Superparamagnetic iron oxide nanoparticles coated with a folate-conjugated polymer

Zhang, Quan; Wang, Chenhong; Qiao, Lei; Yan, Husheng; Liu, Keliang

doi:10.1039/b910439a

Cited by 45 publications

(31 citation statements)

References 46 publications

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“…The percentage weight loss of bare MSNPs was about 5.3% over the whole temperature range, which was largely due to the removal of absorbed water and the dehydroxylation of silanol groups. For PEG‐MSNPs, the percentage weight loss was significant, because low molecular weight PEG chains were degraded at ≈280 °C . Moreover, greater weight losses of PEG‐MSNPs‐SS‐COOH, PEG‐MSNPs‐SS‐CD and PEG‐MSNPs‐CD‐PEG‐FA were attributed to the degradation of β ‐CD(NH 2 ) 7 and FA‐PEG‐Ad, indicating that β ‐CD(NH 2 ) 7 and FA‐PEG‐Ad were successfully immobilized onto the surface of the nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

Biocompatible, Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer‐Targeted Drug Delivery In Vivo

Zhang

Wang

et al. 2013

Adv Funct Materials

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250

169

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Engineering multifunctional nanocarriers for targeted drug delivery shows promising potentials to revolutionize the cancer chemotherapy. Simple methods to optimize physicochemical characteristics and surface composition of the drug nanocarriers need to be developed in order to tackle major challenges for smooth translation of suitable nanocarriers to clinical applications. Here, rational development and utilization of multifunctional mesoporous silica nanoparticles (MSNPs) for targeting MDA‐MB‐231 xenograft model breast cancer in vivo are reported. Uniform and redispersible poly(ethylene glycol)‐incorporated MSNPs with three different sizes (48, 72, 100 nm) are synthesized. They are then functionalized with amino‐β‐cyclodextrin bridged by cleavable disulfide bonds, where amino‐β‐cyclodextrin blocks drugs inside the mesopores. The incorporation of active folate targeting ligand onto 48 nm of multifunctional MSNPs (PEG‐MSNPs48‐CD‐PEG‐FA) leads to improved and selective uptake of the nanoparticles into tumor. Targeted drug delivery capability of PEG‐MSNPs48‐CD‐PEG‐FA is demonstrated by significant inhibition of the tumor growth in mice treated with doxorubicin‐loaded nanoparticles, where doxorubicin is released triggered by intracellular acidic pH and glutathione. Doxorubicin‐loaded PEG‐MSNPs48‐CD‐PEG‐FA exhibits better in vivo therapeutic efficacy as compared with free doxorubicin and non‐targeted nanoparticles. Current study presents successful utilization of multifunctional MSNP‐based drug nanocarriers for targeted cancer therapy in vivo.

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Section: Resultsmentioning

confidence: 99%

Biocompatible, Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer‐Targeted Drug Delivery In Vivo

Zhang

Wang

et al. 2013

Adv Funct Materials

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250

169

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“…Recent reports have shown that uptaking of anticancer compounds by tumor cells could be improved after the loading of these agents on the surface of Fe 3 O 4 MNPs and applying a magnetic field . Furthermore, in some cases, the combination of the various agents with Fe 3 O 4 MNPs could improve the therapeutic effect and stability of the produced nanostructures .…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of the effect of Fe₃O₄@piroctone olamine magnetic nanoparticles on matrix metalloproteinase‐2: A preliminary in vitro study

