Superwettable nanodendritic gold substrates for direct miRNA SERS detection

Song, Yongchao; Xu, Tailin; Xu, Li-Ping; Zhang, Xueji

doi:10.1039/c8nr07348a

Cited by 68 publications

(42 citation statements)

References 34 publications

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“…As a result, the detection limit of the ultratrace DNA detection reached 2.3 × 10 −16 m on the microchip. The enhancement strategy using patterned‐wettability substrates can be combined with many other analytical strategies for highly sensitive and ultratrace biosensing and detection, such as SERS [ 35,81 ] and colorimetric detection. [ 82 ]…”

Section: Applicationsmentioning

confidence: 99%

Heterogeneous Wettability Surfaces: Principle, Construction, and Applications

Liu

Zhao

et al. 2020

Small Structures

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Surface wettability plays a vital role in liquid-solid-gas systems and has elicited increasing research interest in numerous fields, including self-cleaning, optics and electronics, sensing and detection, heat management, and microfluidics. [1-5] For example, superhydrophobic surfaces, such as the lotus leaf, show minimized adhesion force to water. Water droplets can freely roll off this type of surface and remove dust, granting the surface with a self-cleaning property. [6,7] By comparison, a water drop placed on a hydrophilic surface forms a liquid puddle, with the solutes in the liquid finally deposited on the surface after drying. This is the fundamental mechanism for various printing and lithography techniques for material deposition. [8-10] However, these uniform surfaces fail to meet the rigorous requirements in complex conditions, such as high-resolution functional material patterning and enrichment for parallel detection. Alternatively, heterogeneous wettability substrates with rationally designed water-repellent and water-loving properties can be utilized to satisfy these fastidious requirements. Different regions on such surfaces have distinct wettability, thus exhibiting excellent capability in precisely regulating the solid-liquid interactions. A representative example is the splendid water manipulation of the desert beetle, Stenocara, using the heterogeneous wettability strategy to collect and transport water for survival in the Namib Desert, which is one of the driest places in the world. The hydrophilic bumps distributed on the hydrophobic back of the beetle can capture fog in the moist morning and condensate it into large water droplets. Then, the hydrophobic region serves as a pathway to guide the water droplets rolling to its mouth. [11] This idea has greatly inspired the design and utilization of heterogeneous wettability for various applications. Generally, the terms "hydrophilic" and "hydrophobic" are used to describe the state of a solid surface when contacting with water. If the water droplet contact angle is larger than 90 , the surface is hydrophobic; otherwise the surface is hydrophilic. However, when relating to dynamic liquid manipulation on solid surfaces, the key factor is the solid-liquid adhesion force instead of the hydrophilicity/hydrophobicity. For example, when a water droplet impacts on a hydrophobic and high-adhesive surface equipped with a hydrophilic and low-adhesive stripe, it can be split into two subdrops, which is direct evidence for the solid-liquid adhesion force dominating the liquid's dynamic behavior. [12] Although in many cases, the solid-liquid adhesion force decreases with enhancement of hydrophobicity, for example, the adhesion force on a superhydrophobic surface is much smaller than that on a hydrophilic surface, there exist exceptions, such as a hydrophilic surface having a smaller adhesion force than a hydrophobic surface. [13] Therefore, in these cases the heterogeneous wettability mainly indicates the nonuniformity in the adhesion force. Levkin and cowork...

