Supine breast MRI

Siegler, Peter; Holloway, Claire; Causer, Petrina; Thevathasan, Gilbert; Plewes, Donald B.

doi:10.1002/jmri.22605

Cited by 36 publications

(27 citation statements)

References 21 publications

(18 reference statements)

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“…5 recent investigations have demonstrated feasibility [16]. MRI is non-ionizing, unlike CT, and could enable additional imaging throughout the patients treatment in future, to improve accuracy without exposing the patient to further ionising radiation.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Comparison of Magnetic Resonance Imaging and Computed Tomography for Breast Target Volume Delineation in Prone and Supine Positions

Pogson

Delaney

Ahern

et al. 2016

International Journal of Radiation Oncology*Biology*Physics

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Purpose/Objective(s): MRI provides no ionizing radiation dose (allowing inter and intra fraction imaging), improved soft tissue contrast and potentially improved conformity in delineation than CT. This study aimed to determine if T2 weighted magnetic resonance imaging improves seroma cavity (SC) and Whole Breast (WB) inter-observer conformity for radiotherapy purposes compared with the gold standard of CT, both in the prone and supine positions. Results: Imaging modality did not affect inter-observer variation for WB CTVs. Prone WB CTVs were larger in volume and more conformal than Supine CTVs (on both MRI and CT). SC volumes were larger on CT than MRI. SC volumes proved to be comparable in inter-observer conformity in both modalities (VOI of 0.57±0.03 for CT supine, 0.52±0.04 for MR supine, 0.56±0.03 for CT prone and 0.55±0.04 for MR prone) however after registering modalities together the inter-modality variation (DSC of 0.41±0.05 for supine and 0.38±0.04 for prone) was larger than the inter-observer variability for SC despite the location typically remaining constant.Conclusions: MRI inter-observer variation was comparable to CT for the WB CTV and SC delineation, in both prone and supine positions. Whilst the CVS and inter-observer concordance M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 3 was not significantly higher for MRI than CT, the SCs were smaller on MRI, potentially due to clearer SC definition, especially on T2-weighted MR images.

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Comparison of Magnetic Resonance Imaging and Computed Tomography for Breast Target Volume Delineation in Prone and Supine Positions

Pogson

Delaney

Ahern

et al. 2016

International Journal of Radiation Oncology*Biology*Physics

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“…3). Siegler et al [33] showed that supine breast MRI resulted in comparable image quality as regular diagnostic MRI. Positioning on a radiotherapy wedge support may be feasible particularly in wide-bore MRI scanners that are now commercially available.…”

Section: Technical Challenges For the Use Of Mri For Rt Dose Paintingmentioning

confidence: 99%

Functional MRI for radiotherapy dose painting

Heide

Houweling

Groenendaal

et al. 2012

Magnetic Resonance Imaging

139

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Modern radiation therapy techniques are exceptionally flexible in the deposition of radiation dose in a target volume. Complex distributions of dose can be delivered reliably, so that the tumor is exposed to a high dose, whereas nearby healthy structures can be avoided. As a result, an increase in curative dose is no longer invariably associated with an increased level of toxicity. This modern technology can be exploited further by modulating the required dose in space so as to match the variation in radiation sensitivity in the tumor. This approach is called dose painting. For dose painting to be effective, functional imaging techniques are essential to identify regions in a tumor that require a higher dose. Several techniques are available in nuclear medicine and radiology. In recent years, there has been a considerable research effort concerning the integration of magnetic resonance imaging (MRI) into the external radiotherapy workflow motivated by the superior soft tissue contrast as compared to computed tomography. In MRI, diffusion-weighted MRI reflects the cell density of tissue and thus may indicate regions with a higher tumor load. Dynamic contrast-enhanced MRI reflects permeability of the microvasculature and blood flow, correlated to the oxygenation of the tumor. These properties have impact on its radiation sensitivity. New questions must be addressed when these techniques are applied in radiation therapy: scanning in treatment position requires alternative solutions to the standard patient setup in the choice of receive coils compared to a diagnostic department. This standard positioning also facilitates repeated imaging. The geometrical accuracy of MR images is critical for high-precision radiotherapy. In particular, when multiparametric functional data are used for dose painting, quantification of functional parameters at a high spatial resolution becomes important. In this review, we will address these issues and describe clinical developments in MRI-guided dose painting.

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“…The one patient with discomfort and hence motion‐derived artifacts was in her 30 th week of pregnancy, the most advanced pregnancy of the cohort. Therefore, for patients in advanced pregnancy, supine examination using a thoracic coil or supine‐designed breast coil might be a proper alternative, although in this pilot study these were not attempted.…”

Section: Discussionmentioning

confidence: 99%