Supersensitivity to Catecholamines Following Guanethidine

Gokhale, S. D.; Gulati, O. D.; Kelkar, V. V.

doi:10.1111/j.1476-5381.1967.tb02151.x

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Bearing in mind the probable site of action of these two agents, it is possible that the circular muscle is not as richly innervated as the longitudinal with noradrenergic nerves. Holman & McLean (1967) found that contractions of the longitudinal muscle in sheep mesenteric vein to acetylcholine were abolished by phentolamine and atropine. We found phentolamine did not block the response to acetylcholine which was, however, completely abolished by atropine.…”

Section: Discussionmentioning

confidence: 96%

“…Application of Student's t-test has shown this potentiation of the longitudinal muscle by cocaine to be significantly greater than that of the circular muscle (P < 0.05). Gokhale, Gulati & Kelkar (1967). In five veins pretreated with guanethidine (3 x 1 0 -5~) the responses of both the longitudinal and circular muscle to noradrenaline were potentiated ( Table 2).…”

Section: Cocainementioning

confidence: 90%

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The action of vasoactive drugs on longitudinal and circular muscle of dog mesenteric vein

Hall

O'Connor

1973

Journal of Pharmacy and Pharmacology

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The dog anterior mesenteric vein has outer longitudinal and inner circular muscle layers. The response of the vein to drugs was recorded without disrupting the muscle arrangements by combining constant‐flow perfusion of a segment with isometric recording of longitudinal tension. Noradrenaline and acetylcholine were potent stimulants. Tachyphylaxis developed to histamine, 5‐hydroxytryptamine and angiotensin. Cocaine and guanethidine potentiated the responses to noradrenaline and fluorescent microscopy confirmed the presence of adrenergic nerves in both muscle layers. Isoprenaline partially relaxed the stimulated vein and this action was blocked by propranolol. Evidence was obtained which suggests the existence in the vein of specific receptors for several of the agonists investigated.

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Section: Discussionmentioning

confidence: 96%

Section: Cocainementioning

confidence: 90%

The action of vasoactive drugs on longitudinal and circular muscle of dog mesenteric vein

Hall

O'Connor

1973

Journal of Pharmacy and Pharmacology

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Effect of guanethidine on α-adrenoceptor blocking potency of phentolamine in vitro

Bhavsar

Joshi

Kelkar

et al. 1980

European Journal of Pharmacology

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Guanethidine‐induced Acute Hypersensitivity to Noradrenaline in Anaesthetized Rats

Nielsen

1977

Acta Pharmacologica et Toxicologica

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The changes in mean arterial blood pressure, heart rate and the respective noradrenaline dose‐response curves after guanethidine sulphate (0.25, 1.25, 5, 20, and 40 mg/kg given intravenously) were studied in chloralose‐urethane anaesthetized adult rats. After transient changes a dose‐dependent maximum fall of the blood pressure was observed 15 minutes after the administration of guanethidine. A fall in heart rate was observed after guanethidine sulphate 0.25 mg/kg, whereas 1.25, 5, 20, and 40 mg/kg initially increased the heart rate followed by a decrease to subnormal levels with minimum values 6–24 hours after guanethidine. Normalization of blood pressure and heart rate occurred within 24 hours and 96 hours, respectively. Maximum dose‐dependent enhancement of changes in blood pressure by noradrenaline 0.5 μg/kg was obtained approximately 15 minutes after guanethidine. Following guanethidine 40 mg/kg the response was increased by a factor 2, and normalization occurred within 96 hours. Fifteen minutes after guanethidine, significant changes in the response of the heart rate to noradrenaline 0.5 μg/kg were obtained with guanethidine 1.25, 5, and 20 mg/kg, whereas fully developed hypersensitivity after 20 and 40 mg/kg did not occur until 6–24 hours later. Following guanethidine 40 mg/kg the response was increased by a factor of 3, and normalization was observed after 96 hours. The present investigation has demonstrated different time‐dependent patterns of the effect of guanethidine on blood pressure and heart rate responses to noradrenaline.

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Supersensitivity to Catecholamines Following Guanethidine

Cited by 3 publications

References 19 publications

The action of vasoactive drugs on longitudinal and circular muscle of dog mesenteric vein

The action of vasoactive drugs on longitudinal and circular muscle of dog mesenteric vein

Effect of guanethidine on α-adrenoceptor blocking potency of phentolamine in vitro

Guanethidine‐induced Acute Hypersensitivity to Noradrenaline in Anaesthetized Rats

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