Supersulphides suppress type-I and type-II interferon responses by blocking JAK/STAT signalling in macrophages
Xiaoyan Li,
Touya Toyomoto,
Tianli Zhang
et al.
Abstract:Interferons (IFNs) are cytokines produced and secreted by immune cells when viruses, tumor cells, and so forth, invade the body. Their biological effects are diverse, including antiviral, cell growth-inhibiting, and antitumor effects. The main subclasses of interferons include type-I (e.g., IFN-α and IFN-β) and type-II (IFN-γ), which activate intracellular signals by binding to type-I and type-II IFN receptors, respectively. We have previously shown that when macrophages are treated with supersulfide donors, w… Show more
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