Supersaturation maintenance of carvedilol and chlorthalidone by cyclodextrin derivatives: Pronounced crystallization inhibition ability of methylated cyclodextrin

Supersaturated Drug Delivery System of Oxyberberine Based on Cyclodextrin Nanoaggregates: Preparation, Characterization, and in vivo Application

“…This result was overall consistent with the preceding result that the supersaturated solution of OBB was not completely stable. Meanwhile, previous report has suggested that the maintenance of drug supersaturation by CDs was less related to the inclusion complex formation between CDs and drugs, 35 which also indicated that OBB-HP-β-CD SDDS was different from traditional drug-cyclodextrin inclusion complex. Despite this, OBB-HP-β-CD SDDS did display an extremely excellent solubilization effect of OBB.…”

“…However, upon standing for a period, slow precipitation could be observed, which indicated that OBB supersaturation solutions were formed, and this outcome was inconsistent with traditional drug-CD inclusion complexes. 35 Therefore, the sample was considered to have formed a supersaturated system after dissolution.…”

Inhibition of Crystal Nucleation and Growth: A Review

“…Budiman et al ’s study on maintaining alpha-mangostin (AM) , found that hydrocarbyl groups of water-soluble chitosan molecules and methyl groups of PVP molecules could form hydrogen bonds with the carbonyl group of AM through Fourier transform infrared (FT-IR), NMR, and computer studies, thereby inhibiting the molecular mobility of alpha-mangostin and inhibiting the formation of crystal nuclei. Liu et al found that the hydrophobic interaction between cyclodextrin and two drugs with low water solubility, namely carvedilol and chlorthalidone, could effectively inhibit the crystallization of the two drug molecules, and the ability of cyclodextrin to inhibit crystallization was closely related to its hydrophobicity. Taylor et al found that the bacterial amyloid inhibitor CsgC can guide molecular encounters through electrostatic action, strongly inhibit initial nucleation, and delay the formation of high-grade amyloid intermediates.…”