Suplementos en gestación: últimas recomendaciones

García, Rosa María Martínez; Ortega, Ana; Lombán, Beatriz Navia

doi:10.20960/nh.336

Cited by 9 publications

(8 citation statements)

References 12 publications

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“…[ 30 , 31 ] Since both iron deficiency and iron excess result in free radical mitochondrial damage, iron supplementation is now only advisable for pregnant women with proven iron-deficiency anaemia. [ 30 , 32 ] In this study, we found a positive correlation between superoxide concentration and ferritin concentration at 25 weeks of pregnancy, which confirms that an excess in iron supplementation can cause harm by augmenting the amount of OS. This finding has previously been described in another pregnancy complication, gestational diabetes mellitus.…”

Section: Discussionsupporting

confidence: 73%

Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function

et al. 2018

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BackgroundDuring normal pregnancy, placental oxidative stress (OS) is present during all three trimesters and is necessary to obtain normal cell function. However, if OS reaches a certain level, pregnancy complications might arise. In preeclampsia (PE), a dangerous pregnancy specific hypertensive disorder, OS induced in the ischemic placenta causes a systemic inflammatory response and activates maternal endothelial cells. In this study, we aimed to quantify superoxide concentrations (as a measure of systemic OS) using electron paramagnetic resonance (EPR) and correlate them to markers of systemic inflammation, iron status and vascular function.MethodsFifty-nine women with a healthy pregnancy (HP), 10 non-pregnant controls (NP) and 28 PE patients (32±3.3weeks) were included. During HP, blood samples for superoxide, neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV) and iron status were taken at 10, 25 and 39 weeks. Vascular measurements for arterial stiffness (carotid-femoral pulse wave velocity (CF-PWV), augmentation index (AIx), augmentation Pressure (AP)) and microvascular endothelial function (reactive hyperemia index (RHI)) were performed at 35 weeks. In PE, all measurements were performed at diagnosis. CMH (1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine) was used as spin probe for EPR, since the formed CM radical corresponds to the amount of superoxide.ResultsSuperoxide concentration remains stable during pregnancy (p = 0.92), but is significantly higher compared to the NP controls (p<0.0001). At 25 weeks, there is a significant positive correlation between superoxide and ferritin concentration. (p = 0.04) In PE, superoxide, systemic inflammation and iron status are much higher compared to HP (all p<0.001). During HP, superoxide concentrations correlate significantly with arterial stiffness (all p<0.04), while in PE superoxide is significantly correlated to microvascular endothelial function (p = 0.03).ConclusionsDuring HP there is an increased but stable oxidative environment, which is correlated to ferritin concentration. If superoxide levels increase, there is an augmentation in arterial stiffness. In PE pregnancies, systemic inflammation and superoxide concentrations are higher and result in a deterioration of endothelial function. Together, these findings support the hypothesis that vascular function is directly linked to the amount of OS and that measurement of OS in combination with vascular function tests might be used in the prediction of PE.

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Section: Discussionsupporting

confidence: 73%

Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function

et al. 2018

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“…Calcium absorption during pregnancy increases up to 40% and supplementation is only recommended in pregnant women with an intake <600 mg/day, if there is a risk of preeclampsia, or in adolescent pregnancies [ 1 ]. With regard to this food source, overall, this study shows a good result since more than half of the pregnant women complied with the recommendations by including dairy products in their daily diets.…”

Section: Resultsmentioning

confidence: 99%

“…Certain micronutrients must be supplemented before and during pregnancy since most women often do not meet the recommended requirements [ 29 ]. Supplementation with 400 μg of folic acid is recommended 1 month before conception for at least the first 2–3 months of pregnancy and in risk situations during the nine months [ 1 ]. In this study, the results were positive since there was higher consumption of folic acid by women with CV risk.…”

Section: Discussionmentioning

confidence: 99%

“…Pregnancy is a physiological stage effecting changes in nutritional requirements, thereby increasing energy and nutritional needs [ 1 ]. Maternal nutrition before conception and during pregnancy is considered one of the most influential factors affecting the proper growth of the fetus and the possible future development of chronic diseases during in adult life [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Mediterranean Dietary Pattern and Cardiovascular Risk in Pregnant Women

Morales-Suárez-Varela

Peraita-Costa

Marín

et al. 2023

Life

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Nutrition during pregnancy is one of the most important factors that determine the health of a mother and the proper development of her fetus. The main objective of this study was to analyze the association between adherence to a Mediterranean dietary (MedDiet) pattern and cardiovascular (CV) risk factors in pregnant women. Accordingly, we carried out an observational, population-based study using data from pregnant women present in a hospital during the entire course of their pregnancy. Adherence to the MedDiet was assessed using the MedDiet score questionnaire. Our study identified that 87.25% (95%CI: 83.48–90.27) of the women had a cardiovascular risk in relation to their dietary intake. Women with diet-related CV risk were more likely to smoke (p = 0.004), weighed more at the beginning of pregnancy, engaged in little physical activity, and had lower adherence to the MedDiet pattern than women without a diet-related CV risk. Dietary analysis showed low consumption of cereals, vegetables, and fish, which failed to satisfy the recommended portions in Spain. Adequate adherence to the MedDiet was found for 54.2% of women who were considered to be without CV risk and 45.8% of women with CV risk. Our data suggest that the MedDiet could be improved in relation to the consumption of cereals, vegetables, and fish during pregnancy in order to reduce CV risk.

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“…Contrary to the current WHO recommendations regarding dietary Fe supplementation in pregnant women at a dose of 30–60 mg daily throughout pregnancy, regardless of the state of Fe saturation in the body [ 81 ], the results presented in the literature on the effects of Fe supplementation in pregnant women demonstrated that it should not be used in women without IDA [ 82 ]. It is emphasized that the health consequences of supplementation strictly depend on the initial state of Fe saturation in the bodies of pregnant women [ 64 , 83 ].…”

Section: Discussionmentioning

confidence: 96%

Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum

et al. 2021

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Oxidative stress (OS) in the foetal and neonatal periods leads to many disorders in newborns and in later life. The nutritional status of pregnant women is considered to be one of the key factors that triggers OS. We investigated the relationship between the concentration of selected mineral elements in the blood of pregnant women and the concentration of 3′nitrotyrosine (3′NT) as a marker of OS in the umbilical cord blood of newborns. The study group consisted of 57 pregnant women and their newborn children. The concentrations of magnesium (Mg), calcium (Ca), iron (Fe), zinc (Zn) and copper (Cu) in maternal serum (MS) were measured by the flame atomic absorption/emission spectrometry (FAAS/FAES) method. The concentration of 3′NT in umbilical cord serum (UCS) of newborns was determined by the ELISA method. A positive correlation between MS Fe and UCS 3′NT in male newborns was shown (rho = 0.392, p = 0.053). Significantly higher UCS 3′NT was demonstrated in newborns, especially males, whose mothers were characterized by MS Fe higher than 400 μg/dL compared to those of mothers with MS Fe up to 300 μg/dL (p < 0.01). Moreover, a negative correlation between the MS Cu and UCS 3′NT in male newborns was observed (rho = −0.509, p = 0.008). Results of the study showed the need to develop strategies to optimize the nutritional status of pregnant women. Implementation of these strategies could contribute to reducing the risk of pre- and neonatal OS and its adverse health effects in the offspring.

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Suplementos en gestación: últimas recomendaciones

Cited by 9 publications

References 12 publications

Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function

Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function

Mediterranean Dietary Pattern and Cardiovascular Risk in Pregnant Women

Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum

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