Superstable Magnetic Nanoparticles in Conjugation with Near-Infrared Dye as a Multimodal Theranostic Platform

Zhou, Huige; Hou, Xiaoyang; Liu, Ying; Zhao, Tianming; Shang, Qiuyu; Tang, Jinglong; Liu, Jing; Wang, Yuqing; Wu, Qiuchi; Luo, Zehao; Wang, Hui; Chen, Chunying

doi:10.1021/acsami.5b11308

Cited by 54 publications

(37 citation statements)

References 43 publications

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“…First, IR820 reacted with 6‐aminocaproic acid resulting in the modification with a carboxyl group. The blue product preliminarily proved the successful reaction according to the literature . The chemical structure of IR820COOH was confirmed by 1 H NMR spectrum.…”

Section: Resultsmentioning

confidence: 52%

“…Synthesis of T820 : T820 was synthesized by a two‐step conjugation method. In step 1, carboxylated IR820 (IR820COOH) was synthesized on the basis of the previously reported method with minor modifications . Briefly, 6‐aminocaproic acid (0.1623 g, 1.237 mmol) in anhydrous DMF (2 mL) and triethylamine (180 µL) were added sequentially to the IR820 (0.2595 g, 0.3055 mmol) dissolved in dry DMF (3 mL) at 85 °C, and the resulting solution underwent a stir for 4 h in nitrogen atmosphere.…”

Section: Methodsmentioning

confidence: 99%

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Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

Tian

Jiang

et al. 2018

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triggered by near-infrared (NIR) lightexcited photothermal agents [10] while PDT causes the cell death by photosensitizers generating highly cytotoxic reactive oxygen species (ROS) upon light excitation. [11][12][13] With distinct mechanisms of action, the integration of PTT and PDT into one nanoplatform holds great potential to achieve highly efficient cancer therapy. [14][15][16] However, in such combined therapy, two different excitation wavelengths are usually required for the activation of PTT and PDT, [17][18][19] leading to complicated treatment process and prolonged therapeutic time. Thus, it is highly desirable to design a nanoplatform with single NIR light-induced phototherapy.Although strategies of single-wavelength NIR light-mediated PTT/PDT combination therapy have been reported, photothermal agents commonly used in combined systems are inorganic nanomaterials, like gold nanostructures, [20][21][22] MoS 2 nanosheets, [23] black phosphorus nanosheets, [24] and black titania, [25] which show tedious preparation process, poor degradation, difficult excretion, and potential long-term toxicity. NIR organic dyes, which possess unique advantages of outstanding biodegradability and biocompatibility in contrast with inorganic photothermal agents, will be ideal alternatives. Especially, for new indocyanine green (IR820), a structural analog of indocyanine green (ICG), which has been approved by the Food and Drug Administration (FDA) in clinical use, [26][27][28] holds the suitable fluorescence, strong absorption in NIR region, and efficient light-thermal conversion. [29,30] Additionally, it is more stable and easily modified due to the meso-halogen in its chemical structure. Unfortunately, it differs from organic photodynamic agents in intrinsic excitation wavelength, bringing a great challenge to achieve single NIR laser-induced combinational phototherapy. Moreover, it suffers from short half-life in blood, rapid clearance from the body, and lack of specificity to target tumor area. [31,32] Chlorin e6 (Ce6), an FDA-approved second-generation photosensitizer, [33] is extensively used in PDT on account of its high singlet oxygen generation efficiency, [34] near-infrared light excitation allowing deep tissue penetration, and fluorescence imaging capability. [35,36] Despite these upsides, Ce6 has shortcomings including poor water solubility and nonspecific accumulation in tumor sites, [37] which largely compromise Phototherapy as a promising cancer diagnostic and therapeutic strategy has aroused extensive attention. However, single-wavelength near-infrared (NIR) light-triggered combinational treatment of photothermal therapy (PTT) and photodynamic therapy (PDT) is still a great challenge. Herein, a multifunctional micelle activated by a single-wavelength laser for simultaneous PTT and PDT as well as fluorescence imaging is developed. Briefly, new indocyanine green (IR820) is conjugated to d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) via the linker 6-aminocaproic acid, and then, chlorin e6 (Ce6) is enc...