Shakibaie

Haghiri

Jafari

et al. 2014

Biotech and App Biochem

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In the present study, Fe3 O4 magnetic nanoparticles were synthesized by the coprecipitation of Fe(2+) and Fe(3+) ions and used as a nanocarrier for the production of piroctone-olamine-loaded Fe3 O4 nanoparticles (Fe3 O4 @PO NPs). The nanocrystalline structure of the prepared iron oxide species was confirmed by the X-ray diffraction spectroscopy method. Particle size distribution analysis showed that the size of Fe3 O4 @PO NPs was in the range of 5-55 nm. The magnetization curve of Fe3 O4 @PO NPs (with saturation magnetization of 28.2 emu/g) confirmed its ferromagnetic property. Loading of PO on the surface of Fe3 O4 NPs qualitatively verified by Fourier transform infrared spectrum obtained from Fe3 O4 @PO NPs. Cytotoxicity studies on the human fibrosarcoma cell line (HT-1080) revealed higher inhibitory effect of Fe3 O4 @PO NPs (50% cell death [IC50 ] of 8.1 µg/mL) as compared with Fe3 O4 NPs (IC50 of 117.1 µg/mL) and PO (IC50 of 71.2 µg/mL) alone. In the case of human normal fibroblast (Hs68), the viability percentage was found to be 75% in the presence of Fe3 O4 @PO NPs (120 µg/mL). Gelatin zymography showed 17.2% and 34.6% inhibition of matrix metalloproteinase-2 (MMP-2) in the presence of Fe3 O4 @PO and PO, respectively, at the same concentration of 40 µg/mL, whereas Fe3 O4 NPs did not inhibit MMP-2 at any concentration.

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“…Fmoc-PMPC was obtained by ATRP (Atom Transfer Radical Polymerization) of 2-methacryloyloxyethylphosphorylcholine (MPC) using Fmoc-protected bromoisobutylate derivative (Fmoc-initiator) 41 as an initiator under manipulated control of the initiator/monomer ratios. Thus, in a typical preparation, CuBr (2.9 mg, 0.020 mmol) and 2,2′-bipyridine (6.16 mg, 0.039 mmol) as catalysts were added to a solution of MPC (511.6 mg, 1.73 mmol) and Fmoc-protected initiator (5.8 mg, 0.010 mmol) in degassed methanol (1.0 mL) in a nitrogen glove box.…”

Section: Methodsmentioning

confidence: 99%

Photoacoustic in vivo 3D imaging of tumor using a highly tumor-targeting probe under high-threshold conditions

Yamada

Matsumoto

Komaki

et al. 2020

Sci Rep

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Three-dimensional (3D) representation of a tumor with respect to its size, shape, location, and boundaries is still a challenge in photoacoustic (PA) imaging using artificial contrast agents as probes. We carried out PA imaging of tumors in mice using 800RS-PMPC, which was obtained by coupling of 800RS, a near-infrared cyanine dye, with PMPC, a highly selective tumor-targeting methacrylate polymer having phosphorylcholine side chains, as a probe. The conjugate 800RS-PMPC forms compact nanoparticles (dDLS = 14.3 nm), retains the biocompatibility of the parent polymer (PMPC) and exhibits unprecedented PA performance. When applied to mice bearing a 6 × 3 × 3 mm3 tumor buried 6 mm beneath the skin, the probe 800RS-PMPC selectively accumulates in the tumor and emits PA signals that are strong enough to be unambiguously distinguished from noise signals of endogenous blood/hemoglobin. The PA image thus obtained under high-threshold conditions allows 3D characterization of the tumor in terms of its size, shape, location, and boundaries.

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Superparamagnetic iron oxide nanoparticles coated with a folate-conjugated polymer

Cited by 45 publications

References 46 publications

Biocompatible, Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer‐Targeted Drug Delivery In Vivo

Biocompatible, Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer‐Targeted Drug Delivery In Vivo

Preparation and evaluation of the effect of Fe₃O₄@piroctone olamine magnetic nanoparticles on matrix metalloproteinase‐2: A preliminary in vitro study

Photoacoustic in vivo 3D imaging of tumor using a highly tumor-targeting probe under high-threshold conditions

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Superparamagnetic iron oxide nanoparticles coated with a folate-conjugated polymer

Cited by 45 publications

References 46 publications

Biocompatible, Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer‐Targeted Drug Delivery In Vivo

Biocompatible, Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer‐Targeted Drug Delivery In Vivo

Preparation and evaluation of the effect of Fe3O4@piroctone olamine magnetic nanoparticles on matrix metalloproteinase‐2: A preliminary in vitro study

Photoacoustic in vivo 3D imaging of tumor using a highly tumor-targeting probe under high-threshold conditions

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Preparation and evaluation of the effect of Fe₃O₄@piroctone olamine magnetic nanoparticles on matrix metalloproteinase‐2: A preliminary in vitro study