Superselective cisplatin (CDDP)-carboplatin (CBDCA) combined infusion for head and neck cancers

Imai, Shigeki; Kajihara, Yasumasa; Munemori, Osamu; Kamei, Tsuyoshi; Mori, Toshihiro; Handa, Toru; Akisada, Ken; Orita, Yozo

doi:10.1016/0720-048x(95)00692-j

Cited by 40 publications

(13 citation statements)

References 19 publications

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“…Previous reports have described the complications associated with intra-arterial chemotherapy for cancers of the head and neck. [2][3][4] The local toxicity of the chemotherapy agent includes mucositis, dermatitis, skin necrosis, and peripheral and cranial nerve palsies. When the tumor was not enhanced on cone-beam CT, which occurred in 2 of 43 arteries, our interventional radiologists did not perform the superselective intra-arterial chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Recent advances in the therapeutic techniques of interventional radiology, including the development of some types of microcatheters, now enable us to perform superselective arterial infusion to head and neck structures. [1][2][3][4] Because conventional digital subtraction angiography (DSA) provides only 2D projections of the vascular anatomy, however, the identification of the tumor feeding artery is occasionally difficult due to the presence of a complex anatomy or multiple feeding arteries. In addition, staining of head and neck tumors is not always observed on DSA.…”

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confidence: 99%

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A Cone-Beam Volume CT Using a 3D Angiography System with a Flat Panel Detector of Direct Conversion Type: Usefulness for Superselective Intra-arterial Chemotherapy for Head and Neck Tumors

Kakeda¹,

Korogi²,

Miyaguni³

et al. 2007

American Journal of Neuroradiology

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

A Cone-Beam Volume CT Using a 3D Angiography System with a Flat Panel Detector of Direct Conversion Type: Usefulness for Superselective Intra-arterial Chemotherapy for Head and Neck Tumors

Kakeda¹,

Korogi²,

Miyaguni³

et al. 2007

American Journal of Neuroradiology

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“…In Japan, Imai et al (30) and Korogi et al (31) introduced superselective IA infusion using the Seldinger's techniques for head and neck cancer. A microcatheter was placed in the target arteries, selected according to the location of the tumour, via the femoral artery.…”

Section: Superselective Ia Infusionmentioning

confidence: 99%

Intra-arterial chemoradiotherapy for head and neck cancer

Homma¹,

Onimaru²,

Matsuura³

et al. 2015

Jpn. J. Clin. Oncol.

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Intra-arterial chemotherapy has been used to treat localized malignant neoplasms in patients with head and neck cancer for over 50 years as the head and neck region is particularly well suited to regional chemotherapy. Early intra-arterial chemotherapy did not prove its efficacy. In addition, the additional complications associated with establishing and maintaining arterial access have further dampened enthusiasm for this approach. Subsequent significant advances in vascular radiology techniques and the development of new devices, such as fluoroscopy units and angiographic catheters, have made possible safe, accurate and repeated superselective intra-arterial chemotherapy. Intra-arterial infusion of high-dose cisplatin with systemic neutralization by intravenous sodium thiosulfate (RADPLAT) is a theoretically attractive approach to the treatment of advanced head and neck cancer. However, a Dutch trial comparing intra-arterial and intravenous chemoradiotherapy for advanced head and neck cancer showed that RADPLAT was not superior to intravenous chemoradiotherapy. Therefore, further investigation of RADPLAT, including the refinement of the indications for its application, is needed.

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“…Recent advances in the angiographic technique have enabled intra-arterial administration of chemotherapeutic agents under fluoroscopic guidance directly through microcatheters to selectively saturate the targeted primary tumour (Robbins et al, 1992;Imai et al, 1995;Korogi et al, 1995). Encouraging results, including high tumour response rates and good local and regional control, have been noted with targeted intra-arterial chemotherapy and concomitant radiation therapy for advanced head and neck cancer (Robbins et al, 1997;Oya and Ikemura, 1999).…”

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confidence: 99%

AUC of Calvert's formula in targeted intra-arterial carboplatin chemoradiotherapy for cancer of the oral cavity

et al. 2004

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We investigated whether intra-arterial administration of carboplatin using Calvert's formula is useful for avoiding thrombocytopenia in targeted chemoradiotherapy in patients with squamous cell cancer of the oral cavity and oropharynx. Carboplatin was infused intraarterially under digital subtraction angiography in 28 patients. In the first group of patients, the dose of carboplatin was calculated according to the body surface area (BS group). In the second group, the dose was calculated using Calvert's formula (AUC group). The value for AUC (area under concentration vs time curve; mg ml À1 min À1 ) in the formula was set at 4.5. All patients received concurrent radiotherapy (30 Gy) and were given oral tegafur-uracil (UFT s , 400 -600 mg day À1 ). The AUC group showed a significantly lower percentage platelet reduction than the BS group (49.0722.0 vs 65.1723.2%; P ¼ 0.045) and also tended to have a higher platelet nadir count (10.974.2 vs 8.475.8 Â 10 4 ; P ¼ 0.27) without reducing the antitumour effect. The value of 4.5 for target AUC is recommended clinically. However, AUC of Calvert's formula could not predict thrombocytopenia associated with intraarterial chemoradiotherapy due to the variability of the actual AUC.

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Superselective cisplatin (CDDP)-carboplatin (CBDCA) combined infusion for head and neck cancers

Cited by 40 publications

References 19 publications

A Cone-Beam Volume CT Using a 3D Angiography System with a Flat Panel Detector of Direct Conversion Type: Usefulness for Superselective Intra-arterial Chemotherapy for Head and Neck Tumors

A Cone-Beam Volume CT Using a 3D Angiography System with a Flat Panel Detector of Direct Conversion Type: Usefulness for Superselective Intra-arterial Chemotherapy for Head and Neck Tumors

Intra-arterial chemoradiotherapy for head and neck cancer

AUC of Calvert's formula in targeted intra-arterial carboplatin chemoradiotherapy for cancer of the oral cavity

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