“…Multi-instance learning was originated from Dietterich et al (1997)'s research on drug activity prediction, since that it has been studied by a lot of researchers and many algorithms have been developed, such as Diverse Density (Maron & Lozano-Pérez, 1998) and EM-DD (Zhang & Goldman, 2002), the k-nearest neighbor algorithm Citation-kNN (Wang & Zucker, 2000), decision tree algorithms RELIC (Ruffo, 2000) and ID3-MI (Chevaleyre & Zucker, 2001), rule learning algorithm RIPPER-MI (Chevaleyre & Zucker, 2001), SVM algorithms MI-SVM and mi-SVM (Andrews et al, 2003) and DD-SVM (Chen & Wang, 2004), ensemble algorithms MI-Ensemble (Zhou & Zhang, 2003) and MIBoosting (Xu & Frank, 2004), logistic regression algorithm MI-LR (Ray & Craven, 2005), etc. Many of those algorithms were developed by adapting a single-instance supervised learning algorithm to multiinstance learning through shifting its focus from the discrimination on the instances to the discrimination on the bags (Zhou & Zhang, 2003).…”