishi, Stephanie K.; Sahye-Pudaruth, Sandhya; Paquette, Melanie; Patel, Darshna; Mitchell, Sandy; Kavanagh, Meaghan; Tsirakis, Tom; Bachiri, Lina; Maran, Atherai; Umatheva, Narmada; McKay, Taylor; Trinidad, Gelaine; Bernstein, Daniel; Chowdhury, Awad; Correa-Betanzo, Julieta; Principe, Gabriella Del; Hajizadeh, Anisa; Jayaraman, Rohit; Jenkins, Amy; Jenkins, Wendy; Kalaichandran, Ruben; Kirupaharan, Geithayini; Manisekaran, Preveena; Qutta, Tina; Shahid, Ramsha; Silver, Alexis; Villegas, Cleo; White, Jessica; Kendall, Cyril W.C.; Pichika, Sathish Chandra; Sievenpiper, John L.

doi:10.1016/j.jacc.2018.04.020

Cited by 207 publications

(152 citation statements)

References 81 publications

Supporting

Mentioning

128

Contrasting

Unclassified

Order By: Relevance

“…Improved diet quality is associated with reduced all‐cause mortality. whereas multivitamin and multimineral supplements may not improve life expectancy.…”

Section: Discussionmentioning

confidence: 99%

The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta‐review of meta‐analyses of randomized controlled trials

et al. 2019

View full text Add to dashboard Cite

The role of nutrition in mental health is becoming increasingly acknowledged. Along with dietary intake, nutrition can also be obtained from “nutrient supplements”, such as polyunsaturated fatty acids (PUFAs), vitamins, minerals, antioxidants, amino acids and pre/probiotic supplements. Recently, a large number of meta‐analyses have emerged examining nutrient supplements in the treatment of mental disorders. To produce a meta‐review of this top‐tier evidence, we identified, synthesized and appraised all meta‐analyses of randomized controlled trials (RCTs) reporting on the efficacy and safety of nutrient supplements in common and severe mental disorders. Our systematic search identified 33 meta‐analyses of placebo‐controlled RCTs, with primary analyses including outcome data from 10,951 individuals. The strongest evidence was found for PUFAs (particularly as eicosapentaenoic acid) as an adjunctive treatment for depression. More nascent evidence suggested that PUFAs may also be beneficial for attention‐deficit/hyperactivity disorder, whereas there was no evidence for schizophrenia. Folate‐based supplements were widely researched as adjunctive treatments for depression and schizophrenia, with positive effects from RCTs of high‐dose methylfolate in major depressive disorder. There was emergent evidence for N‐acetylcysteine as a useful adjunctive treatment in mood disorders and schizophrenia. All nutrient supplements had good safety profiles, with no evidence of serious adverse effects or contraindications with psychiatric medications. In conclusion, clinicians should be informed of the nutrient supplements with established efficacy for certain conditions (such as eicosapentaenoic acid in depression), but also made aware of those currently lacking evidentiary support. Future research should aim to determine which individuals may benefit most from evidence‐based supplements, to further elucidate the underlying mechanisms.

show abstract

“…Improved diet quality is associated with reduced all‐cause mortality. whereas multivitamin and multimineral supplements may not improve life expectancy.…”

Section: Discussionmentioning

confidence: 99%

The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta‐review of meta‐analyses of randomized controlled trials

et al. 2019

View full text Add to dashboard Cite

show abstract

“…In a prospective study with Korean men, the authors found that higher dietary intake levels of vitamin B6 were associated with a reduced CVD risk [165]. Vitamin B3 might increase all-cause mortality, which was probably associated with its adverse effects on glycemic response [166,167].…”

Section: Vitamin B-complex and Microbiotamentioning

confidence: 99%

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

et al. 2020

View full text Add to dashboard Cite

The importance of gut microbiota in health and disease is being highlighted by numerous research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke, is responsible for about 50% of all cardiovascular deaths. Recently, gut dysbiosis has been identified as a remarkable factor to be considered in the pathogenesis of cardiovascular diseases (CVDs). In this review, we briefly discuss how external factors such as dietary and physical activity habits influence host-microbiota and atherogenesis, the potential mechanisms of the influence of gut microbiota in host blood pressure and the alterations in the prevalence of those bacterial genera affecting vascular tone and the development of hypertension. We will also be examining the microbiota as a therapeutic target in the prevention of CVDs and the beneficial mechanisms of probiotic administration related to cardiovascular risks. All these new insights might lead to novel analysis and CVD therapeutics based on the microbiota.

show abstract

“…The most popular mechanism of action proposed for (poly)phenols is based on their antioxidant properties. However, provision of antioxidants actually increases cancer risk (Jenkins et al, ), and the exact role of oxidative stress (now called redox code; Jones & Sies, ; and never fully elucidated in humans) in cancer aetiology is, to date, still elusive. Conceivably, modulation of the redox code by (poly)phenols (including OOPC) might play some roles in cancer and progression of cancer stem cells, as well as adjunct therapy (Ritter & Greten, ).…”

Section: Pharmacological and Nutraceutical Properties Of Htmentioning

confidence: 99%

Section: Chemopreventionmentioning

confidence: 99%

An overview of the pharmacology of olive oil and its active ingredients

Visioli

Dávalos

Hazas

et al. 2019

British J Pharmacology

View full text Add to dashboard Cite

In addition to providing sensory stimuli, usually taste, smell and sight, olive oil contains a range of minor components, mostly phenolic in nature. These components are endowed with pharmacological or pharma‐nutritional properties that are the subject of active research worldwide. Based on our more than 25 years of experience in this field, we critically focus on what we believe are the most pharmacologically prominent actions of the constituents of olive oil. Most of the effects are due to the phenolic compounds in extra virgin olive oil, such as hydroxytyrosol and oleocanthal (which are often mis‐categorized as in vivo antioxidants) and concern the cardiovascular system. Other potentially beneficial activities are still to be investigated in depth. We conclude that—in the context of a proper diet that includes high‐quality products—the use of high‐quality olive oil contributes to achieving and sustaining overall health. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

show abstract

Supplemental Vitamins and Minerals for CVD Prevention and Treatment

Cited by 207 publications

References 81 publications

The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta‐review of meta‐analyses of randomized controlled trials

The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta‐review of meta‐analyses of randomized controlled trials

The Gut Microbiota and Its Implication in the Development of Atherosclerosis and Related Cardiovascular Diseases

An overview of the pharmacology of olive oil and its active ingredients

Contact Info

Product

Resources

About