Supplemental Figures and Table from mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors

Abstract

<p>Supplementary Figure S1. MPNSTs are sensitive to combined HDAC and mTOR inhibtion; Supplementary Figure S2. Change in animal weight while on combiniation treatment; Supplementary Figure S3. A) 90-8TL cells were treated with Nexturastat A at concentration indicated, with (black) or without (white) 100nM sapanisertib; Supplementary Figure S4. Combined HDAC and mTOR inhibition increases reactive oxygen species in MPNSTs;Supplementary Figure S5. TXNIP is required for combination induced MPNST cell death;Supplementary Table S1. Differentially expressed gene sets in MPNSTs treated with HDAC and mTOR inhibitors</p>