Superparamagnetic Iron Oxide for Identifying Sentinel Lymph Node in Breast Cancer after Neoadjuvant Chemotherapy: Feasibility Study

Kurylcio, Andrzej; Pelc, Zuzanna; Skórzewska, Magdalena; Rawicz‐Pruszyński, Karol; Mlak, Radosław; Gęca, Katarzyna; Sędłak, Katarzyna; Kurylcio, Piotr; Małecka‐Massalska, Teresa; Polkowski, Wojciech

doi:10.3390/jcm10143149

Cited by 8 publications

(8 citation statements)

References 53 publications

(69 reference statements)

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“…Since AMAROS' trial results, the gold standard for SLNB in BC patients remains the RI technique, which presents a comparable detection rate to the dual technique [12,19,31]. Numerous studies confirmed the noninferiority of SPIO to RI in the upfront surgery setting [16,17,24,25,32]. Since 2014, when Rubio et al presented promising data on the outcome of SLNB after NAC using a dual tracer (SPIO-TC99) at the ASCO annual meeting [33], the results of the SENTINAC-01 clinical trial are awaited [34].…”

Section: Discussionmentioning

confidence: 99%

“…After neoadjuvant treatment, BC patients are randomized into three groups, with SLNB guided by dual tech-nique, combined RI + SPIO or SPIO alone. Our previous study established SPIO-guided SLNB after NAC as a safe and feasible method [17].…”

Section: Discussionmentioning

confidence: 99%

“…Sienna+ ® (Sysmex Europe GmBH, Hamburg, Germany) and Magtrace ® (Endomagnetics Limited, Cambridge, UK) were used. SPIO was injected deeply into the subareolar interstitial tissue, followed by SentiMag ® probe measurements as previously described [17].…”

Section: Sentinel Lymph Node Biopsymentioning

confidence: 99%

“…However, Corso et al suggest a significant discrepancy between the FNR and detection rate depends on the individual experience of the research center or incoherent structure of retrospective studies [15]. Numerous trials and meta-analyses revealed the noninferiority of the SPIO to the gold standard isotope technique [16][17][18][19][20][21][22][23][24][25][26][27]. However, these studies did not include BC patients after NAC.…”

Section: Introductionmentioning

confidence: 99%

“…However, these studies did not include BC patients after NAC. Recently, we have determined that SPIO is a feasible and oncologically safe method for identifying SN in BC patients after preoperative treatment [17]. Therefore, the present study aimed to compare the identification rate (IR) of SPIO-guided SLNB to RI in BC patients after receiving neoadjuvant treatment based on the Propensity Score Matching (PSM) analysis.…”

Section: Introductionmentioning

confidence: 99%

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A Propensity Score Matched Analysis of Superparamagnetic Iron Oxide versus Radioisotope Sentinel Node Biopsy in Breast Cancer Patients after Neoadjuvant Chemotherapy

Pelc

Skórzewska

Kurylcio

et al. 2022

Cancers

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The standard method for nodal staging in breast cancer (BC) patients after neoadjuvant chemotherapy (NAC) is sentinel lymph node biopsy (SLNB) with a radioisotope (RI) injection. However, SLNB after NAC results in high false-negative rates (FNR), and the RI method is restricted by nuclear medicine unit dependency. These limitations resulted in the development of the superparamagnetic iron oxide (SPIO) method, reducing FNR and presenting a comparable detection rate. This bi-institutional cohort comparison study aimed to assess the efficacy of SPIO and radioisotope SNLB in BC patients after NAC using Propensity Score Matching (PSM) analysis. The study group comprised 508 patients who underwent SLNB after NAC for ycT1-4N0M0 BC between 2013 and 2021 in two high volume centers. Data were retrieved from prospectively conducted databases. In the SPIO group, the median of retrieved sentinel lymph nodes (SLNs) was significantly higher than in the RI group (3 vs. 2; p < 0.0001). The SPIO method was associated with a significantly higher chance of retrieving at least three lymph nodes when compared to the RI method (71% vs. 11.3%; p < 0.0001). None of the analyzed demographic and clinical variables had a statistically significant influence on the efficacy of SLNs retrieval in the RI group, while in the SPIO group, patients with ≥ three harvested SLNs had lower weight and decreased BMI. Based on this PSM analysis, SPIO-guided SLNB allowed the efficient retrieval and detection of SLNs in BC patients after NAC compared to RI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Sentinel Lymph Node Biopsymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Propensity Score Matched Analysis of Superparamagnetic Iron Oxide versus Radioisotope Sentinel Node Biopsy in Breast Cancer Patients after Neoadjuvant Chemotherapy

Pelc

Skórzewska

Kurylcio

et al. 2022

Cancers

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Safety and Efficacy of Mitoxantrone Hydrochloride Injection for Identification of Axillary Sentinel Lymph Nodes in Patients with Primary Breast Cancer

2023

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Background The dual technique using blue dye in combination with a radioisotope is considered the gold standard for identifying sentinel lymph nodes (SLNs) in patients with breast cancer. Unfortunately, not all cancer centres have access to radioactive material, which jeopardizes the SLN identification rate and patient safety. Aim We aimed to assess the safety and efficacy of mitoxantrone hydrochloride injection (MHI) for identifying axillary SLNs in patients with primary breast cancer. Patients and methodsWe have conducted a prospective non-randomized analysis of patients diagnosed with invasive breast cancer who agreed to participate in the study between December 2019 and December 2022. We have used the patient's medical records to collect the data. We have used the SLN intraoperative identification rate as a marker for the efficacy of the technique and both the immediate and delayed complication rates and routine blood tests as markers for the safety of the technique. Results Out of the 296 patients, 289 (97.6%) had their SLNs identified using MHI, while seven patients (2.3%) had four-node sampling carried out because the SLNs were not identified. Liver functions were not significantly affected by MHI, and there was no technique-related readmission or reported morbidity or mortality. Conclusion We have found that the MHI technique is still inferior to the combined radioactive directed technique and patent blue V dye in SLN identification. Yet, it may serve as a safe and reliable alternative in cases where the radioactive technique is unavailable.

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The Introduction of Magtrace® Lymphatic Tracer for Axillary Sentinel Node Biopsy for Breast Cancer in a Rural Scottish District General Hospital: Initial Experience, Perspectives, Outcomes and Learning Curves

Kong,

Williams,

Hemadasa

et al. 2024

Clinical Breast Cancer

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Superparamagnetic Iron Oxide for Identifying Sentinel Lymph Node in Breast Cancer after Neoadjuvant Chemotherapy: Feasibility Study

Cited by 8 publications

References 53 publications

A Propensity Score Matched Analysis of Superparamagnetic Iron Oxide versus Radioisotope Sentinel Node Biopsy in Breast Cancer Patients after Neoadjuvant Chemotherapy

A Propensity Score Matched Analysis of Superparamagnetic Iron Oxide versus Radioisotope Sentinel Node Biopsy in Breast Cancer Patients after Neoadjuvant Chemotherapy

Safety and Efficacy of Mitoxantrone Hydrochloride Injection for Identification of Axillary Sentinel Lymph Nodes in Patients with Primary Breast Cancer

The Introduction of Magtrace® Lymphatic Tracer for Axillary Sentinel Node Biopsy for Breast Cancer in a Rural Scottish District General Hospital: Initial Experience, Perspectives, Outcomes and Learning Curves

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