Supervised Machine-Learning Algorithm using Low Data Sets: Flow Chemistry Optimization of the Key Urea Moiety Construction in Larotrectinib
Haripriya Thalla,
Varshini Uma Jayaraman,
Maheshkumar Uppada
et al.
Abstract:Unsymmetrical urea is a ubiquitous moiety in pharmaceuticals,
providing
a linkage between pharmacophores. The assembly of an unsymmetrical
urea bridge in various therapeutic agents can be accomplished through
several approaches. Conventional methods involving hazardous compounds
such as phosgene and isolated isocyanates pose safety concerns; a
safe surrogate of phosgene, namely CDI, is popularly employed for
the construction of both symmetrical and unsymmetrical urea. While
the use of CDI for the small-scale s… Show more
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