Supersensitive and Tunable Nano-Biosensor for Cancer Detection

Nejad, Hamed Emami; Mir, Ali; Farmani, Ali

doi:10.1109/jsen.2019.2899886

Cited by 95 publications

(17 citation statements)

References 78 publications

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“…et al, 2019a , b ; Keshavarz. et al, 2019a , b ; Tao et al, 2010 ; O'Hara et al, 2008 ; Ghafari et al, 2019 ; Emami Nejad et al, 2019 ; Vafapour, 2019 ; Chen et al, 2011b ; Vafapour and Ghahraloud, 2018 ), detecting ( Keshavarz. et al, 2019a , b ; Park et al, 2014 ; Yan et al, 2019 ; Sadeghzadeh Lari et al, 2020 ) and imaging ( Zhang, 2002 ; Carranza et al, 2015 ; Zhou et al, 2018 ) approaches.…”

Section: Introductionmentioning

confidence: 99%

“…Emami Nejad et al. ( Emami Nejad et al., 2019 ) proposed a supersensitive nano biosensor which demonstrated the enhancement of the capability of measurement and detection of cancer cells by THz sensing technology.…”

Section: Introductionmentioning

confidence: 99%

“…The THz imaging, sensing and detecting approaches, which utilizes the EM radiation spectrum between 0.1 and 10 THz, have been investigated to assess their potential to diagnose cancers by measuring the water content change and cell deformation of malignant tumors ( Globus et al., 2003 ; Pickwell and Wallace, 2006 ; Son, 2009 ; Sy et al., 2010 ; Park et al., 2011 ) or by sensing the nanoparticle probes targeted at cancerous tumors ( Oh et al., 2009 ; Oh et al., 2011 ; Park et asl., 2012 ; Son, 2013 ) and/or by analyzing the spectral responses EM THz wave (such as reflected, transmitted and absorbed spectra) from the sample ( Keshavarz. et al., 2019a , b ; Emami Nejad et al., 2019 ) due to changes in the optical properties of the samples.…”

Section: Introductionmentioning

confidence: 99%

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The potential of terahertz sensing for cancer diagnosis

Vafapour

Keshavarz

Ghahraloud

2020

Heliyon

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The terahertz (THz) region lies between the microwave and infrared regions of the electromagnetic (EM) spectrum such that it is strongly attenuated by water and very sensitive to water content. Here, we numerically present what is to our knowledge the detecting system based on THz reflectance spectral responses data in the diagnosis of in vivo and ex vivo of some cancer's samples such as skin, breast and colon cancer tissue samples. The numerical analysis on the use of semiconductor metamaterial design/device as a complex refractive index (CRI) biosensor have been carried out. We demonstrate the application of terahertz pulse detecting (TPD) in reflection geometry for the study of normal and cancerous biological tissues. THz radiation has very low photon energy and thus it does not pose any ionization hazard for biological tissues. The sensitivity of THz radiation to polar molecules, such as water, makes TPD suitable to study the diseases in human body. By studying the THz pulse shape in the time domain, we have been able to differentiate between diseased and normal tissue for the study of basal cell carcinoma (BCC), breast and colon cancers. These results demonstrate the potential of TPD for the study of skin tissue and its related disorders, both in vivo and ex vivo . Findings of this study demonstrate the potential of TPD to depict breast and colon cancers and both in vivo and ex vivo of skin cancer and encourage further studies to determine the sensitivity and specificity of the technique.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The potential of terahertz sensing for cancer diagnosis

Vafapour

Keshavarz

Ghahraloud

2020

Heliyon

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“…16,17 A metamaterial is artificially designed periodically structures that consist of properties such as negative permeability and permittivity. 18 Graphene-based metamaterial sensor has good control in infrared and terahertz regions. They can be easily nanofabricated by electron beam lithography technique, which makes them cost-effective.…”

Section: Introductionmentioning

confidence: 99%

Encrypted and tunable graphene‐based metasurface refractive index sensor

Parmar

Patel

2021

Micro & Optical Tech Letters

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Encryption is a very essential part to secure data communication in today's world where there is a threat of stealing data. We have proposed a graphene-based metasurface biosensor for sensing and encryption applications. The biosensor is designed to sense the hemoglobin (HT) biomolecules with high sensitivity. The results are analyzed in the form of transmittance and electric field of the proposed graphenebased metasurface biosensor. The graphene layer's chemical potential is varied to achieve the coding of '0' and '1'. This creates one-digit coding. The array of this proposed structure with this coding can be used for encryption applications. The biosensor design is analyzed for four HT concentrations and their sensitivity is compared. Different geometrical parameters are analyzed and their effect is observed for tunability. The response from the design can be useful in future biomedical and data encryption applications.

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“…The most important optical characteristic in cancer is refractive index, which mainly determines the difference between normal and malignant cells [1]. The contrast between the refractive indices of the cancerous and normal cells is the principle of photonic biosensors [2][3][4][5][6][7]. PhCs are artificial optical structures formed by periodic arrays of different materials in one, two, or three dimensions [8,9].…”

Section: Introductionmentioning

confidence: 99%

Optimized Cancer Cells Sensor Based on 1d Photonic Crystal Vertical Slot Structure

Bounaas¹,

Labbani²

2021

PIER C

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This paper reports the investigation of a one-dimensional (1D) photonic crystal (PhC) sensor with improved performance for detecting different categories of cancer cells. The sensing region consists of a vertical slot (VS) introduced inside the periodic Bragg mirror. The structure operating principle is based on the change of the refractive index (RI) of the analyte incorporated in the VS, which leads to the shift in the resonant wavelength peak. The sensing properties have been numerically simulated and analyzed using the transfer matrix method (TMM). The study shows that the optimization process of the structure tends to enhance sensitivity. From the result of the numerical simulation, it is found that the final optimized sensor exhibits the higher sensitivity of 3201 nm/RIU than other similar devices. We believe that the obtained results will be valuable for designing highly sensitive PhC sensors.

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Supersensitive and Tunable Nano-Biosensor for Cancer Detection

Cited by 95 publications

References 78 publications

The potential of terahertz sensing for cancer diagnosis

The potential of terahertz sensing for cancer diagnosis

Encrypted and tunable graphene‐based metasurface refractive index sensor

Optimized Cancer Cells Sensor Based on 1d Photonic Crystal Vertical Slot Structure

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