Supersensitivity to Ethanol in Rabbits Treated with Coprinus atramentarius

Barkman, R; Perman, E

doi:10.1111/j.1600-0773.1963.tb01717.x

Cited by 13 publications

(1 citation statement)

References 4 publications

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“…In rats pretreated with coprine or disulfiram, ethanol caused a pronounced fall in blood-pressure. Similar observations have been made on rabbits pretreated with disulfiram (Perman 1962) and also in rabbits receiving orally suspensions of homogenized carpophores of Coprinus atramentarius (Barkman & Perman 1963). Our results indicate that coprine is the active principle in the suspensions used in these experiments.…”

Section: Discussionsupporting

confidence: 89%

On the Disulfiram‐Like Effect of Coprine, the Pharmacologically Active Principle of Coprinus atramentarius

Carlsson¹,

Henning²,

Lindberg³

et al. 1978

Acta Pharmacologica et Toxicologica

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Coprine or disulfiram was given to rats in various doses at various time intervals before the administration of 2 g/kg ethanol. The ratio acetaldehyde/ethanol in the alveolar air was measured by gas chromatography and was taken as an index of the aldehyde dehydrogenase (ALDH) activity. The activity of dopamine β‐hydroxylase (DBH) was estimated in the same animals by measuring the amount of 14C‐octopamine formed from 14C‐tyramine in the heart. Coprine and disulfiram both caused an increase in the acetylaldehyde/ethanol ratio, coprine being more potent than disulfiram. Disulfiram, but not coprine, reduced the net yield of 14C‐octopamine. In rats pretreated with either coprine or disulfiram, blood‐pressure and heart‐rate were recorded before and after intraperitoneal injections of 0.4 g/kg ethanol. In both cases ethanol caused a marked and rapid fall in blood‐pressure. However, this effect was accompanied by tachycardia only in animals treated with coprine. It is concluded that coprine like disulfiram inhibits ALDH, but only disulfiram causes an additional inhibition of DBH. This difference may account for differences in the cardiovascular response to ethanol

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Section: Discussionsupporting

confidence: 89%

On the Disulfiram‐Like Effect of Coprine, the Pharmacologically Active Principle of Coprinus atramentarius

Carlsson¹,

Henning²,

Lindberg³

et al. 1978

Acta Pharmacologica et Toxicologica

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Poisoning by Coprinus atramentarius

Michelot

1992

Natural Toxins

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The ink cap--Coprinus atramentarius (Bulliard ex Fries) Fries--is responsible for poisoning when ingested with alcohol. The investigation of the "Coprinus syndrome," although a minor poisoning incident, stimulated numerous research programs because the results were expected to yield a novel drug useful during the treatment of alcoholism. This work led to the identification of the active principle--coprine--and to an explanation of its mode of action; nevertheless, detailed toxicology investigations have shown that the mutagenic and gonadotoxic properties of this compound made it unsuitable for therapeutic use. Our current knowledge of the poisoning, the chemistry of the toxin, and its mode of action are here reviewed.

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Cyclopropane Derivatives and their Diverse Biological Activities

Salaün

1999

Topics in Current Chemistry

357

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Supersensitivity to Ethanol in Rabbits Treated with Coprinus atramentarius

Cited by 13 publications

References 4 publications

On the Disulfiram‐Like Effect of Coprine, the Pharmacologically Active Principle of Coprinus atramentarius

On the Disulfiram‐Like Effect of Coprine, the Pharmacologically Active Principle of Coprinus atramentarius

Poisoning by Coprinus atramentarius

Cyclopropane Derivatives and their Diverse Biological Activities

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