Supplemental Figures S1-5 from Pharmacologically Increasing Mdm2 Inhibits DNA Repair and Cooperates with Genotoxic Agents to Kill p53-Inactivated Ovarian Cancer Cells

Abstract

<p>Supplemental Figures S1-5. Figure S1. Nutlin inhibits γH2AX foci formation and prolongs resolution. Figure S2. Inhibition of pS/TQ foci formation and resolution by Nutlin. Figure S3. Nutlin inhibits γH2AX foci formation and resolution in ovarian cancer cells. Figure S4. Nutlin cooperates with genotoxic agents in p53-inactivated ovarian cancer cells. Figure S5. Nutlin and DNA damaging drugs combine to kill ovarian cancer cells that harbor mutant p53.</p>