Superparamagnetic plasmonic nanoshells for improved imaging, separation and seeding of co-cultured cells

Jin, Xiulong; Yu, Hongfei; Kong, Ni; Chang, Jiang; Li, Haiyan; Ye, Jian

doi:10.1039/c5tb01420d

Cited by 4 publications

(3 citation statements)

References 57 publications

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“…Therefore, according to the above cell viability study, RNMs with a concentration from 0 to 6.5 × 10 10 mL –1 can be considered to be noncytotoxic. The bright-field (BF) images of HeLa cells incubated with silica-coated (i) NBT-, (ii) NT-, and (iii) BDT-RNMs indicate that all SERS probes are nonspecifically swallowed and accumulated around the cell nucleus, which is similar to the previous observation . The overlaid images show that the SERS images fit well with the corresponding BF images for all three types of off-resonant RNMs.…”

Section: Resultssupporting

confidence: 82%

“…The bright-field (BF) images of HeLa cells incubated with silicacoated (i) NBT-, (ii) NT-, and (iii) BDT-RNMs indicate that all SERS probes are nonspecifically swallowed and accumulated around the cell nucleus, which is similar to the previous observation. 68 The overlaid images show that the SERS images fit well with the corresponding BF images for all three types of off-resonant RNMs. The possibility of multiplexed SERS imaging using the mixture of three RNMs is demonstrated in Figure 4d.…”

Section: Resultsmentioning

confidence: 65%

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Rational Design of Ultrabright SERS Probes with Embedded Reporters for Bioimaging and Photothermal Therapy

Jin¹,

Khlebtsov

Khanadeev

et al. 2017

ACS Appl. Mater. Interfaces

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Plasmonic nanoparticles can be utilized as surface-enhanced Raman scattering (SERS) probes for bioimaging and as photothermal (PT) agents for cancer therapy. Typically, their SERS and PT efficiencies reach maximal values under the on-resonant condition, when the excitation wavelength overlaps the localized surface plasmon resonance (LSPR) wavelength preferably in the near-infrared (NIR) biological window. However, the photogenerated heat may inevitably disturb or even destroy biological samples during the imaging process. Herein, we develop ultrabright SERS probes composed of metallic Au@Ag core-shell rodlike nanomatryoshkas (RNMs) with embedded Raman reporters. By rationally controlling the Ag shell thickness, the LSPR of RNMs can be tuned from UV to NIR range, resulting in highly tunable SERS and PT properties. As bright NIR SERS imaging nanoprobes, RNMs with a thick Ag shell are designed for minimal PT damage to the biological targets under the off-resonance condition, as illustrated through monitoring the changes in mitochondrial membrane potential of cancer cells during SERS imaging procedure. By contrast, RNMs with a thin Ag shell are designed as multifunctional NIR theranostic probes that combine enhanced photothermal therapy capability, as exemplified by efficient PT killing of cancer cells, with reduced yet still efficient imaging properties at the on-resonance excitation.

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Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 65%

Rational Design of Ultrabright SERS Probes with Embedded Reporters for Bioimaging and Photothermal Therapy

Jin¹,

Khlebtsov

Khanadeev

et al. 2017

ACS Appl. Mater. Interfaces

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“…16 Briefly, PBSu particles (Shanghai Showa Highpolymer Co. Ltd) were dissolved in selected volumes of dimethyl formamide (Shanghai Lingfeng Chemical Reagent Co. Ltd) to prepare a polymer solution. Selected amounts of m-MS were added to PBSu solution with continuous stirring to obtain a uniform dispersion.…”

Section: Preparation and Characterization Of M-ms/pbsu Composite Scafmentioning

confidence: 99%

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Zheng

Zhang

et al. 2016

J. Mater. Chem. B

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Bioactive scaffolds of magnesium silicate (m-MS)/poly(butylene succinate) (PBSu) composites were fabricated by a solvent casting-particulate leaching method for bone regeneration. The scaffolds had a hierarchical porous structure with interconnected macropores (300-500 mm), micropores (1-10 mm) and mesopores (B5 nm). In addition, the composite scaffolds were degradable in Tris-HCl solution and The results demonstrated that the bioactive m-MS/PBSu composite scaffolds with good biocompatibility, degradability, bioactivity and osteogenesis are promising biomaterials for bone repair.

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Magneto-Plasmonic Nanoparticles

Fernández

Pineider

2021

New Trends in Nanoparticle Magnetism

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Superparamagnetic plasmonic nanoshells for improved imaging, separation and seeding of co-cultured cells

Abstract: Multifunctional superparamagnetic nanoshells were applied for improved 2D and 3D two-photon luminescence imaging, separation and seeding of co-cultured cells.

Cited by 4 publications

References 57 publications

Rational Design of Ultrabright SERS Probes with Embedded Reporters for Bioimaging and Photothermal Therapy

Rational Design of Ultrabright SERS Probes with Embedded Reporters for Bioimaging and Photothermal Therapy

Effects of magnesium silicate on the mechanical properties, biocompatibility, bioactivity, degradability, and osteogenesis of poly(butylene succinate)-based composite scaffolds for bone repair

Magneto-Plasmonic Nanoparticles

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