Supplemental selenium source on gut health: insights on fecal microbiome and fermentation products of growing puppies

Abstract

Selenium is an essential trace element that can modulate the gut microbiome with an impact on host health. The present study aimed to evaluate the effects of organic (selenium-enriched yeast) vs inorganic (sodium selenite) selenium source on fecal end-fermentation products and gut microbiome of puppies from 20 to 52 weeks of age. Alpha and beta diversity of the gut bacterial community were affected by age but not by gender or selenium source. The relative abundance of taxa was differently affected by age, and the DNA concentration of all selected bacterial groups increased with age, although total volatile fatty acids (VFA), acetate, propionate, caproate, and lactate concentrations decreased. Organic selenium was associated with a higher concentration of total VFA, propionate, and butyrate, a higher number of DNA copies of Lactobacillus, and a trend to lower DNA copies of Escherichia coli. Effects on fecal microbiome during growth differed with selenium source. Females had higher fecal end-fermentation products related to protein degradation, whereas males had higher DNA concentration of Bifidobacterium. Organic selenium might be beneficial over inorganic for dog food supplementation due to the positive modulation of the gut microbiome observed in puppies.

Selenium Yeast Dietary Supplement Affects Rumen Bacterial Population Dynamics and Fermentation Parameters of Tibetan Sheep (Ovis aries) in Alpine Meadow

“…In this study, the bacteria diversity index of Tibetan sheep was not found to vary significantly between the groups receiving SeY supplement and the CK group, suggesting that Se-supplemented diets do not affect the diversity of rumen bacterial community in Tibetan sheep. A study on growing Beagle puppies reported that the αdiversity index of the gut bacterial community is not affected by the Se source (sodium selenite or SeY) (Pereira et al, 2020), which is consistent with our results. Dietary changes play an important role in altering the composition of rumen microbial communities.…”

Antibiotic-induced disruption of the microbiome exacerbates chemotherapy-induced diarrhoea and can be mitigated with autologous faecal microbiota transplantation

“…Muribaculaceae (S24-7) is a typical rodent bacterial family belonging to the Bacteroidetes phylum already documented to regulate FMT efficacy in rodents [49]. It is recognised to increase in abundance after prebiotic intervention with vitamin B2 18 and selenium [50], both of which have documented benefits in the prevention of mucosal injury caused by chemotherapy [18,51].…”

Associations between Urinary and Dietary Selenium and Blood Metabolic Parameters in a Healthy Northern Italy Population

“…The specificity of both nutritional and toxic properties of selenium critically depends on their chemical species [ 16 , 17 , 72 , 73 ], and this may also be true for the adverse effects on metabolic parameters. Finally, the potential mechanisms underpinning the adverse metabolic effects of selenium should be investigated in a more in-depth fashion, focusing on the possible influence of selenium species on redox status [ 74 , 75 , 76 ], protein integrity [ 77 ] and the microbiome—a less investigated but potentially interesting lead due to its connection with metabolic and chronic diseases [ 78 , 79 ].…”