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Section: Applicationsmentioning

confidence: 99%

Heterogeneous Wettability Surfaces: Principle, Construction, and Applications

Liu

Zhao

et al. 2020

Small Structures

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“…Meanwhile, 3D functional patterns (calcium phosphate, silver nanoparticles, drugs, and biomolecules) with highly sensitive manners were obtained based on such wettable template, demonstrating SERS as well as antibacterial performance. What is more, miRNA-14 112 and H 2 O 2 113 were detected by these patterned wetting surfaces through SERS.…”

Section: F I G U R E 7 (A B) Fabrication Processes To the Electrochementioning

confidence: 88%

Bioinspired superwetting surfaces for biosensing

Zhu

Huang

Lou

et al. 2020

VIEW

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Inspired by nature, scientists and researchers have studied the wetting behaviors on various creatures and mimicked their structures to fabricate diverse functional superwetting materials. As one kind of emerging application, the bioinspired superwettable surfaces used for biosensing have been aroused wide interests. In this review, we summarized the recent developments of bioinspired superwettable surfaces in the field of biosensing. In the first part, superwettable creatures in nature, namely, superhydrophobic self-cleaning lotus leaf, high-adhesion superhydrophobic rose petal, amphiphobic springtail, patterned wetting desert beetles, slippery pitcher plant, were introduced. In sequence, we successively described the special wetting models of superhydrophobicity, superamphiphobicity, responsive wettability, patterned wettability, and slipperiness. Then, biosensing applications based on the respective patterned wettable, superhydrophobic, responsive wettable, and slippery substrates that were combined with the common detection approaches (colorimetry, fluorescence, surface-enhanced Raman scattering (SERS), electrochemistry) were shown in detailed. At last, an insight of remaining challenges and future development for bioinspired superwetting materials applied in biosensing was provided.

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“…SERS has been developed as another powerful miRNA detection method through highly specific and sensitive biological imaging and sensing due to its distinct advantages of high stability, good specificity, and low background signal. This surface-sensitive technology is based on a phenomenon that Raman scattering is enhanced by molecules adsorbed on the plasmonic metal surface or by plasmonic metal nanostructures due to the strong electromagnetic coupling generated nearby the metal nanoparticles [120,121]. However, relatively low sensitivity and extremely rare electromagnetic hot spots in substrates limit its wide applications [55].…”

Section: Signal Transduction and Readout Elementsmentioning

confidence: 99%

“…However, relatively low sensitivity and extremely rare electromagnetic hot spots in substrates limit its wide applications [55]. Fortunately, the introduction of engineered metallic nanoparticles such as target-triggered CHA-induced core-satellite [55], superwettable nanodendritic gold substrates [121], and nanodendritic gold/graphene [122] addressed these problems in principle due to their abilities to aggregate with strong electromagnetic hot spots and finally improve the detection sensitivity for trace amount of miRNA targets.…”

Section: Signal Transduction and Readout Elementsmentioning

confidence: 99%

Avenues Toward microRNA Detection In Vitro: A Review of Technical Advances and Challenges

Zhu

Tan

et al. 2019

Computational and Structural Biotechnology Journal

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Over the decades, the biological role of microRNAs (miRNAs) in the post-transcriptional regulation of gene expression has been discovered in many cancer types, thus initiating the tremendous expectation of their application as biomarkers in the diagnosis, prognosis, and treatment of cancer. Hence, the development of efficient miRNA detection methods in vitro is in high demand. Extensive efforts have been made based on the intrinsic properties of miRNAs, such as low expression levels, high sequence homology, and short length, to develop novel in vitro miRNA detection methods with high accuracy, low cost, practicality, and multiplexity at point-of-care settings. In this review, we mainly summarized the newly developed in vitro miRNA detection methods classified by three key elements, including biological recognition elements, additional micro-/nano-materials and signal transduction/readout elements, their current challenges and further applications are also discussed.

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Superwettable nanodendritic gold substrates for direct miRNA SERS detection

Abstract: By combining a superwettable interface with a nanodendritic gold structure, we have fabricated a superwettable nanodendritic gold substrate for direct SERS detection of multiple concentrations of miRNAs.

Cited by 68 publications

References 34 publications

Heterogeneous Wettability Surfaces: Principle, Construction, and Applications

Heterogeneous Wettability Surfaces: Principle, Construction, and Applications

Bioinspired superwetting surfaces for biosensing

Avenues Toward microRNA Detection In Vitro: A Review of Technical Advances and Challenges

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