Supervised physical exercise improves endothelial function in patients with systemic lupus erythematosus

Abstract

Physical exercise is a useful strategy to improve endothelial function and aerobic capacity without worsening disease activity in SLE patients. TRIAL REGISTRATION; ClinicalTrials.gov (http://www.clinicaltrials.gov), NCT01712529.

Exercise training can attenuate the inflammatory milieu in women with systemic lupus erythematosus

“…Given that antagonists of specific cytokines [e.g., anti-IL-10, (24)] have been considered as potential candidates for the treatment of SLE, further studies should determine whether long-term exercise training can be recommend as an adjuvant anti-inflammatory therapy to SLE patients. Further to the investigation of the effects of the chronic exercise training on inflammation, this study provided evidence that chronic exercise training programs can effectively lead to improvements in a cluster of aerobic conditioning parameters, fatigue scores, and selected domains of quality of life, adding to an increasing body of knowledge showing positive clinical outcomes in exercise-trained SLE patients (10,15,28,41). Therefore, these data pointed out that chronic exercise training can be useful as an adjuvant therapy in the management of the comorbidities associated with SLE.…”

“…cardiac autonomic control, fatigue, and quality of life in both adult and childhood SLE patients (10,15,28,35,41). Notwithstanding, there has been a concern that exercise could induce SLE flare by triggering a proinflammatory response.…”

Exercise as an anti-inflammatory therapy for rheumatic diseases—myokine regulation

“…Unchanged or improved inflammatory markers ■ Unchanged or improved disease activity scores and markers of systemic inflammation (erythrocyte sedimentation rate and C-reactive protein) in response to aerobic, 72 Improved cardiovascular function ■ Improved endothelial function and lipid profile in response to aerobic 80 and aerobic plus resistance exercise programmes, 106 and shown by cross-sectional studies 80,103,104,106 ■ Improved autonomic function in response to aerobic plus resistance exercise programmes in in adult SLE 108 and in response to aerobic exercise programmes in juvenile-onset SLE 82,108 Unchanged or decreased levels of inflammatory markers ■ No changes in disease activity scores or markers of systemic inflammation (erythrocyte sedimentation rate and C-reactive protein) in response to aerobic plus resistance exercise in adult SLE 106,108 and to aerobic exercise programmes in adult [78][79][80][81] and juvenile-onset SLE 81 ■ Unchanged or improved levels of selected proinflammatory and anti-inflammatory cytokines and soluble receptors at rest and after exercise (IL-6, IL-10, IFN-γ, TNF, sTNFR1, sTNFR2) in response to aerobic exercise programmes 78…”

The Effects of 10-Week Aerobic-cognitive Combined Training on Serum Levels of High Sensitivity C-reactive Protein, Anti-cardiolipin antibodies, and Mental Status of Female Patients With Lupus Erythematosus Systemic: A Preliminary Study

“…The anti-inflammatory role of physical activities in SLE disease has also been studied by some researchers [23]. Rheumatologic studies have shown that exercise can have a positive effect on the quality of life of patients with lupus by reducing pain and stiffness of the muscles, as well as reducing the frequency of the recurrence of chronic pain and improving the body performance and cognitive function of the patients.…”