Superparamagnetic nanoarchitectures for disease-specific biomarker detection

Masud, Mostafa Kamal; Na, Jongbeom; Younus, Muhammad; Hossain, Md. Shahriar A.; Bando, Yoshio; Shiddiky, Muhammad J. A.; Yamauchi, Yusuke

doi:10.1039/c9cs00174c

Cited by 207 publications

(165 citation statements)

References 342 publications

(281 reference statements)

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“…[1] Introduction of nanostructured materials had a phenomenal impact on the biosensing field as they brought unparalleled diversity and improved analytical performances (i. e., better sensitivity, specificity, board dynamic range, reproducibility, stability, etc.). [2][3][4] Simple nanostructured materials (e. g., metal nanoparticles) that exhibit enzyme-mimicking catalytic activity are referred to as nanozymes. These inorganic catalysts can easily convert a colorless enzyme substrate [e. g., 3,3,5,5-tetramethylbenzidine (TMB), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), 3,3'-diaminobenzidine (DAB), and o-phenylenediamine dihydrochloride (OPD)] to a colored product while following the principles of natural enzyme (i. e., peroxidase) kinetics.…”

Section: Introductionmentioning

confidence: 99%

“…Introduction of nanostructured materials had a phenomenal impact on the biosensing field as they brought unparalleled diversity and improved analytical performances (i. e., better sensitivity, specificity, board dynamic range, reproducibility, stability, etc.) . Simple nanostructured materials (e. g., metal nanoparticles) that exhibit enzyme‐mimicking catalytic activity are referred to as nanozymes.…”

Section: Introductionmentioning

confidence: 99%

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Vanadium‐Substituted Tungstosulfate Polyoxometalates as Peroxidase Mimetics and Their Potential Application in Biosensing

et al. 2020

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This article reports on the peroxidase-like catalytic activity of polyoxometalates (POMs) and their potential use as natural peroxidases for developing a simple and efficient colorimetric glucose sensor. Two Keggin-type vanadium-substituted tungstosulfates, [SVW 11 O 40 ] 3À (SVW 11) and [SV 2 W 10 O 40 ] 4À (SV 2 W 10), were tested for their potential as natural enzyme mimetics and exhibited strong peroxidase-like catalytic activity. The catalysis reaction was found to be in accordance with Michaelis-Menten and Lineweaver-Burk kinetics models. Michaelis-Menten constant (K m) and maximum velocity (V max) parameters were calculated to be 0.0759 mM and 0.329 × 10 À 8 Ms À 1 for SVW 11 , and 0.0543 mM and 2.67 × 10 À 8 Ms À 1 for SV 2 W 10 , respectively, indicating a high catalytic activity and a strong affinity of POMs towards 3,3,5,5-tetramethylbenzidine (TMB). In the case of H 2 O 2 , these values were found to be 57.1 mM and 0.325 × 10 À 8 mMs À 1 for SVW 11 , and 47.7 mM and 2.72 × 10 À 8 mMs À 1 for SV 2 W 10. The peroxidase-like catalytic activity of these POMs was used to develop colorimetric glucose sensors as a proof-of-concept model for the POM-based naked-eye detection of biomolecules. The limit of detcetion (LOD) of glucose for SVW 11 and SV 2 W 10 was 1.14 μM and 1.24 μM, respectively. Our findings propose broad-ranging potential applications of these novel POMs in biosensing and bioanalytical chemistry.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vanadium‐Substituted Tungstosulfate Polyoxometalates as Peroxidase Mimetics and Their Potential Application in Biosensing

et al. 2020

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“…This would be highly useful in the future to develop a technique for efficient imaging of bioanalytes such as red blood cells, white blood cells and platelet. Fabrication of gradient films can also be carried out by using magnetic colloids conjugated or functionalized with specific biomarkers such as nucleic acids (DNA and RNA), proteins, autoantibodies and cells, which further enhance the cellular visualization [60]. MRI data of thin films magnetically engineered thin film gradients can also be reported for cancerous and healthy cells.…”

Section: Mri Studies Of Thin Film Gradientsmentioning

confidence: 99%

pH Tunable Thin Film Gradients of Magnetic Polymer Colloids for MRI Diagnostics

Khizar

Ahmad

2020

Polymers

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Magnetic polymer colloids comprising of magnetite (Fe3O4) nanoparticles and Eudragit E100 were employed to fabricate thin film gradients and were investigated for in-vitro magnetic resonance imaging. Magnetic polymer colloids (MPC) and polyacrylic acid (PAA) with stimuli-responsive cationic and anionic functional groups respectively facilitate the formation of thin film gradients via layer by layer technique. The characteristics of films were controlled by changing the pH and level of the adsorbing solutions that lead to the development of gradient films having 5.5, 10.5 and 15.5 bilayers. Optical microscopy, scanning electron microscopy and magnetic force microscopy was carried out to determine the surface coverage of films. Surface wettability demonstrated the hydrophilicity of adsorbed colloids. The developed thin-film gradients were explored for in vitro magnetic resonance imaging that offers a point of care lab-on-chip as a dip-stick approach for ultrasensitive in-vitro molecular diagnosis of biological fluids.

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“…Previous literature reports include micro/nanomaterial-based systems for multiomics technologies and precision oncology [ 1 ], an overview of the existing liquid biopsy technologies in general [ 2 ], nanoarchitecture frameworks for electrochemical miRNA detection [ 4 ], nanotechnology-based liquid biopsy applications for ctDNA and exosomes detection [ 10 ], nucleic acids sensors for liquid biopsy applications [ 25 ] and plasmonic and supermagnetic nanomaterials for liquid biopsy applications [ 24 , 35 ]. The present review reports on all the nanomaterials used in emerging liquid biopsy applications, targeting all the relevant biomarkers; furthermore, the analytical performance of the nanomaterials is also evaluated.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology in emerging liquid biopsy applications

Kalogianni

2021

Nano Convergence

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Liquid biopsy is considered as the most attractive alternative to traditional tissue biopsies. The major advantages of this approach lie in the non-invasive procedure, the rapidness of sample collection and the potential for early cancer diagnosis and real-time monitoring of the disease and the treatment response. Nanotechnology has dynamically emerged in a wide range of applications in the field of liquid biopsy. The benefits of using nanomaterials for biosensing include high sensitivity and detectability, simplicity in many cases, rapid analysis, the low cost of the analysis and the potential for portability and personalized medicine. The present paper reports on the nanomaterial-based methods and biosensors that have been developed for liquid biopsy applications. Most of the nanomaterials used exhibit great analytical performance; moreover, extremely low limits of detection have been achieved for all studied targets. This review will provide scientists with a comprehensive overview of all the nanomaterials and techniques that have been developed for liquid biopsy applications. A comparison of the developed methods in terms of detectability, dynamic range, time-length of the analysis and multiplicity, is also provided.

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Superparamagnetic nanoarchitectures for disease-specific biomarker detection

Abstract: Synthesis, bio-functionalization, and multifunctional activities of superparamagnetic-nanostructures have been extensively reviewed with a particular emphasis on their uses in a range of disease-specific biomarker detection and associated challenges.

Cited by 207 publications

References 342 publications

Vanadium‐Substituted Tungstosulfate Polyoxometalates as Peroxidase Mimetics and Their Potential Application in Biosensing

Vanadium‐Substituted Tungstosulfate Polyoxometalates as Peroxidase Mimetics and Their Potential Application in Biosensing

pH Tunable Thin Film Gradients of Magnetic Polymer Colloids for MRI Diagnostics

Nanotechnology in emerging liquid biopsy applications

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