Supervised exercise reduces cancer-related fatigue: a systematic review

Abstract

PROSPERO CRD42013005803.

The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis

“…The positive effects generated by the meta-analyses for a range of inflammatory mediators justify investigation into the mechanisms underlying these effects so that exercise training exercise can be more precisely prescribed to optimize the prognosis of people with breast cancer. In the interim, exercise training can be encouraged in people during or after breast cancer treatment: because of its known benefits on the problems that cancer induces in physical fitness, function, fatigue, depression, and quality of life (23,24,32,34,35,(48)(49)(50)(51); because of the favorable trends observed in survival with exercise training (38,39); and now also, given the results of this review, because of its positive effects on inflammatory mediators in the tumor microenvironment.…”

Efectividad del ejercicio físico en la fatiga de pacientes con cáncer durante el tratamiento activo: revisión sistemática y metaanálisis

“…Aunque los efectos del ejercicio de resistencia no han sido descritos claramente por la ASCO 47 , existen pruebas de los posibles efectos en la percepción de fatiga en personas con cán-cer de mama 48,49 . Sin embargo, para entender los posibles mecanismos del beneficio de este tipo de entrenamiento, se requiere de información adicional sobre los efectos de la quimioterapia y la radiación en las células satélite musculares o progenitoras que se activan en respuesta al entrenamiento de fuerza.…”

Moderate-intensity exercise reduces fatigue and improves mobility in cancer survivors: a systematic review and meta-regression

“…6 However, these recommendations may not recognise the specific health needs of cancer survivors. Recent reviews have reported a low number of adverse events in relation to exercise trials, 6,7,[18][19][20] suggesting that exercise is generally safe for cancer survivors. However, in these reviews, there has been variable reporting of the dose of prescribed exercise.…”

“…36 Fatigue is a complex multi-dimensional construct related to reduced physical function and reduced health-related quality of life. 27,37 Recent reviews have concluded that exercise reduces cancerrelated fatigue, 19,[38][39][40] but the optimal dose to achieve this has not been established. It has been suggested that patients undergoing treatment may need to exercise at a lower intensity or for a shorter duration than those who have completed primary treatment.…”