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Section: Resultsmentioning

confidence: 52%

Section: Methodsmentioning

confidence: 99%

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

Tian

Jiang

et al. 2018

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“…Zhou et al conjugated the IR820 onto the surface of iron oxide nanoparticles with 6-amino hexanoic acid to form IR820-CSQ-Fe conjugates. The IR820-conjugated iron oxide nanoparticles showed an enhanced ability to produce singlet oxygen almost double that of free dyes, which improved its efficiency for PDT, and showed increased T1 and T2 relaxation values (Zhou et al, 2016). In another approach, magnetic and fluorescent lanthanide-doped gadolinium oxide (Gd 2 O 3 ) UCNs with bright upconversion luminescence (UCL) and high longitudinal relaxivity ( r 1 ) were used for simultaneous magnetic resonance imaging (MRI)/UCL dual-modal imaging and PDT.…”

Section: Anticancer Therapeutics and Nanoparticle-based Delivery Agentsmentioning

confidence: 99%

Recent Advances in Nanoparticle-Based Cancer Drug and Gene Delivery

Amreddy

Babu

Muralidharan

et al. 2018

Advances in Cancer Research

226

145

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Effective and safe delivery of anticancer agents is among the major challenges in cancer therapy. The majority of anticancer agents are toxic to normal cells, have poor bioavailability, and lack in vivo stability. Recent advancements in nanotechnology provide safe and efficient drug delivery systems for successful delivery of anticancer agents via nanoparticles. The physicochemical and functional properties of the nanoparticle vary for each of these anticancer agents, including chemotherapeutics, nucleic acid-based therapeutics, small molecule inhibitors, and photodynamic agents. The characteristics of the anticancer agents influence the design and development of nanoparticle carriers. This review focuses on strategies of nanoparticle-based drug delivery for various anticancer agents. Recent advancements in the field are also highlighted, with suitable examples from our own research efforts and from the literature.

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“…Many of these dyes are commercially available and used for fluorescent labeling or analysis. To date, various cyanine dyes have been ascertained with the ability to produce 1 O 2 under NIR excitation, such as, IR780, IR820, and indocyanine green (ICG) . To significantly enhance the efficiency of ROS generation, heavily metal‐bromine substituted cyanine Br 2 ‐IR808 dye and iodinated derivatives of IR783 were also developed as above.…”

Section: Nir‐responsive Pss Based On Direct Nir Absorptionmentioning

confidence: 99%

Recent Progress in Near Infrared Light Triggered Photodynamic Therapy

Deng

Huang

et al. 2017

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267

179

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Nowadays, photodynamic therapy (PDT) is under the research spotlight as an appealing modality for various malignant tumors. Compared with conventional PDT treatment activated by ultraviolet or visible light, near infrared (NIR) light-triggered PDT possessing deeper penetration to lesion area and lower photodamage to normal tissue holds great potential for in vivo deep-seated tumor. In this review, recent research progress related to the exploration of NIR light responsive PDT nanosystems is summarized. To address current obstacles of PDT treatment and facilitate the effective utilization, several innovative strategies are developed and introduced into PDT nanosystems, including the conjugation with targeted moieties, O self-sufficient PDT, dual photosensitizers (PSs)-loaded PDT nanoplatform, and PDT-involved synergistic therapy. Finally, the potential challenges as well as the prospective for further development are also discussed.

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Superstable Magnetic Nanoparticles in Conjugation with Near-Infrared Dye as a Multimodal Theranostic Platform

Cited by 54 publications

References 43 publications

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

Recent Advances in Nanoparticle-Based Cancer Drug and Gene Delivery

Recent Progress in Near Infrared Light Triggered Photodynamic Therapy

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