Superposition extreme high-altitude exposure (8848m) forms episodic memory of LIPN and PLCH1 genes associated

Abstract

Background: Extreme environmental stress interactions with DNA methylation may produce episodic memory for environmental adaptation. Methods: In the present study, 64 volunteers born and living at an altitude of 4,700 m were recruited, including 32 volunteers who were repeatedly exposed to high altitudes (up to 8,848 m, up to 11 times). We explored the changes in the genes hosting 741,489 CpG loci as well as 39 physiological phenotypes under superposition extreme high-altitude exposure (SEH). Results: 13 CpG for 11 genes were identified with tightly linked networks to five phenotypes. Bayesian causal network analysis suggests network properties of 15 SEH-related phenotypic networks and MP-SSN, reflected in increased robustness with an increasing number of SEH exposures, suggesting environmental resistance. In addition, we explored the characteristics under SEH of the MP-SSN network nodes in populations with significant differences in SpO2 (n High-adaptability= 28; n Low-adaptability= 36) and found concomitant changes in five phenotypes and CpG methylation, while the changes occurred earlier in the high SpO2 population (Climbing age = 5 times). Conclusion: Considering evidence from the literature and database validation, we suggest that the promoter and enhancer regions of the LIPN and PLCH1 genes may be influenced by methylation memory generated by light environment exposure during SEH exposure. Methylation memory may have an effect on the phenotype by influencing the action of the pathway in which the gene is located, thus advancing the environmental adaptation status of SEH, such as SpO2 and SP.