Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment
Natalie K. Horvat,
Sara Chocarro,
Oriana Marques
et al.
Abstract:ALK-positive NSCLC patients demonstrate initial responses
to ALK
tyrosine kinase inhibitor (TKI) treatments, but eventually develop
resistance, causing rapid tumor relapse and poor survival rates. Growing
evidence suggests that the combination of drug and immune therapies
greatly improves patient survival; however, due to the low immunogenicity
of the tumors, ALK-positive patients do not respond to currently available
immunotherapies. Tumor-associated macrophages (TAMs) play a crucial
role in facilitating lung… Show more
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