Superstructures from Didodecyldimethylammonium Bromide and Poly(acrylic acid)

Everaars, Marcel D.; Nieuwkerk, A.C.; Denis, Solenne; Marcelis, and Antonius T. M.; Sudhölter, Ernst J. R.

doi:10.1021/la960047r

Cited by 15 publications

(13 citation statements)

References 28 publications

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“…Over the past decade, there has been an increasing interest in the creation of vesicles and it has been found that except from double‐chained compounds, including natural amphiphiles (mainly phospholipids) and synthetic surfactants,1–3 vesicles can also form from single‐chained surfactants under specific conditions 4–10. Recently, it was thought that mixture of polyelectrolyte and oppositely charged surfactant could be a new kind of vesicle‐forming candidate system 11–17. The structure of a polyelectrolyte‐surfactant complex was often regarded as micelle‐like, and the “necklace” model18 was proposed and widely accepted.…”

Section: Introductionmentioning

confidence: 99%

“…However, there are still other kinds of microstructures such as vesicular structure formed in the polyelectrolyte‐surfactant system. In 1996, tissue‐like multivesicular superstructures were found upon heating the insoluble complex of didodecyl dimethyl ammonium bromide and poly(acrylic acid) in water,11 showing the feasibility of vesicle formation in the mixed system of ionic surfactant and oppositely charged polyelectrolyte. However, in this system the function of polymer to vesicle formation is unclear because the cationic surfactant itself has the capability to form vesicles.…”

Section: Introductionmentioning

confidence: 99%

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The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer

Kodach

Bleuming

Musler

et al. 2007

Cancer

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BACKGROUND.Transforming growth factor β (TGFβ) is important in colorectal cancer (CRC) progression. Bone morphogenetic proteins (BMPs), a subgroup within the TGFβ superfamily, recently also have been implicated in CRC, but their precise role in CRC has yet to be investigated.METHODS.The authors used a tissue microarray and immunohistochemistry of BMP receptors and signal transduction elements in adenomas and CRC specimens to elucidate the role of BMP signaling in CRC carcinogenesis.RESULTS.The adenoma specimens expressed all 3 BMP receptors (BMPRs) (BMPR type 1a [BMPR1a], BMPR1b, and BMPR2) and expressed SMAD family member 4 (SMAD4); and 20 of 22 adenomas (90.9%) exhibited active BMP signaling, as determined by nuclear phosphorylated SMAD1,5,8 (pSMAD1,5,8) expression. In contrast, pSMAD1,5,8 nuclear staining was present in 5 CRC specimens (22.7%) but was lost in 17 CRC specimens (77.3%; cancer vs adenoma; P < .0001). The earliest loss of pSMAD1,5,8 nuclear staining was detected in regions of high‐grade dysplasia/carcinoma in situ within adenomas. CRCs showed frequent loss of BMPR2 (P < .0001) and SMAD4 (P < .01) compared with adenomas. Negative expression of BMPR2 was observed more frequently in earlier stage cancers (Dukes stage B) than in advanced cancers (Dukes stage C; P < .05).CONCLUSIONS.Taken together, the current results indicated that loss of BMP signaling correlates tightly with progression of adenomas to cancer and occurs relatively early during cancer progression. Cancer 2008. © 2007 American Cancer Society.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer

Kodach

Bleuming

Musler

et al. 2007

Cancer

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“…[17][18][19][20] Different types of phenomena have also been reported in mixed systems of synthetic polycationnegatively charged liposome, comprising changes in the chain melting temperature and permeability of the bilayer, flip-flop of lipid molecules, and disintegration and fusion of liposomes. 16,[21][22][23] From a phase behavior point of view, the polymervesicle systems may lead to novel and interesting phenomena, such as the formation of gels and networks, 10,11,14,24 with potential practical applications. Thermal gelation has been observed in systems of hydrophobically modified polymer and nonionic surfactant bilayers and associated with cross-linking of the vesicles by the polymer chains.…”

Section: Introductionmentioning

confidence: 99%

Interactions between Catanionic Vesicles and Oppositely Charged PolyelectrolytesPhase Behavior and Phase Structure

et al. 1999

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Structural and phase behavior effects resulting from the addition of a polyelectrolyte to a solution of oppositely charged vesicles are investigated in this work. Two cationic polyelectrolytes derived from hydroxyethylcellulose were used: JR400, a homopolymer, and Quatrisoft LM200, a polymer modified with alkyl side chains. The vesicles are composed of mixed anionic surfactant (sodium dodecyl sulfate) and cationic surfactant (didodecyldimethylammonium bromide), bearing 29 mol % of the cationic amphiphile. The phase behavior for the two mixed polymer-surfactant systems was investigated for polymer concentrations between 0.001 and 3 wt%. Three main regions were found in the two-phase maps, upon polymer addition: (i) a bluish solution phase; (ii) a wide region of phase separation, containing a precipitate and a solution; and (iii) a polymer-rich gel region, forming upon charge reversal of the system. Cryo-TEM imaging of the solution phase shows the formation of faceted vesicles and disklike aggregates, upon addition of JR400. For the LM200 system, besides the formation of faceted vesicles, clusters of vesicles and other bilayer structures are imaged. In the polymer-rich phase of JR400, membrane fragments, disklike aggregates, and vesicles are also found. These bilayer aggregates are likely to be involved with the polymer in highly connected networks, giving rise to the observed bluish gels. Electrostatic interactions, reinforced by hydrophobic interactions in the case of LM200, are the main driving force for the structural transitions observed.

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“…Studies on the interactions between ionic surfactants and oppositely charged polyelectrolytes (8)(9) were often hampered by the formation of precipitates (10)(11)(12)(13). In 1996, Everaars et al (14) showed that tissue-like multivesicular superstructures were found upon heating of the insoluble complex of didodecyldimethylammonium and polyacrylic acid in water, showing the feasibility of vesicle formation in the mixed system of ionic surfactants and oppositely charged polyelectrolytes. However, in this system the function of polymers in vesicle formation is unclear, because the cationic surfactant itself has the capability for vesicle formation.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Vesicle Formation in Aqueous Mixtures of Cationic Surfactants and Partially Hydrolyzed Polyacrylamide

Huang

Zhu

et al. 2001

Journal of Colloid and Interface Science

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Superstructures from Didodecyldimethylammonium Bromide and Poly(acrylic acid)

Cited by 15 publications

References 28 publications

The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer

The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer

Interactions between Catanionic Vesicles and Oppositely Charged PolyelectrolytesPhase Behavior and Phase Structure

Spontaneous Vesicle Formation in Aqueous Mixtures of Cationic Surfactants and Partially Hydrolyzed Polyacrylamide

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