Supplemental dietary choline during development exerts antidepressant-like effects in adult female rats

Glenn, Melissa J.; Adams, Raven S.; McClurg, Lauren

doi:10.1016/j.brainres.2012.01.018

Cited by 32 publications

(40 citation statements)

References 73 publications

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“…Finally, in normally developing female rats (i.e. not prenatally stressed) prenatal choline supplementation exerts antidepressant-like effects in adulthood [33]. Thus, perinatal choline supplementation enhances many brain and behavioral parameters that are typically compromised by prenatal stress, suggesting perinatal choline may be capable of counteracting the effects of prenatal stress on adult anxiety-related behavior.…”

Section: Introductionmentioning

confidence: 99%

Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors

Schulz

Pearson

Gasparrini

et al. 2014

Behavioural Brain Research

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Brain cholinergic dysfunction is associated with neuropsychiatric illnesses such as depression, anxiety, and schizophrenia. Maternal stress exposure is associated with these same illnesses in adult offspring, yet the relationship between prenatal stress and brain cholinergic function is largely unexplored. Thus, using a rodent model, the current study implemented an intervention aimed at buffering the potential effects of prenatal stress on the developing brain cholinergic system. Specifically, control and stressed dams were fed choline-supplemented or control chow during pregnancy and lactation, and the anxiety-related behaviors of adult offspring were assessed in the open field, elevated zero maze and social interaction tests. In the open field test, choline supplementation significantly increased center investigation in both stressed and nonstressed female offspring, suggesting that choline-supplementation decreases female anxiety-related behavior irrespective of prenatal stress exposure. In the elevated zero maze, prenatal stress increased anxiety-related behaviors of female offspring fed a control diet (normal choline levels). However, prenatal stress failed to increase anxiety-related behaviors in female offspring receiving supplemental choline during gestation and lactation, suggesting that dietary choline supplementation ameliorated the effects of prenatal stress on anxiety-related behaviors. For male rats, neither prenatal stress nor diet impacted anxiety-related behaviors in the open field or elevated zero maze. In contrast, perinatal choline supplementation mitigated prenatal stress-induced social behavioral deficits in males, whereas neither prenatal stress nor choline supplementation influenced female social behaviors. Taken together, these data suggest that perinatal choline supplementation ameliorates the sex-specific effects of prenatal stress.

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Section: Introductionmentioning

confidence: 99%

Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors

Schulz

Pearson

Gasparrini

et al. 2014

Behavioural Brain Research

View full text Add to dashboard Cite

show abstract

“…However, in a large population-based study, choline concentrations were negatively associated with anxiety symptoms, but not depression [90]. Further, rats fed a choline supplemented perinatal diet, out-performed control rats in in an open-water learning maze and forced swim test [91]. Hence, choline supplementation during development may prevent stress and depression.…”

Section: Cholinementioning

confidence: 97%

The Effects of Vitamin B in Depression

Mikkelsen¹,

Stojanovska²,

Apostolopoulos

2016

CMC

128

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Abstract:Vitamins are dietary components which are necessary for life. They play a major role in health and their deficiency may be linked to symptoms of psychiatric disorders. B vitamins are required for proper functioning of the methylation cycle, monoamine oxidase production, DNA synthesis and the repair and maintenance of phospholipids. Vitamin B deficiency could influence memory function, cognitive impairment and dementia. In particular, vitamins B1, B3, B6, B9 and B12 are essential for neuronal function and deficiencies have been linked to depression. We discuss the causes of depression and the neurochemical pathways in depression. In particular, we provide evidence that vitamin B contributes to the complexity of depressive symptoms.

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“…2C, D), may reflect elevated levels of BDNF within the hippocampal formation. BDNF, which has been shown to increase in response to maternal choline supplementation in normal rodents [117], increases survival of newly proliferated neurons [118, 119] and plays an important role in spatial learning and memory [120] (see Iluta and Cuello article in this issue).…”

Section: Effects Of Mcs On Spatial Cognition Hippocampal Neurogenesimentioning

confidence: 99%

Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease

Strupp

Powers²,

Velázquez³

et al. 2015

CAR

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Although Down syndrome (DS) can be diagnosed prenatally, currently there are no effective treatments to lessen the intellectual disability (ID) which is a hallmark of this disorder. Furthermore, starting as early as the third decade of life, DS individuals exhibit the neuropathological hallmarks of Alzheimer’s disease (AD) with subsequent dementia, adding substantial emotional and financial burden to their families and society at large. A potential therapeutic strategy emerging from the study of trisomic mouse models of DS is to supplement the maternal diet with additional choline during pregnancy and lactation. Studies demonstrate that maternal choline supplementation (MCS) markedly improves spatial cognition and attentional function, as well as normalizes adult hippocampal neurogenesis and offers protection to basal forebrain cholinergic neurons (BFCNs) in the Ts65Dn mouse model of DS. These effects on neurogenesis and BFCNs correlate significantly with spatial cognition, suggesting functional relationships. In this review, we highlight some of these provocative findings, which suggest that supplementing the maternal diet with additional choline may serve as an effective and safe prenatal strategy for improving cognitive, affective, and neural functioning in DS. In light of growing evidence that all pregnancies would benefit from increased maternal choline intake, this type of recommendation could be given to all pregnant women, thereby providing a very early intervention for DS fetuses, and include babies born to mothers unaware that they are carrying a DS fetus.

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Supplemental dietary choline during development exerts antidepressant-like effects in adult female rats

Cited by 32 publications

References 73 publications

Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors

Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors

The Effects of Vitamin B in Depression

Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease

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